Globular Shaped Polypyrrole Doped Well-Dispersed Functionalized Multiwall Carbon Nanotubes/Nafion Composite for Enzymatic Glucose Biosensor Application

Shrestha, Bishnu Kumar; Ahmad, Rafiq; Shrestha, Sita; Park, Chan Hee; Kim, Cheol Sang

doi:10.1038/s41598-017-16541-9

Cited by 56 publications

(38 citation statements)

References 60 publications

(50 reference statements)

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“…Efforts to improve sensitivity have involved the incorporation of organic and inorganic nanoparticles into the ICP matrix. For instance, Chan Hee Park, Cheol Sang Kim and their co-workers prepared a bio-nanohybrid material based on PPy hydrogel with incorporated functionalized multiwall carbon nanotubes ( f MWCNTs) in Nafion (Nf), followed by one-step in situ electrochemical polymerization (Figure 6A) [238]. The enzymatic PPy hydrogel / f MWCNT/Nf electrode, which was prepared following the steps presented in Figure 6A, showed good selectivity, stability and excellent electrocatalytic performance to detect glucose with a high sensitivity (54.2 μA mM −1 cm −2 ) in a linear range of up to 4.1 mM as well as a low detection limit of 5 μM (S/N = 3) [238].…”

Section: Bioapplications Of Conducting Polymers Conductive Hydrogmentioning

confidence: 99%

Conducting Polymers, Hydrogels and Their Composites: Preparation, Properties and Bioapplications

2019

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This review is focused on current state-of-the-art research on electroactive-based materials and their synthesis, as well as their physicochemical and biological properties. Special attention is paid to pristine intrinsically conducting polymers (ICPs) and their composites with other organic and inorganic components, well-defined micro- and nanostructures, and enhanced surface areas compared with those of conventionally prepared ICPs. Hydrogels, due to their defined porous structures and being filled with aqueous solution, offer the ability to increase the amount of immobilized chemical, biological or biochemical molecules. When other components are incorporated into ICPs, the materials form composites; in this particular case, they form conductive composites. The design and synthesis of conductive composites result in the inheritance of the advantages of each component and offer new features because of the synergistic effects between the components. The resulting structures of ICPs, conducting polymer hydrogels and their composites, as well as the unusual physicochemical properties, biocompatibility and multi-functionality of these materials, facilitate their bioapplications. The synergistic effects between constituents have made these materials particularly attractive as sensing elements for biological agents, and they also enable the immobilization of bioreceptors such as enzymes, antigen-antibodies, and nucleic acids onto their surfaces for the detection of an array of biological agents. Currently, these materials have unlimited applicability in biomedicine. In this review, we have limited discussion to three areas in which it seems that the use of ICPs and materials, including their different forms, are particularly interesting, namely, biosensors, delivery of drugs and tissue engineering.

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Section: Bioapplications Of Conducting Polymers Conductive Hydrogmentioning

confidence: 99%

Conducting Polymers, Hydrogels and Their Composites: Preparation, Properties and Bioapplications

2019

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“…31,32 PPY biomaterials has been further modified by creating specific topographies, incorporating biomolecules (e.g., peptides, proteins, and polysaccharides), and modulating mechanical properties to improve their biological interactions. 28,31,33,34 Despite the unique benefits of CP-modified electrodes, their biocompatibility is often compromised by electrochemical functions (e.g. thick CP coatings can decrease the electrical impedance of electrodes but lead to poor cell attachment and growth).…”

Section: Introductionmentioning

confidence: 99%

Electrically Conductive Polydopamine–Polypyrrole as High Performance Biomaterials for Cell Stimulation in Vitro and Electrical Signal Recording in Vivo

Kim¹,

Jang²,

Jang³

et al. 2018

ACS Appl. Mater. Interfaces

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Conductive polymers (CPs) such as polypyrrole (PPY) are emerging biomaterials for use as scaffolds and bioelectrodes which interact with biological systems electrically. Still, more electrically conductive and biologically interactive CPs are required to develop high performance biomaterials and medical devices. In this study, in situ electrochemical copolymerization of polydopamine (PDA) and PPY were performed for electrode modification. Their material and biological properties were characterized using multiple techniques. The electrical properties of electrodes coated with PDA/PPY were superior to electrodes coated with PPY alone. The growth and differentiation of C2C12 myoblasts and PC12 neuronal cells on PDA/PPY was enhanced compared to PPY. Electrical stimulation of PC12 cells on PDA/PPY further promoted neuritogenesis. In vivo electromyography signal measurements demonstrated more sensitive signals from tibia muscles when using PDA/PPY-coated electrodes than bare or PPY-coated electrodes, revealing PDA/PPY to be a high-performance biomaterial with potential for various biomedical applications.

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“…Another problem encountered in classical biosensors is that a high anodic potential (exceeding +0.6 V) is applied, leading to interference from other oxidizable substances, such as ascorbic acid, acetaminophen or uric acid. To solve this problem of interferences, it is possible to add to the sensitive layer of the biosensor a polymeric membrane (for example in Nafion or polyphenol) permeable to glucose and hydrogen peroxide but impermeable to the interfering species [101,102]. Similarly, electrocatalysts for reduction of hydrogen peroxide, such as Prussian Blue, can be used to lower reduction potential of H 2 O 2 and solve the selectivity problem.…”

Section: Conducting Polymer-based Enzyme Biosensorsmentioning

confidence: 99%

Electrochemical Biosensors Based on Conducting Polymers: A Review

Lakard

2020

Applied Sciences

114

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Conducting polymers are an important class of functional materials that has been widely applied to fabricate electrochemical biosensors, because of their interesting and tunable chemical, electrical, and structural properties. Conducting polymers can also be designed through chemical grafting of functional groups, nanostructured, or associated with other functional materials such as nanoparticles to provide tremendous improvements in sensitivity, selectivity, stability and reproducibility of the biosensor’s response to a variety of bioanalytes. Such biosensors are expected to play a growing and significant role in delivering the diagnostic information and therapy monitoring since they have advantages including their low cost and low detection limit. Therefore, this article starts with the description of electroanalytical methods (potentiometry, amperometry, conductometry, voltammetry, impedometry) used in electrochemical biosensors, and continues with a review of the recent advances in the application of conducting polymers in the recognition of bioanalytes leading to the development of enzyme based biosensors, immunosensors, DNA biosensors, and whole-cell biosensors.

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Globular Shaped Polypyrrole Doped Well-Dispersed Functionalized Multiwall Carbon Nanotubes/Nafion Composite for Enzymatic Glucose Biosensor Application

Cited by 56 publications

References 60 publications

Conducting Polymers, Hydrogels and Their Composites: Preparation, Properties and Bioapplications

Conducting Polymers, Hydrogels and Their Composites: Preparation, Properties and Bioapplications

Electrically Conductive Polydopamine–Polypyrrole as High Performance Biomaterials for Cell Stimulation in Vitro and Electrical Signal Recording in Vivo

Electrochemical Biosensors Based on Conducting Polymers: A Review

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