Global trends in research related to functional dyspepsia and anxiety or depression over the past two decades: a bibliometric analysis

Abstract

Background and purposeFunctional dyspepsia (FD) is a prevalent global disorder of the upper digestive tract characterized by functional impairment. It often coexists with anxiety/depression, significantly impairing occupational productivity and overall quality of life. This study aimed to identify emerging patterns and prominent themes within FD and anxiety/depression research through bibliometric analysis to help explore new innovative avenues for investigating this type of FD.MethodsA comprehensive review of literature encompassing FD and anxiety/depression was conducted using the Science Citation Index Extension of the Web of Science Core Collection from 2003 to 2023. Information extracted comprised “Full Record and Cited References.” Bibliometric analysis of relevant publications, including country, institution, author, journal, citations, and keywords, was conducted using CiteSpace, VOSviewer, and Bibliometrix package in R and Excel.ResultsStudies related to FD and anxiety/depression have demonstrated an ascending trajectory since 2003. Our bibliometric analysis identified 338 studies published by 2023. NEUROGASTROENTEROLOGY AND MOTILITY emerged as the most prolific journal, while GASTROENTEROLOGY retained pre-eminence within the top 10 published journals. China emerged as the most prolific country, with two institutions within the top 10 in terms of volume of publications. The Mayo Clinic stood as the foremost institution in terms of publication volume, with the Chengdu University of Traditional Chinese Medicine exhibiting robust collaborative engagement. Eminent author influence was attributed to Talley NJ of Newcastle University, Australia. Clusters of extensively cited papers and prevalent keywords delineate the status and trend of FD and anxiety/depression research. This encompasses FD, anxiety, depression, sleep disorders, and functional gastrointestinal disorders. Furthermore, the timeline view map or trend-term analysis suggested that duodenal low-grade inflammation (“duodenal eosinophilia” and “mast cells”) might be a new concern associated with FD and anxiety/depression.ConclusionEmploying bibliometric analysis, this study revealed prevalent focal areas and new trends within FD and anxiety/depression research. These insights serve as valuable guidance for scholars seeking to delve into new research avenues.

Simultaneous Analysis of Thirteen Compounds in Yeokwisan Using High-Performance Liquid Chromatography–Photodiode Array Detection and Ultra-Performance Liquid Chromatography–Tandem Mass Spectrometry and Their Antioxidant Effects

“…Furthermore, for the YMC-Triart column (Figure S3C), isoliquiritigenin and glycyrrhizin were detected at the same retention time, and the resolution of poncirin was not as good as that achieved with the other columns. Although the resolution of 4-hydroxycinnamic acid on the SunFire TM column was slightly low, we were 5), ononin (6), baicalin (7), poncirin (8), wogonoside (9), baicalein (10), isoliquiritigenin (11), glycyrrhizin (12), and wogonin (13). The concentrations of each marker compound in the mixed standard solution were as follows: 4-hydroxycinnamic acid (10.00 µg/mL); ononin, baicalin, wogonoside, baicalein, isoliquiritigenin, and wogonin (20.00 µg/mL); narirutin and naringin (30.00 µg/mL); liquiritin (40.00 µg/mL); liquiritin apioside and poncirin (50.00 µg/mL); and glycyrrhizin (100.00 µg/mL).…”

“…formic acid (A), 0.1% (v/v) trifluoroacetic acid (B), and 1.0% (v/v) acetic acid (C). Liquiritin apioside (1), liquiritin (2), 4-hydroxycinnamic acid (3), narirutin (4), naringin (5), ononin (6), baicalin (7), poncirin (8), wogonoside (9), baicalein (10), isoliquiritigenin (11), glycyrrhizin (12), and wogonin (13); Figure S6: Comparison of HPLC-PDA chromatograms according to the flow rate for the 13 selected marker compounds: 0.8 mL/min (A) and 1.0 mL/min (B). Liquiritin apioside (1), liquiritin (2), 4-hydroxycinnamic acid (3), narirutin (4), naringin (5), ononin (6), baicalin (7), poncirin (8), wogonoside (9), baicalein (10), isoliquiritigenin (11), glycyrrhizin (12), and wogonin (13); Figure S7: HPLC chromatograms at LOD (A) and LOQ (B) concentrations.…”

“…Wavelength for quantification, linear range, regression equation, coefficient of determination (r 2 ), limit of detection (LOD), and limit of quantitation (LOQ) using HPLC-PDA simultaneous analysis of the 13 marker compounds in YWS. 5), ononin (6), baicalin (7), poncirin (8), wogonoside (9), baicalein (10), isoliquiritigenin (11), glycyrrhizin (12), and wogonin (13). 2 y: peak area of compounds; x: concentration (µg/mL) of compounds.…”

Deciphering the brain-gut axis: elucidating the link between cerebral cortex structures and functional gastrointestinal disorders via integrated Mendelian randomization

“…FD manifests as upper abdominal pain, a burning sensation, bloating, and early satiety, and involves increased gastrointestinal sensitivity ( Enck et al, 2017 ). Notably, patients frequently report emotional symptoms such as anxiety and depression ( Huang et al, 2023 ), which underscores the potential involvement of the gut-brain axis in FD.…”

“…The direct nursing costs of IBS in various nations range from 1.5 to 4.3 billion dollars ( Müller-Lissner and Pirk, 2002 ; Zhang et al, 2016 ; Goodoory et al, 2022 ), and the combined direct and indirect economic losses due to FD in the U.S. reach approximately 18 billion dollars annually ( Lacy et al, 2013 ). Moreover, the overlap of FD and IBS symptoms, along with their psychosomatic comorbidities, aggravates the economic burden significantly ( Huang et al, 2023 ; Kamp et al, 2023 ; Staudacher et al, 2023 ). Furthermore, these disorders also have a profound impact on quality of life, often leading to reduced work capacity and unnecessary surgeries due to misdiagnoses, thereby posing challenges to healthcare and society ( Drossman et al, 1993 ; Buono et al, 2017 ; Aziz et al, 2018 ; Black et al, 2020 ).…”