Globulin Fractions Separated From Antipertussis Rabbit Serum

Kendrick, Pearl L.; Eldering, Grace; Ling, Nan-Sing

doi:10.1080/00039896.1970.10667256

Cited by 1 publication

(2 citation statements)

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“…IgG antibody is antibacterial and fluorescence showed that the four classes of passively protective for mice against B. VOL. 8,1973 pertussis (4,7). The mechanism of IgA action has not been fully explained.…”

Section: Discussionmentioning

confidence: 99%

“…Dolby and Dolby, (4) reported that 7S and 19S globulins mixed with challenge culture were equally effective against lung infection in the mouse, whereas 7S was 100 times more effective than 19S against brain infection. Kendrick et al (7) likewise found that the protective activity against the brain infection was in the immunoglobulin class G (IgG) fraction of rabbit Ig. The effectiveness of the different classes of Ig in man has not been studied adequately.…”

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confidence: 99%

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Immunoglobulin and Histamine-Sensitivity Response of Mice to Live Bordetella pertussis

Geller

Pittman

1973

Infect Immun

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Mice injected intranasally (it.n.) and intraperitoneally (i.p.) with a nonlethal dose (2.5 x 105 colony-forming units) of live Bordetella pertussis were examined for 50 days for infection, respiratory tract immunoglobulins (Ig), changes in serum Ig, and histamine sensitivity. With mice infected it.n., respiratory infection markedly declined between day 20 and day 30. Ig classes (A, Gl, G25, G2b, but no M), which had specificity for B. pertussis, were present in tracheobronchial wash (TBW) by day 15; by day 50, TBW immunodiffusion and immunoelectrophoretic precipitin bands were more intense. A sharp rise in serum IgA after day 30 was the only significant change relative to controls among the five serum Ig examined. A high degree of histamine sensitivity developed by day 15 to 20 and persisted for the 50 days. With mice inoculated i.p., no bacteria were recovered, no Ig or only traces were found in TBW and IgA only was specific, and no significant changes in the serum Ig relative to controls occurred. Histamine sensitivity developed somewhat more slowly and to a lesser degree than in it.n.-injected mice but persisted for the 50 days. A similar small number of killed bacteria (pertussis vaccine) injected it.n. or i.p. likewise induced slowly developing histamine sensitivity in contrast to published reports of 4 to 5 day peak sensitivity and decline following i.p. injection of 109 or more killed bacteria.

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Section: Discussionmentioning

confidence: 99%

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confidence: 99%