Glucocorticoid influences on the auditory brain-stem responses in man

Born, Jan; Schwab, R; Pietrowsky, Reinhard; Pauschinger, P.; Fehm, Horst L.

doi:10.1016/0013-4694(89)90007-2

Cited by 14 publications

(4 citation statements)

References 17 publications

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“…There is limited literature about the direct effect of glucocorticosteroids on auditory brainstem responses in humans. 14,15 In adults, hydrocortisone administration was shown to acutely reduce absolute latencies, but there was no longterm follow-up assessment. We previously demonstrated that there was no significant difference in auditory neural maturation between premature infants who were exposed to antenatal steroids and infants who were not exposed to antenatal steroids as measured by the ABR within 24 hours of birth.…”

mentioning

confidence: 98%

Auditory Neural Maturation After Exposure to Multiple Courses of Antenatal Betamethasone in Premature Infants as Evaluated by Auditory Brainstem Response

Amin

Guillet

2007

Pediatrics

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mentioning

confidence: 98%

Auditory Neural Maturation After Exposure to Multiple Courses of Antenatal Betamethasone in Premature Infants as Evaluated by Auditory Brainstem Response

Amin

Guillet

2007

Pediatrics

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“…It is unknown whether these changes are pathologic. Regarding functional aspects of the inner ear, however, glucocorticoid intake was reported to induce an elevated threshold of human auditory evoked responses (34,35).…”

Section: Discussionmentioning

confidence: 99%

Effects of Glucocorticoids on the Inner Ear

Takeda

Kakigi

2021

Front. Surg.

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Hypothesis: Recently, several lines of evidence have suggested that the inner ear is under hormonal control. It is likely that steroids have some influence on the inner ear.Background: Many clinicians have been empirically using steroids for the treatment of diseases associated with endolymphatic hydrops. The theoretical grounds for this are not clear, and there have been a number of debates on the effectiveness of steroid treatment. Furthermore, there are few reports on histological observations of the influences of steroids on the cochlea.Method: Fifteen guinea pigs (30 ears) were divided into three groups. In the control group, physiological saline solution was administered intra-peritoneally for 3 days. In two steroid groups, 40 mg/kg/day of hydrocortisone or 4 mg/kg/day of dexamethasone was administered intra-peritoneally for 3 days. Extension of Reissner's membrane and volume change of the scala media were checked 6 h after the last administration. The degree of Reissner's membrane extension and volumetric change of the scala media were quantitatively measured with the use of a video-digitizer.Results: We did not identify any distinct changes in the cochlea of the control group. In contrast, the extension of Reissner's membrane and endolymphatic hydrops were observed in the animals in the steroid groups. Statistical analysis revealed that Reissner's membrane extended significantly in the steroid groups, and that the volume of the scala media also increased significantly.Conclusion: This is the first report to investigate the effects of systemic administration of glucocorticoids on guineapig cochlea. The extension of Reissner's membrane and dilated endolymphatic space were evident in the steroid groups. However, the underlying mechanism of histological changes was not clear, marked care needs to be taken when administering steroids to patients with Meniere's disease whose histological feature is endolymphatic hydrops.

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“…This seems to contradict a study in goldfish in which noise exposure rapidly increases in cortisol levels while reducing auditory brainstem response and increasing threshold, although this study also highlighted the complexity of this possible interaction (Smith et al, 2004 ). Acute administration of corticosteroids in humans has also been shown to modulate multiple sensory modalities, as measured by auditory hearing threshold (Beckwith et al, 1983 ; Fehm-Wolfsdorf and Nagel, 1996 ), taste perception (Henkin, 1970 ; Fehm-Wolfsdorf et al, 1989 ), and electroencephalogram (EEG) activity (Born et al, 1988 , 1989 ). The general effect of cortisol on multi-modal sensory pathways supports our interpretation that our results reflect cortisol-induced changes in sensory integration and not differences in activity within the 8th nerve afferences that project to the M-cell, although direct recordings would be required to confirm this possibility.…”

Section: Discussionmentioning

confidence: 99%

Cellular Mechanisms of Cortisol-Induced Changes in Mauthner-Cell Excitability in the Startle Circuit of Goldfish

Bronson

Preuss

2017

Front. Neural Circuits

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Predator pressure and olfactory cues (alarm substance) have been shown to modulate Mauthner cell (M-cell) initiated startle escape responses (C-starts) in teleost fish. The regulation of such adaptive responses to potential threats is thought to involve the release of steroid hormones such as cortisol. However, the mechanism by which cortisol may regulate M-cell excitability is not known. Here, we used intrasomatic, in vivo recordings to elucidate the acute effects of cortisol on M-cell membrane properties and sound evoked post-synaptic potentials (PSPs). Cortisol tonically decreased threshold current in the M-cell within 10 min before trending towards baseline excitability over an hour later, which may indicate the involvement of non-genomic mechanisms. Consistently, current ramp injection experiments showed that cortisol increased M-cell input resistance in the depolarizing membrane, i.e., by a voltage-dependent postsynaptic mechanism. Cortisol also increases the magnitude of sound-evoked M-cell PSPs by reducing the efficacy of local feedforward inhibition (FFI). Interestingly, another pre-synaptic inhibitory network mediating prepulse inhibition (PPI) remained unaffected. Together, our results suggest that cortisol rapidly increases M-cell excitability via a post-synaptic effector mechanism, likely a chloride conductance, which, in combination with its dampening effect on FFI, will modulate information processing to reach threshold. Given the central role of the M-cell in initiating startle, these results are consistent with a role of cortisol in mediating the expression of a vital behavior.

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Glucocorticoid influences on the auditory brain-stem responses in man

Cited by 14 publications

References 17 publications

Auditory Neural Maturation After Exposure to Multiple Courses of Antenatal Betamethasone in Premature Infants as Evaluated by Auditory Brainstem Response

Auditory Neural Maturation After Exposure to Multiple Courses of Antenatal Betamethasone in Premature Infants as Evaluated by Auditory Brainstem Response

Effects of Glucocorticoids on the Inner Ear

Cellular Mechanisms of Cortisol-Induced Changes in Mauthner-Cell Excitability in the Startle Circuit of Goldfish

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