Glucocorticoids Affect Male Testicular Steroidogenesis

Hampl, Richard; Stárka, L

doi:10.33549/physiolres.934508

Cited by 10 publications

(7 citation statements)

References 29 publications

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“…Among these, the metabolism of purines are involved in cellular translation processes and sperm motility for generation F1 [ 50 , 51 ]. Glucocorticoids involved in steroidogenesis [ 52 ], but also in sugar metabolism, immune function and inflammatory processes, appears as a discriminant metabolite in this first generation [ 53 ].…”

Section: Discussionmentioning

confidence: 99%

Multigenerational Exposure to Uranium Changes Sperm Metabolome in Rats

Grison

Legendre

Svilar

et al. 2022

IJMS

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Male infertility is a major public health issue that can be induced by a host of lifestyle risk factors such as environment, nutrition, smoking, stress, and endocrine disruptors. Regarding the human population exposed to uranium, it is necessary to explore these effects on male reproduction in multigenerational studies. The sensitivity of mass spectrometry (MS)-based methods has already proved to be extremely useful in metabolite identification in rats exposed to low doses of uranium, but also in human sperm. We applied this method to rat sperm over three generations (F0, F1 and F2) with multigenerational uranium exposure. Our results show a significant content of uranium in generation F0, and a reduction in the pregnancy rate only in generation F1. Based on principal component analysis (PCA), we observed discriminant profiles between generations. The partial least squares discriminant analysis (PLS-DA) of the 48 annotated variables confirmed that parental exposure of generation F0 (during both the preconceptional and prenatal periods) can have metabolic effects on spermatozoa for the next two generations. Metabolomics applied to epididymal spermatozoa is a novel approach to detecting the multigenerational effects of uranium in an experimental model, but could be also recommended to identify potential biomarkers evaluating the impact of uranium on sperm in exposed infertile men.

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Section: Discussionmentioning

confidence: 99%

Multigenerational Exposure to Uranium Changes Sperm Metabolome in Rats

Grison

Legendre

Svilar

et al. 2022

IJMS

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“…Moreover, glucocorticoids suppress testosterone produced by Leydig cells causing apoptosis of Leydig cells and disrupting spermatozoa maturation and motility. A study by Hampl and Starka showed that sleep deprivation increases serum glucocorticoid levels after one day, three days, and five days compared to control 14 .…”

Section: Spermatozoa Motilitymentioning

confidence: 97%

Total Sleep Deprivation Reduces Quality of Spermatozoa in Male Albino Rat (Rattus norvegicus)

2023

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Sleep deprivation-induced stress decreases the quality of spermatozoa due to the increase of glucocorticoid levels through the hypothalamic-pituitary-adrenal axis. Sleep recovery (SR) restores the effect of stress due to sleep deprivation by decreasing lipid peroxides and other free radicals and increasing glutathione antioxidants. This study aims to determine the spermatozoa quality in male albino rats (Rattus norvegicus) after the stress induction by diverse sleep deprivation protocols. This study is experimental research with posttest-only control group design in 30 male albino rats divided into five groups consisting of group I for negative control (no induction of sleep deprivation), group II for paradoxical sleep deprivation (PSD), group III for total sleep deprivation (TSD), group IV for PSD followed by SR, and group V for TSD followed by SR. PSD and TSD were performed by depriving rats sleep for 20 and 24 hours/day, respectively, for five days. SR was done for the next five days after PSD or TSD. Shapiro-Wilk test was used for normality of data distribution, and Levene's test was used for variance homogeneity. Comparative hypothesis was then analyzed with One Way Analysis of Variance (ANOVA) test, and significance between groups was analyzed with Tukey's Post-Hoc test. Group III (TSD) demonstrated the lowest mean of spermatozoa count (41,53±2,29), spermatozoa morphology (13,00±2,91), spermatozoa viability (31,00±7,39), and percentage of motility rate (37±8,58%) among all groups. In conclusion, total sleep deprivation (TSD) decreases the quality of spermatozoa in male albino rats (Rattus norvegicus).

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“…Adverse effects of endogenous (e.g., stress-induced) or exogenous glucocorticoid (GC) excess on male reproduction are well established in experimental as well as clinical studies. 1 Exogenous GCs are among important drugs that are administered for different indications especially as anti-inflammatory or immuno-suppressive agents in human and veterinary patients.…”

Section: Introductionmentioning

confidence: 99%

“…Adverse effects of endogenous (e.g., stress‐induced) or exogenous glucocorticoid (GC) excess on male reproduction are well established in experimental as well as clinical studies. 1 …”

Section: Introductionmentioning

confidence: 99%

Effects of pharmacological doses of niacin on subacute glucocorticoid‐induced testicular damage in rats

Azimi Zangabad,

Shomali,

Roshangar

2023

Pharmacology Res & Perspec

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Glucocorticoid excess adversely affects male reproduction. This study evaluates effects of pharmacological doses of niacin on testicular structure and function in dexamethasone‐treated rats. Adult rats (48) were randomly assigned to 6 equal groups: (1) Negative control (NC): normal rats; (2) Positive control (PC): dexamethasone at 7 mg/kg/day by intraperitoneal injections for 7 days; groups 3–6 (N50, N100, N200, and N400): dexamethasone and concomitant treatment with niacin at 50, 100, 200, and 400 mg/kg/day by oral gavages. Testicular weight and volume of PC rats were significantly lower than the NC group (p < .05). Testicular volume of rats in the N50 and N200 groups was statistically similar to the NC group. Significant decreases in serum testosterone with a slight LH increase were detected in the PC group. Nacin at 50 mg/kg reversed serum testosterone to NC levels and increased serum LH concentration. Niacin only slightly increased epididymal spermatozoa number while all groups of niacin‐treated rats had significantly higher percentages of motile spermatozoa compared with the PC group. Hypospermatogenesis, germ cell degeneration and depletion, epithelial vacuolization, and degenerated Leydig cells were observed in PC rats. Lesions were relatively milder in niacin‐treated rats. Johnsen scores were also significantly higher in niacin‐treated rats. Niacin reduced apoptosis as shown by TUNEL assay. In conclusion, niacin administration at pharmacological doses dose‐dependently ameliorates the destructive effects of dexamethasone on sperm motility, Johnsen score, and testicular cell apoptosis in rats with the latter can be considered a decisive mechanism for its positive effects on testis.

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Glucocorticoids Affect Male Testicular Steroidogenesis

Cited by 10 publications

References 29 publications

Multigenerational Exposure to Uranium Changes Sperm Metabolome in Rats

Multigenerational Exposure to Uranium Changes Sperm Metabolome in Rats

Total Sleep Deprivation Reduces Quality of Spermatozoa in Male Albino Rat (Rattus norvegicus)

Effects of pharmacological doses of niacin on subacute glucocorticoid‐induced testicular damage in rats

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