Deciphering the brain-gut axis: elucidating the link between cerebral cortex structures and functional gastrointestinal disorders via integrated Mendelian randomization
Zhiwei Xu,
Fenglan Ning,
Xuecheng Zhang
et al.
Abstract:BackgroundObservational studies have suggested associations between functional gastrointestinal disorders (FGIDs) and variations in the cerebral cortex. However, the causality of these relationships remains unclear, confounded by anxiety and depression. To clarify these causal relationships and explore the mediating roles of anxiety and depression, we applied univariate, multivariable, and mediation Mendelian randomization (MR) analyses.MethodWe utilized genome-wide association study (GWAS) summary data from t… Show more
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