“…Of these six cases with splenomegaly, three showed a neutropenia, with lack of neutrophil response during the infections, and three had an acquired hiemolytic anaemia; in two of the latter patients splenectomy was performed with relief of the aniemia in each case. Further instances of associated hypersplenism and heemolytic aniemia in the acquired type of gammaglobulin deficiency have been published by Prasad and Koza (1954, the first case described), Prasad, Reiner and Watson (1957, one additional case) and by Standaert and De Moor (1955), Martin, Gordon andMcCullough (1956), andBriickel, Neuffer andFrankel (1956) (each a single case), this series likewise including two patients subjected to splenectomy, with recovery in one and death from bronchopneumonia in the second. A total of eight cases of hypogammaglobulinaemia with hiemolytic anwmia has thus been traced in the medical literature.…”