Cortisol and susceptibility to malaria during pregnancy

Bouyou-Akotet, Marielle Karine; Adegnika, Ayôla Akim; Agnandji, Selidji Todagbé; Ngou-Milama, Édouard; Kombila, Maryvonne; Kremsner, Peter G.; Mavoungou, Elie

doi:10.1016/j.micinf.2005.04.008

Cited by 49 publications

(42 citation statements)

References 47 publications

(57 reference statements)

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“…In the study, there was high prevalence of malaria parasitemia amongst the examined set (Table, 1) which was in line with several studies including; (Lindsay et al, 2000;Martνnez-Espinosa et al, 2000;Bouyou-Akotet et al, 2005;Rogerson and Boeu 2007;Chimere et al, 2009;Enato et al, 2009;WHO, 2010;Olunfemi et al, 2012) where results indicated heavy and multiple species malaria parasitemia in pregnancy. Naturally, indigenes of the study area readily acquire immunity due to repeated exposure to Plasmodium spp.…”

Section: Suppressed Immunity Due To Pregnancysupporting

confidence: 89%

“…Care Centre Aluu, Port Harcourt, Rivers State, Nigeria Espinosa et al, 2000;Bouyou-Akotet et al, 2005;Rogerson and Boeu, 2007and Enato et al, 2007WHO, 2010). In endemic countries like Nigeria, 20% of malaria parasitemia in pregnancy are asymptomatic, with susceptibility to parasitemia common in primgravidae (Desai et al, 2007;, Amoran, 2012.…”

Section: Nzeako Et Al Prevalence Of Malaria In Pregnant Women Attendmentioning

confidence: 99%

“…(Amoran, 2012;Molina and Gonzalez, 2012). This decline in immunity could be attributed to physiological and behavioural changes that result to increase in the levels of cortisol and volatile compounds that make pregnant women more attractive to infected female anopheles mosquito (Lindsay et al, 2000;Martνnez-Espinosa et al, 2000;Bouyou-Akotet et al, 2005;Boeu 2007 andEnato et al, 2009;WHO, 2010;Molina and Gonzalez, 2012). Another factor that may have impacted on the disparity in malaria parasitemia is the patronage of alternative ante natal health care providers such as herbalists, and traditional midwifes scattered around the rural areas of Nigeria by pregnant women.…”

Section: Suppressed Immunity Due To Pregnancymentioning

confidence: 99%

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Prevalence of Malaria in Pregnant Women Attending Ante Natal Care at University of Port Harcourt Primary Health Care Centre Aluu, Port Harcourt, Rivers State, Nigeria

Nzeako¹,

Nduka²,

Origie³

2013

IJSRES

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Abstract. Venule blood samples were randomly collected from eighty pregnant women receiving ante natal care in the University of Port Harcourt Primary Health Care Centre after obtaining ethical clearance. These blood samples were put in EDTA properly designated bottles and taken to the Parasitology Laboratory, Department of Animal and Environmental Biology for examination. The standard thick and thin smears were used to examine the blood specimens. Overall prevalence showed that 72.5% of the pregnant women were infected with malaria. Specific Plasmodium prevalence amongst the infected showed that 63.5% were infected with P. falciparum; 18.9% for P. vivax; 15.5% for P.malariae and 1.7% for P.ovale. There was no statistically significant (P>0.05) increase in the prevalence of Plasmodium species between the primigravidea (58.6%) and the multigravidae (41.3%). The disparity in parasitemia was attributed to pregnancy induced delayed antibody expression in the primigravidae. The study emphasized the significance of health education in malaria control especially during pregnancy.

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Section: Suppressed Immunity Due To Pregnancysupporting

confidence: 89%

Section: Nzeako Et Al Prevalence Of Malaria In Pregnant Women Attendmentioning

confidence: 99%

Section: Suppressed Immunity Due To Pregnancymentioning

confidence: 99%

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Prevalence of Malaria in Pregnant Women Attending Ante Natal Care at University of Port Harcourt Primary Health Care Centre Aluu, Port Harcourt, Rivers State, Nigeria

Nzeako¹,

Nduka²,

Origie³

2013

IJSRES

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“…We found that cortisol concentrations were higher in primigravidae than in multigravidae, and also higher in P. falciparum-infected primigravidae than in uninfected primigravidae throughout pregnancy and at the time of delivery. 88 We showed that prolactin concentration did not differ according to P. falciparum status. The low NK cell cytotoxic activity we found was correlated with high cortisol concentrations.…”

Section: Cortisol Prolactin and Susceptibility Of Pregnant Women To mentioning

confidence: 67%

Interactions Between Natural Killer Cells, Cortisol and Prolactin in Malaria During Pregnancy

Mavoungou¹

2006

Clinical Medicine & Research

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Natural killer cells derived from pluripotent hematopoietic stem cells are important cells of the immune system that have two main functions: a cytolytic activity and a cytokine-producing capacity. These functions are tightly regulated by numerous activating and inhibitory receptors, including newly discovered receptors that selectively trigger the cytolytic activity in a major histocompatibility complex independent manner. Based on their defining function of spontaneous cytotoxicity without prior immunization, natural killer (NK) cells have been thought to play a critical role in immune surveillance and cancer therapy. New insights into NK cell biology have suggested their major roles in the control of infections, particularly in Plasmodium falciparum infection and in fetal implantation. P. falciparum is the main protozoan parasite responsible for malaria causing 200-300 million clinical cases and killing over 3 million people each year. This review provides an update on NK cell function, ontogeny and biology in order to better understand the role of NK cells in pregnancy in regions where malaria is endemic. Understanding mechanisms of NK cell functions may lead to novel therapeutic strategies for the treatment of human disease, in general, and particularly in the fight against malaria.

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“…Levels of corticosteroids, which suppress cell-mediated immunity, are substantially increased during the third trimester of pregnancy, in primiparous women, and in P. falciparum-infected pregnant women compared with other pregnant women (311). Cortisol concentrations have been found to be significantly higher in primigravidae than in multigravidae; conversely, plasma prolactin levels have been highest in multigravidae (37). Placental P. falciparum infection is also likely to have an effect on the development of immunity in the offspring due to in utero sensitization to parasite antigens (reviewed in references 45 and 107), and this research area has recently gained increasing interest.…”

Section: Characteristics Of Naimentioning

confidence: 99%

Acquired Immunity to Malaria

2009

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SUMMARY Naturally acquired immunity to falciparum malaria protects millions of people routinely exposed to Plasmodium falciparum infection from severe disease and death. There is no clear concept about how this protection works. There is no general agreement about the rate of onset of acquired immunity or what constitutes the key determinants of protection; much less is there a consensus regarding the mechanism(s) of protection. This review summarizes what is understood about naturally acquired and experimentally induced immunity against malaria with the help of evolving insights provided by biotechnology and places these insights in the context of historical, clinical, and epidemiological observations. We advocate that naturally acquired immunity should be appreciated as being virtually 100% effective against severe disease and death among heavily exposed adults. Even the immunity that occurs in exposed infants may exceed 90% effectiveness. The induction of an adult-like immune status among high-risk infants in sub-Saharan Africa would greatly diminish disease and death caused by P. falciparum. The mechanism of naturally acquired immunity that occurs among adults living in areas of hyper- to holoendemicity should be understood with a view toward duplicating such protection in infants and young children in areas of endemicity.

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Cortisol and susceptibility to malaria during pregnancy

Cited by 49 publications

References 47 publications

Prevalence of Malaria in Pregnant Women Attending Ante Natal Care at University of Port Harcourt Primary Health Care Centre Aluu, Port Harcourt, Rivers State, Nigeria

Prevalence of Malaria in Pregnant Women Attending Ante Natal Care at University of Port Harcourt Primary Health Care Centre Aluu, Port Harcourt, Rivers State, Nigeria

Interactions Between Natural Killer Cells, Cortisol and Prolactin in Malaria During Pregnancy

Acquired Immunity to Malaria

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