Abstract:Gastric glomus tumor is a rare mesenchymal tumor of the gastrointestinal tract, accounting for approximately 1% of all gastrointestinal soft tissue tumors. We describe a unique case of a 27-year-old female patient who presented with recurrent episodes of overt gastrointestinal bleeding requiring multiple blood transfusions. The patient was diagnosed with a gastric ulcer detected on esophagogastroduodenoscopy (EGD), which was grossly suggestive of an ulcerated gastrointestinal stromal tumor (GIST). Preoperative… Show more
“…Glomangioma (20%) is a form in which a venous proliferation (cavernous hemangioma appearance) is observed surrounded by nests of glomus cells. Glomangiomyoma (5%) is characterized by the presence of elongated glomus cells, with an appearance similar to smooth muscle cells [ 2 , 24 ].…”
Patient: Male, 65-year-old
Final Diagnosis: Gastric glomus tumor
Symptoms: Gastric hemorrhage
Clinical Procedure: —
Specialty: Pathology
Objective:
Rare disease
Background:
Glomus tumor is a benign but rapidly growing mesenchymal tumor that is a rare in the gastrointestinal tract, can be locally invasive due to its rapid growth, and can result in perforation of a viscus. We report a 65-year-old man presenting as an emergency with gastric hemorrhage and gastric glomus tumor.
Case Report:
A 65-year-old man came to our hospital for a life-threatening upper digestive hemorrhage. The preoperative examinations (digestive endoscopy without sampling of biopsy fragments and contrast-enhanced computer tomography) led to the presumptive diagnosis of gastrointestinal stromal tumor. Wedge resection of the gastric wall was performed. The histopathological examinations revealed a proliferation of round-oval cells of medium size with a solid disposition and in nests. This proliferation dissected the muscular tunic and caused ulceration of the gastric mucosa. Immunohistochemical tests confirmed the diagnosis of glomus tumor and excluded other diagnoses (neuroendocrine tumor or gastrointestinal stromal tumor). The postoperative evolution was favorable, and at the time of discharge, the biochemical test values normalized.
Conclusions:
Pathologists are faced with a challenging task due to the deceptive appearance that can be presented by such a rare tumor. Histopathological and immunohistochemical examinations are essential in achieving a precise diagnosis and assessing the biological potential of the glomus tumor. Even if it is a benign tumor, the clinical picture it causes can still be a major risk to the patient’s life. Consequently, ensuring effective case management becomes crucial, as it requires a thorough comprehension of all conditions encompassed in the differential diagnosis.
“…Glomangioma (20%) is a form in which a venous proliferation (cavernous hemangioma appearance) is observed surrounded by nests of glomus cells. Glomangiomyoma (5%) is characterized by the presence of elongated glomus cells, with an appearance similar to smooth muscle cells [ 2 , 24 ].…”
Patient: Male, 65-year-old
Final Diagnosis: Gastric glomus tumor
Symptoms: Gastric hemorrhage
Clinical Procedure: —
Specialty: Pathology
Objective:
Rare disease
Background:
Glomus tumor is a benign but rapidly growing mesenchymal tumor that is a rare in the gastrointestinal tract, can be locally invasive due to its rapid growth, and can result in perforation of a viscus. We report a 65-year-old man presenting as an emergency with gastric hemorrhage and gastric glomus tumor.
Case Report:
A 65-year-old man came to our hospital for a life-threatening upper digestive hemorrhage. The preoperative examinations (digestive endoscopy without sampling of biopsy fragments and contrast-enhanced computer tomography) led to the presumptive diagnosis of gastrointestinal stromal tumor. Wedge resection of the gastric wall was performed. The histopathological examinations revealed a proliferation of round-oval cells of medium size with a solid disposition and in nests. This proliferation dissected the muscular tunic and caused ulceration of the gastric mucosa. Immunohistochemical tests confirmed the diagnosis of glomus tumor and excluded other diagnoses (neuroendocrine tumor or gastrointestinal stromal tumor). The postoperative evolution was favorable, and at the time of discharge, the biochemical test values normalized.
Conclusions:
Pathologists are faced with a challenging task due to the deceptive appearance that can be presented by such a rare tumor. Histopathological and immunohistochemical examinations are essential in achieving a precise diagnosis and assessing the biological potential of the glomus tumor. Even if it is a benign tumor, the clinical picture it causes can still be a major risk to the patient’s life. Consequently, ensuring effective case management becomes crucial, as it requires a thorough comprehension of all conditions encompassed in the differential diagnosis.
“…Though the first clinical description of a glomus tumor was reported in 1812 by Wood, as a painful subcutaneous tubercle, 40 the histopathological features of the glomus tumor and its emergence from the glomus body were not described until 1924 by Barre and Masson. 41 There is no clear understanding of the factors influencing the pathogenesis of glomus tumors and their etiology, including age at onset, gender, family predisposition, and history of trauma to the site. 42 Most cases of delayed diagnosis of GT, which could be between 3-15 years, [43][44][45] were due to a lack of awareness about the disease among the general practitioners who usually receive the patients initially, its anatomical presentation and visibility.…”
A glomus tumor (GT) is a rare and usually benign tumor that originates from the glomus body, which is involved in thermoregulation in the skin. Solitary or multiple, digital or extra-digital, these cutaneous tumors can be benign or malignant. This report describes the diagnosis and surgical management of a solitary glomus tumor at the base of the right thumb in a young Sudanese woman. The diagnosis of glomus tumor was confirmed by medical history, sonographic findings and histopathological report. The lesion was excised via direct complete excision under local anesthesia, resulting in a complete resolution of symptoms. Owing to its high sensitivity level, the use of ultrasound is appropriate to evaluate a lesion suspected to be a glomus tumor. A clinician needs to take into consideration the likelihood of glomus tumors when assessing a patient who has a skin lesion on fingers, toes, or extra-digital area, with pain triggered by temperature changes, pressure, or touch. Additionally, this report includes a review of recent globally reported cases of glomus tumor in the hand to highlight the distinctiveness of this report in context to its atypical location in the area of the thenar eminence and underscoring it as a unique report of its kind from Saudi Arabia.
Background: Glomus tumors (GTs) are mesenchymal neoplasms that are typically benign. Gastric GTs are uncommon and occur mostly in the upper gastrointestinal tract. Malignant gastric GTs are exceedingly rare, constituting fewer than 1% of gastric tumors. Because their features are similar to those of other tumors found in the same gastrointestinal region, such as stromal tumors, leiomyomas, lymphomas, and lipomas, diagnosis is challenging.
Case Presentation: A 52-year-old male patient presented with fatigue and melena. Initial endoscopic examinations failed to locate any source of bleeding. Six months later, pan-gastroscopy, performed because of progressive microcytic anemia, revealed a 40 ´ 30 mm polypoid lesion with deep ulcerations; histopathological analysis confirmed that it was a gastric GT with alpha-actin and cadherin 17 expression and a Ki-67 index of 20%. The patient delayed surgical therapy until his symptoms worsened. Laparoscopic sleeve resection revealed a 65 ´ 45 ´25 mm tumor, and secondary immunohistochemical analysis revealed extensive spread into the mucosa and subserosa. Focally, the tumor bulged into some large veins. Genetic examination with RNA isolation further supported the histopathological diagnosis of gastric GT with uncertain malignant potential.
Conclusions: This case underscores the diagnostic challenges posed by gastric GTs because they are rare and their clinical features are similar to those of other gastric tumors. Thorough histopathological and molecular analysis are essential for accurate diagnosis. Surgical intervention remains the primary therapeutic approach. This case also emphasizes the need for long-term followup because of the potential for recurrence and for malignancy.
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