Glucocorticoid entrapment into lipid carriers — characterisation by parelectric spectroscopy and influence on dermal uptake

Sivaramakrishnan, R.; Nakamura, Chie; Mehnert, W.; Hc, Korting; Kramer, K.D.; Schäfer‐Korting, Monika

doi:10.1016/j.jconrel.2004.04.001

Cited by 76 publications

(20 citation statements)

References 24 publications

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“…In general, the use of crystallized lipids instead of liquid lipids has been shown to increase control over release and stability of incorporated bioactives. This is because mobility of bioactives can be controlled by controlling the physical state of the lipid matrix [63][64][65][66][67] (Figure 1). …”

Section: Solid Lipid Nanoparticlesmentioning

confidence: 99%

Solid Lipid Nanoparticles as Delivery Systems for Bioactive Food Components

et al. 2008

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The inclusion of bioactive compounds, such as carotenoids, omega-3 fatty acids, or phytosterols, is an essential requisite for the production of functional foods designed to improve the long-term health and well-being of consumers worldwide. To incorporate these functional components successfully in a food system, structurally sophisticated encapsulation matrices have to be engineered, which provide maximal physical stability, protect ingredients against chemical degradation, and allow for precise control over the release of encapsulated components during mastication and digestion to maximize adsorption. A novel encapsulation system initially developed in the pharmaceutical industries to deliver lipophilic bioactive compounds is solid lipid nanoparticles (SLN). SLN consist of crystallized nanoemulsions with the dispersed phase being composed of a solid carrier lipid-bioactive ingredient mixture. Contrary to larger colloidal solid lipid particles, specific crystal structures can be "dialed-in" in SLN by using specific surfactant mixtures and ensuring that mean particle sizes are below 100-200 nm. Moreover, in SLN, microphase separations of the bioactive compound from the solidifying lipid matrix can be prevented resulting in an even dispersion of the encapsulated compound in the solid matrix thereby improving chemical and physical stability of the bioactive. In this review article, we will briefly introduce the structure, properties, stability, and manufacturing of solid lipid particles and discuss their emerging use in food science.

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Section: Solid Lipid Nanoparticlesmentioning

confidence: 99%

Solid Lipid Nanoparticles as Delivery Systems for Bioactive Food Components

et al. 2008

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“…Firstly, the mobility of reactive agents in a solid matrix is lower than in a liquid matrix and so the rate of chemical degradation reactions may be retarded. Secondly, microphase separations of the active ingredients and carrier lipid within individual liquid particles can be controlled, thereby preventing the accumulation of active compounds at the surface of lipid particles where chemical degradation reactions often occur [8][9][10][11][12][13]. Thirdly, incorporation of poorly absorbed bioactive compounds into solid lipid nanoparticles has been shown to improve their biological absorption [14,15].…”

Section: Introductionmentioning

confidence: 99%

Effect of surfactant surface coverage on formation of solid lipid nanoparticles (SLN)

Helgason

Awad

Kristbergsson

et al. 2009

Journal of Colloid and Interface Science

284

161

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“…Solid lipid nanoparticles containing 0.1% betamethasone valerate (BMV) were developed by Sivaramakrishnan et al (2004), [97] using high pressure homogenization. The system was composed by 12.5% compritol 888 and 3% Poloxamer 188 (SLN A), precirol 12.5 and 3% polysorbate 80 (SLN B).…”

Section: Solid Lipid Nanoparticles (Sln) and Nanostructured Lipid Carmentioning

confidence: 99%

Nanotechnology-Based Drug Delivery Systems for Treatment of Hyperproliferative Skin Diseases - A Review

Santos¹,

Oyafuso²,

Kiill³

et al. 2013

Current Nanoscience

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The chronic hyperproliferative diseases (CHD) include cancer, precancerous lesions and diseases of unknown etiology such as psoriasis. Various drugs have been used in the treatment of CHD, such as antiproliferative and corticosteroids in general. However, some drugs have properties that limit their effectiveness, such as low solubility in water and low penetration of the skin. Thus, the control of drug release in the skin may improve efficacy and reduce side effects of many drugs used in hyperproliferative diseases. The purpose of this study was to make a systematic review of nanotechnology-based drug delivery systems used against hyperproliferative skin diseases.

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Glucocorticoid entrapment into lipid carriers — characterisation by parelectric spectroscopy and influence on dermal uptake

Cited by 76 publications

References 24 publications

Solid Lipid Nanoparticles as Delivery Systems for Bioactive Food Components

Solid Lipid Nanoparticles as Delivery Systems for Bioactive Food Components

Effect of surfactant surface coverage on formation of solid lipid nanoparticles (SLN)

Nanotechnology-Based Drug Delivery Systems for Treatment of Hyperproliferative Skin Diseases - A Review

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