Glomerular Cell Biology

Maezawa, Yoshiro; Cinà, Davide P.; Quaggin, Susan E.

doi:10.1016/b978-0-12-381462-3.00022-7

Cited by 11 publications

(7 citation statements)

References 306 publications

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“…Current models suggest that all three layers of the filtration barrier are likely important (including the glycocalyx of the endothelial layer), but relative contributions remain unknown. [77] Using cysteine-coated zwitterionic CdSe/ZnS quantum dots, it was established that inorganic NPs with hydrodynamic diameter D ≤ 5.5 nm are cleared through the kidneys of healthy rats, [19] a size cutoff similar to the accepted 6-nm limit for proteins. [78] Many subsequent reports showed renal clearance of NPs with D ⪅ 6 nm, [35] including ZDS-coated FeOx NPs.…”

Section: Biodistribution Of Zds/feox Nps In Micementioning

confidence: 99%

Towards bio-compatible magnetic nanoparticles: Immune-related effects, in-vitro internalization, and in-vivo bio-distribution of zwitterionic ferrite nanoparticles with unexpected renal clearance

Ferretti¹,

Usseglio²,

Mondini³

et al. 2021

Journal of Colloid and Interface Science

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Section: Biodistribution Of Zds/feox Nps In Micementioning

confidence: 99%

Towards bio-compatible magnetic nanoparticles: Immune-related effects, in-vitro internalization, and in-vivo bio-distribution of zwitterionic ferrite nanoparticles with unexpected renal clearance

Ferretti¹,

Usseglio²,

Mondini³

et al. 2021

Journal of Colloid and Interface Science

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“…Glomerular endothelial cells are highly fenestrated, with 50- to 80-nm pores that go through the cytoplasm 5 . The luminal surface of endothelial cells is covered by a thick layer of glycocalyx that includes proteoglycans (PGs), such as syndecan, glypican, perlecan and versican, as well as their glycosaminoglycan (GAG) side chains, heparan sulfate and chondroitin sulfate 6 .…”

Section: Glomerular Endothelial Cellsmentioning

confidence: 99%

Cell biology of diabetic nephropathy: Roles of endothelial cells, tubulointerstitial cells and podocytes

Maezawa

Takemoto

Yokote

2014

J of Diabetes Invest

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165

132

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Diabetic nephropathy is the major cause of end-stage renal failure throughout the world in both developed and developing countries. Diabetes affects all cell types of the kidney, including endothelial cells, tubulointerstitial cells, podocytes and mesangial cells. During the past decade, the importance of podocyte injury in the formation and progression of diabetic nephropathy has been established and emphasized. However, recent findings provide additional perspectives on pathogenesis of diabetic nephropathy. Glomerular endothelial damage is already present in the normoalbuminuric stage of the disease when podocyte injury starts. Genetic targeting of mice that cause endothelial injury leads to accelerated diabetic nephropathy. Tubulointerstitial damage, previously considered to be a secondary effect of glomerular protein leakage, was shown to have a primary significance in the progression of diabetic nephropathy. Emerging evidence suggests that the glomerular filtration barrier and tubulointerstitial compartment is a composite, dynamic entity where any injury of one cell type spreads to other cell types, and leads to the dysfunction of the whole apparatus. Accumulation of novel knowledge would provide a better understanding of the pathogenesis of diabetic nephropathy, and might lead to a development of a new therapeutic strategy for the disease.

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“…This review aims to highlight recent discoveries of signaling systems that mediate intraglomerular crosstalk. [2]…”

Section: Introductionmentioning

confidence: 99%

Crosstalk in glomerular injury and repair

Dimke

Maezawa

Quaggin³

2015

Current Opinion in Nephrology and Hypertension

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Purpose of review The glomerulus is a unique structure required for filtration of blood, while retaining plasma proteins based on size and charge selectivity. Distinct cell types form the structural unit that creates the filtration barrier. Structurally, fenestrated endothelial cells line the capillary loops and lie in close contact with mesangial cells. Podocytes are connected by specialized intercellular junctions known as slit diaphragms and are separated from the endothelial compartment by the glomerular basement membrane. In order for this highly specialized structure to function, cross-communication between these cells must occur. Recent findings While classical studies have established key roles for vascular endothelial- and platelet derived-growth factors in glomerular cross-communication, novel paracrine signaling pathways within the glomerulus have recently been identified. In addition, unique cellular pathways of established signaling cascades have been identified that are important for maintaining glomerular barrier function in health and disease. Summary Here, we will review our current understanding of the processes of cross-communication between the unique cellular constituents forming the glomerular filtration unit. We will highlight recent findings of cellular crosstalk via signaling pathways that regulate glomerular barrier function in pathophysiological conditions.

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Glomerular Cell Biology

Cited by 11 publications

References 306 publications

Towards bio-compatible magnetic nanoparticles: Immune-related effects, in-vitro internalization, and in-vivo bio-distribution of zwitterionic ferrite nanoparticles with unexpected renal clearance

Towards bio-compatible magnetic nanoparticles: Immune-related effects, in-vitro internalization, and in-vivo bio-distribution of zwitterionic ferrite nanoparticles with unexpected renal clearance

Cell biology of diabetic nephropathy: Roles of endothelial cells, tubulointerstitial cells and podocytes

Crosstalk in glomerular injury and repair

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