Global Perspective of the Vitamin D Status of African-Caribbean Populations: A Systematic Review and Meta-analysis

Vearing, Rebecca; Hart, Kathryn; Darling, A. L.; Probst, Yasmine; Olayinka, A.S.; Mendis, Jeewaka; Ribeiro, Helena; Thakur, Siddhartha; Mendes, Marcela Moraes; Charlton, Karen E; Lanham-New, Susan

doi:10.1038/s41430-021-00980-9

Cited by 15 publications

(12 citation statements)

References 44 publications

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“…Vitamin D intake was well below the RNI of 10 µg/day for not only the AC group, but all ethnicities analysed in this paper, which is consistent with other research in the UK showing suboptimal intakes in AC [26,27,38] and SA [14,43,45] populations and confirming that diet alone is currently an inadequate source of vitamin D in the UK.…”

Section: Discussionsupporting

confidence: 91%

“…Our findings support the results of a recent meta-analysis, which found vitamin D insufficiency across four small (total n = 995) observational studies [23][24][25]37] of AC populations living at high latitudes [38]. In the current analysis, the AC group had a lower 25(OH)D concentration than the WE group, who were borderline 25(OH)D sufficient on average.…”

Section: Discussionsupporting

confidence: 90%

“…The AC diaspora who migrated away from the equator to a much higher latitude have become at high risk for vitamin D deficiency. It is well known that there is an inverse association between distance from the equator and 25(OH)D concentration [38]. As shown in our results for 25(OH)D in AC and AF, median 25(OH)D concentration was insufficient at all UK sites.…”

Section: Discussionsupporting

confidence: 71%

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Vitamin D Status of the British African-Caribbean Residents: Analysis of the UK Biobank Cohort

et al. 2021

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The vitamin D status of the United Kingdom (UK) African-Caribbean (AC) population remains under-researched, despite an increased risk of vitamin D deficiency due to darker skin phenotypes and living at a high latitude. This cross-sectional study explored the vitamin D status and intake of AC individuals (n = 4046 with a valid serum 25(OH)D measurement) from the UK Biobank Cohort, aged ≥40 years at baseline (2006–2010). Over one third of the population were deficient (<25 nmol/L), 41.1% were insufficient (25–50 nmol/L) and 15.9% were sufficient (>50 nmol/L). Median (IQR) 25(OH)D was 30.0 (20.9) nmol/L. Logistic regression showed that brown/black skin phenotype, winter blood draw, not consuming oily fish and not using vitamin D supplements predicted increased odds of vitamin D deficiency, whilst older age and a summer or autumn blood draw were significantly associated with reduced odds of vitamin D deficiency. Vitamin D deficiency and insufficiency were prevalent in this AC population and is of considerable concern given the individual and societal implications of increased morbidity. Public health messaging for this group should focus on year-round vitamin D supplementation and increasing intakes of culturally appropriate vitamin D-rich foods. These data also support the urgent requirement for a revised vitamin D RNI for ethnic groups.

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Section: Discussionsupporting

confidence: 91%

Section: Discussionsupporting

confidence: 90%

Section: Discussionsupporting

confidence: 71%

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Vitamin D Status of the British African-Caribbean Residents: Analysis of the UK Biobank Cohort

et al. 2021

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“…Vearing и соавт. [28]. Статистически значимые различия были выявлены между северной и южной географическими зонами как при анализе концентрации 25(OH)D в сыворотке крови младших школьников, так и при оценке относительных показателей распространенности дефицита, недостаточности и оптимального уровня витамина D. Центральная территория статистически значимо отличалась от северной только при сопоставлении концентрации 25(OH)D и не имела существенных различий при сравнении относительных величин обеспеченности витамином D с 48° и 52° с.ш., что может свидетельствовать об определенном диапазоне географических широт, играющих роль в различии статуса витамина D (в нашем случае значимым был интервал, равный 4° с.ш).…”

Section: интерпретация результатов исследованияunclassified

Vitamin D Supplementation of 7–8 Years Old Children from Different Geographical Areas (48–52° North Latitude): Cross Sectional Study

Senkevich

Chebargina

Golubkina

2022

Vopr. sovr. pediatr.

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Background. The prevalence of vitamin D deficiency in children by their geographic latitude of residence requires follow-up study. This is crucial for implementation of preventive measures that can reduce the risk of developing pathological conditions associated with vitamin D deficiency.Objective. The aim of the study is to study the vitamin D supplementation of 7–8 years old children living in different geographical latitudes of one subject of Russian Federation.Methods. The study included relatively healthy children living in three geographical areas (northern — 52°, central — 50°, southern — 48°) of one region (Khabarovsk Krai). Vitamin D supplementation was evaluated by 25(OH)D serum concentration via enzyme-linked immunosorbent assay. Vitamin D insufficiency was diagnosed at 25(OH)D concentration of 21–30 ng/ml, deficiency — 10–20 ng/ml, severe deficiency — < 10 ng/ml; optimal 25(OH)D concentration was considered as 30–100 ng/ml.Results. The increase in prevalence of vitamin D deficiency and insufficiency has been revealed with gradual increase from southern (57%) to central (73%) and northern (83%) geographic areas in 7–8 years old children living in the same region. The prevalence of vitamin D deficiency and insufficiency (25(OH)D ≤ 30 ng/mL) among children living in the northern geographic area was greater by 3.8-fold (95% confidence interval 1.2–12.7) then among peers living in the southern areas.Conclusion. One factor affecting 25(OH)D serum concentration in children of this region is the insolation level determined by the geographical latitude of residence. The 4°N difference is significant in determining vitamin D status in residents of relatively high latitudes. Further studies of factors associated with 25(OH)D concentration in children living in different latitudes are required (insolation level, number of sunny days per year, food and household characteristics in families).

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“…Furthermore, a low adherence to constant daily supplementation in infants and toddlers, even in culturally and economically diverse settings, has been frequently described [ 22 , 23 , 24 , 25 ]. For this reason, in addition to the lack of evidence about a substantial difference between a daily or a weekly/monthly administration or possible adverse effects, we decided to analyze different VD supplementation methods, comparing the VD sufficiency rates that followed the different interventions, while considering both safety and efficacy outcomes.…”

Section: Introductionmentioning

confidence: 99%

Different Vitamin D Supplementation Strategies in the First Years of Life: A Systematic Review

et al. 2022

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Vitamin D (VD) is an essential micronutrient with multiple functions for human growth, and adequate intake should be guaranteed throughout life. However, VD insufficiency is observed in infants all over the world. Low VD concentration in the breast milk of non-supplemented mothers and low compliance to VD daily supplementation are the main causes of VD insufficiency, especially in the long term. Furthermore, VD supplementation dosages are still debated and differ by country. We conducted a systematic review to compare the most recent evidence on different postnatal VD supplementation strategies, determining whether supplementation given to the mother is as effective as that administered directly to the child, and whether different dosages and administration schedules differ significantly in terms of efficacy and safety. We identified 18 randomized controlled trials (RCTs) addressing the role of infant (n = 961), maternal (n = 652) or combined infant and maternal VD supplementation (n = 260 pairs). In all studies, similar outcomes emerged in terms of efficacy and safety. According to our findings, alternative approaches of VD supplementation may be adopted, especially in cases where the adherence to daily supplementation strategies is poor. This review shows that different dosages and supplementation strategies result in similar VD sufficiency rates. Therefore, international guidelines may be revised in the future to offer multiple and different options of supplementation for specific settings and ages.

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Global Perspective of the Vitamin D Status of African-Caribbean Populations: A Systematic Review and Meta-analysis

Cited by 15 publications

References 44 publications

Vitamin D Status of the British African-Caribbean Residents: Analysis of the UK Biobank Cohort

Vitamin D Status of the British African-Caribbean Residents: Analysis of the UK Biobank Cohort

Vitamin D Supplementation of 7–8 Years Old Children from Different Geographical Areas (48–52° North Latitude): Cross Sectional Study

Different Vitamin D Supplementation Strategies in the First Years of Life: A Systematic Review

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