Global Strategy for the Diagnosis, Management, and Prevention of Chronic Obstructive Pulmonary Disease

Pauwels, R.; Buist, A. Sonia; Calverley, P. M. A.; Jenkins, Christine; Hurd, Suzanne S.

doi:10.1164/ajrccm.163.5.2101039

Cited by 4,595 publications

(1,335 citation statements)

References 170 publications

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“…Distribution of patients according to Global Initiative for Chronic Obstructive Lung Disease (GOLD) staging category (Pauwels, Buist, Calverley, Jenkins, & Hurd, 2001) is as follows: mild COPD: forced expiratory volume in 1‐second (FEV1)/forced vital capacity (FVC) %<70%, FEV1 > 80% predicted, n = 1; moderate COPD: FEV1/FVC<70%, 30%<FEV1 < 80% predicted, n = 10; severe COPD: FEV1/FVC<70%, FEV1 < 30% predicted, n = 7. At the time of data collection, patients were in clinically stable condition.…”

Section: Methodsmentioning

confidence: 99%

Vasogenic cerebral edema associated with the disability in activities of daily living in patients with chronic obstructive pulmonary disease

et al. 2018

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IntroductionThe aim of this study was to explore whether patients with chronic obstructive pulmonary disease (COPD) develop vasogenic cerebral edema, and whether this edema contributes to the COPD‐related disability.MethodsEighteen stable patients with COPD and 17 matched healthy volunteers were enrolled. Apparent diffusion coefficient (ADC) values were calculated by voxel‐based analysis using DTI‐Studio software based on diffusion tensor imaging. COPD‐related disability was calculated using activities of daily living (ADL) scale.ResultsIn patients with COPD, ADC increased in the white matter fiber tracts including the bilateral anterior cingulum and posterior corpus callosum and in the white matter fibers connecting the bilateral insular cortices, sub‐lobar cortices, and pars triangularis cortices and the left rectus and olfactory gyrus. However, after further controlling for cigarette smoking, the difference in ADC values in the posterior corpus callosum between groups disappeared. Patients with COPD had significantly higher scores in ADL than that in controls. Moreover, ADL scores were positively correlated with the increased regional ADC values.ConclusionVasogenic cerebral edema occurs in patients with COPD. Cigarette smoking may be a risk factor for COPD‐related vasogenic edema. Vasogenic cerebral edema may be related to the COPD‐related ADL impairment.

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Section: Methodsmentioning

confidence: 99%

Vasogenic cerebral edema associated with the disability in activities of daily living in patients with chronic obstructive pulmonary disease

et al. 2018

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“…Entsprechend dem Ergebnis der Lungenfunktionsprüfung wird die COPD nach den GOLD-Kriterien in 4 Schweregrade (0-III) eingeteilt (13). Die Bestimmung des Peakflows (PEF) hat nur eine untergeordnete diagnostische Bedeutung (16).…”

Section: Diagnostikunclassified

“…Eine fehlende Reversibilität (Anstieg des FEV 1 < 200ml und < 15% vom Ausgangswert) erhärtet die Diagnose COPD und macht ein Asthma bronchiale unwahrscheinlich. Ein FEV 1 /FVC-Quotient von < 70% wird als Frühzeichen einer beginnenden Atemwegsobstruktion bei denjenigen Patienten angesehen, deren FEV 1 > 80% des Solls gemessen wurde (13).…”

Section: Diagnostikunclassified

“…Ein respiratorisches Versagen wird bei folgenden Werten angenommen: pO 2 < 8,0 kPa (60 mmHg) oder pCO 2 > 6,0 kPa (45 mmHg; bezogen auf Meereshöhe). Die Bestimmung des Serum-Alpha-1-Antitrypsin-Spiegels ist bei jungen Patienten (< 45 Jahre) mit einer COPD und/oder einem Lungenemphysem indiziert (13).…”

Section: Diagnostikunclassified

“…Diese Definition wurde in der neuesten Empfehlung zur Diagnostik und Therapie der COPD von der GOLD-Initiative (Global Initiative for Chronic Obstructive Lung Disease) überarbeitet (13 …”

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