Global trends in the prevalence and incidence of depression:a systematic review and meta-analysis

Moreno-Agostino, Darío; Wu, Yu‐Tzu; Daskalopoulou, Christina; Hasan, M. Tasdik; Huisman, Martijn; Prina, Matthew

doi:10.1016/j.jad.2020.12.035

Cited by 179 publications

(114 citation statements)

References 43 publications

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“…Our findings add to this pool of knowledge, which further confirms the pervasiveness and the seriousness of the repercussions of the pandemic on global public mental health. Considering that depression has been identified as a major public health concern by pre-pandemic research [74,75], our findings also highlight the need to urgently prioritize actions to tackle depression linked to the COVID-19 outbreak.…”

Section: Discussionmentioning

confidence: 79%

Traumatic Distress of COVID-19 and Depression in the General Population: Exploring the Role of Resilience, Anxiety, and Hope

Nearchou

Douglas

2021

IJERPH

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International evidence published so far shows that the COVID-19 pandemic has negatively impacted on global mental health. Specifically, there is some research suggesting that the psychological distress related to depression, anxiety and posttraumatic stress has impacted on the psychological well-being of the general population. Yet, there is limited evidence on the relational paths between COVID-19 traumatic distress and depression. Participants of this cross-sectional study were 456 adults 18 years old or older from the general population (Mean age = 41.2 years, SD = 11.7) who completed an online questionnaire including measures assessing depression, anxiety, resilience, hope and traumatic distress related to COVID-19. Structural equation modelling was applied to examine the proposed mediation model. The results confirmed the proposed model, with traumatic distress of COVID-19, resilience, anxiety and hope explaining a considerable amount of variance (59%) in depression scores. Traumatic distress of COVID-19 was a strong positive predictor of depression, while anxiety, hope and resilience were both joint and unique mediators of this relationship. Exposure to the COVID-19 pandemic is strongly associated with depression in adults of the general population. The co-occurrence of anxiety may negatively contribute to experiencing higher levels of depression, while resilience and hope may act as buffers against depression associated with the impact of this pandemic. Our findings suggest that wide community-based interventions designed to promote resilience, build hope and reduce anxiety may help mitigate depression associated with exposure to the COVID-19 pandemic.

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Section: Discussionmentioning

confidence: 79%

Traumatic Distress of COVID-19 and Depression in the General Population: Exploring the Role of Resilience, Anxiety, and Hope

Nearchou

Douglas

2021

IJERPH

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“…On the other hand, a meta-analysis evaluating 5-HTTLPR in relation to antidepressant response reported a predictive value of biallelic but not triallelic genetic variation (Ren et al 2020). Furthermore, a meta-analysis suggested an increasing prevalence of depression over time in the general population (Moreno-Agostino et al 2021). Thus, a lack of gene-environment interactions could be another limitation.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of 5-HTTLPR (insertion/deletion) and BDNF (rs6265) genetic variations in the Slovakian individuals suffering from affective disorders

Bednarova

Čižmáriková²,

Habalová³

et al. 2021

gpb

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The pathophysiology of affective disorders (AD), including depressive disorders (DD) and anxiety disorders (ANXD), is still unclear. To understand risk factors of the disorders, we evaluated genetic variations of the serotonin reuptake transporter (5-HTTLPR, ins/del) and the brain-derived neurotrophic factor (BDNF, rs6265) in Slovak patients suffering from AD. After genotyping we observed a significantly increased frequency of LS and LL genotypes (5-HTTLPR) in individuals diagnosed with AD compared to controls (OR = 1.99, 95% CI = 1.21-3.27, p = 0.006). There was also a significant relationship between TT (BDNF) genotype and the risk of AD in males (OR = 5.93, 95% CI = 1.42-27.07, p = 0.011). In gene-gene analysis, the LL or LS (5-HTTLPR) and CT or TT (BDNF) genotype combinations had a risk-enhancing effect on AD susceptibility (mainly ANXD in males), while SS (5-HTTLPR) and TT (BDNF) combination had a protective effect on AD risk (mainly ANXD). However, larger prospective studies are needed to confirm our findings.

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“…Depression is one of the leading causes of disability and global burden worldwide (Vigo et al, 2016;World Health Organization, 2017). A recent meta-analysis (Moreno-Agostino et al, 2021) shows that there is a predominantly increasing trend in the prevalence of depression in population-based studies using equivalent sampling and depression assessment procedures across time points. This interacts with a global shift in demographics, characterised by an increase in the proportion of the older population worldwide (United Nations, 2017).…”

Section: Introductionmentioning

confidence: 99%

Psychometric properties of the PHQ-9 measure of depression among Brazilian older adults

Moreno-Agostino

Chua

Peters

et al. 2021

Aging & Mental Health

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Objectives: To obtain evidence on the psychometric properties of the Patient Health Questionnaire − 9 (PHQ-9, one of the most extensively used tools for assessing depression) in the Brazilian older population. Method: Data on 3,356 Brazilian adults aged 60+ years living in Guarulhos, São Paulo state were used. The factor structure of the questionnaire was analysed using a factor analysis approach. The questionnaire's measurement equivalence was tested across gender, age, personal income, and education level groups. The scores were compared across groups based on the highest level of equivalence achieved. The questionnaire's internal consistency was analysed considering its factor structure. Results: A one-factor solution was identified as the most adequate factor structure, with the factor explaining 57.6% of the items' variance. The correlation of the resulting latent score with the overall raw sum score in the PHQ-9 was r = 0.96. Measurement equivalence regarding thresholds and loadings was achieved for all tested groups. On average, women, older, less educated, and poorer people had higher latent scores on the depression factor. The measure showed a good internal consistency with Revelle's omega total ω t =0.92. Conclusion:The results suggest that, among Brazilian older adults living in Guarulhos, São Paulo state, the PHQ-9 measures depressive symptomatology equivalently across different sociodemographic subgroups. Moreover, it can be scored using the raw sum of the item scores to adequately reflect different levels of depressive symptomatology.

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Global trends in the prevalence and incidence of depression:a systematic review and meta-analysis

Cited by 179 publications

References 43 publications

Traumatic Distress of COVID-19 and Depression in the General Population: Exploring the Role of Resilience, Anxiety, and Hope

Traumatic Distress of COVID-19 and Depression in the General Population: Exploring the Role of Resilience, Anxiety, and Hope

Evaluation of 5-HTTLPR (insertion/deletion) and BDNF (rs6265) genetic variations in the Slovakian individuals suffering from affective disorders

Psychometric properties of the PHQ-9 measure of depression among Brazilian older adults

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