Global perceptions of food allergy thresholds in 16 countries

Marchisotto, Mary Jane; Harada, Laurie; Blumenstock, Jesse; Bilaver, Lucy; Waserman, Susan; Sicherer, Scott H.; Boloh, Yanne; Regent, Lynne; Said, Maria; Schnadt, Sabine; Allen, Katrina J.; Muraro, Antonella; Taylor, Steve L.; Gupta, Ruchi S.

doi:10.1111/all.12933

Cited by 20 publications

(14 citation statements)

References 20 publications

(20 reference statements)

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“…Parents and allergic individuals will sometimes ignore precautionary statements (8)(9)(10)43) under the assumption that the risk of allergen contamination in these foods is low and phrasing-dependent. We examined the reality of this emergent risk stratification for commercial food products including breads, flours, desserts, snacks and other foods.…”

Section: Discussionmentioning

confidence: 99%

Addressing Complex Matrix Interference Improves Multiplex Food Allergen Detection by Targeted LC–MS/MS

2019

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The frequent use of precautionary food allergen labeling statements such as "may contain" poses challenges to allergic individuals who rely on such labeling to determine whether a food is safe to consume. We developed a multiplexed liquid chromatography-mass spectrometry assay targeting 14 common allergens in order to survey how frequently these precautionary statements indicate allergen contamination and to assess whether variations in precautionary phrasing affect the likelihood of allergen contamination. A survey of 84 foods revealed how scheduled multiple reaction monitoring (MRM) transition interference derived from complex and heterogeneous sample matrices hinders sensitive analyte detection. As a solution, we developed MAtrix-Dependent Interference Correction (MADIC), an approach to sensitively detect trace peptide quantities through interference identification and stringent peptide quality control criteria. Applying this method, we find frequent contamination of soy in breads and corn flour, and observe additional instances of food contamination with tree nuts, wheat, milk, and egg. In some of these cases, the food had no precautionary labeling for the offending allergen. We also find that only 10% of warning labels are indicative of contamination, and that products with "same facility" precautionary labeling are not necessarily less likely to contain trace amounts of allergens than products labeled "may contain.".

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Section: Discussionmentioning

confidence: 99%

Addressing Complex Matrix Interference Improves Multiplex Food Allergen Detection by Targeted LC–MS/MS

2019

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“…In this study, the author examined the attitudes of consumers regarding food labelling in 16 countries. It demonstrated that consumers may develop their own risk assessment based on PAL labels and appear to trust PAL labels to provide an estimate of reaction risk . This trust in PAL may come without the consumer's knowledge that PAL is voluntary, unregulated and not endorsed by any government agency.…”

Section: Discussionmentioning

confidence: 99%

The practice and perception of precautionary allergen labelling by the Australasian food manufacturing industry

Zurzolo

Peters

Koplin

et al. 2017

Clin Experimental Allergy

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“…To limit the risk of allergy, the industry widely uses precautionary labeling (i.e., "may contain…"), but food recalls due to unlabeled allergens are constantly increasing (4). The lack of correlation between precautionary labeling and the presence of allergens frequently leads allergenic people to ignore the labeling (5). In addition, the absence of regulatory thresholds for allergens does not help food producers establish trustworthy labeling.…”

Section: Food Laboratories Have Developed Methods For Testing Allergementioning

confidence: 99%

Highlight on Bottlenecks in Food Allergen Analysis: Detection and Quantification by Mass Spectrometry

Planque

Arnould

Renard

et al. 2017

Journal of AOAC INTERNATIONAL

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Food laboratories have developed methods for testing allergens in foods. The efficiency of qualitative and quantitative methods is of prime importance in protecting allergic populations. Unfortunately, food laboratories encounter barriers to developing efficient methods. Bottlenecks include the lack of regulatory thresholds, delays in the emergence of reference materials and guidelines, and the need to detect processed allergens. In this study, ultra-HPLC coupled to tandem MS was used to illustrate difficulties encountered in determining method performances. We measured the major influences of both processing and matrix effects on the detection of egg, milk, soy, and peanut allergens in foodstuffs. The main goals of this work were to identify difficulties that food laboratories still encounter in detecting and quantifying allergens and to sensitize researchers to them.

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Global perceptions of food allergy thresholds in 16 countries

Cited by 20 publications

References 20 publications

Addressing Complex Matrix Interference Improves Multiplex Food Allergen Detection by Targeted LC–MS/MS

Addressing Complex Matrix Interference Improves Multiplex Food Allergen Detection by Targeted LC–MS/MS

The practice and perception of precautionary allergen labelling by the Australasian food manufacturing industry

Highlight on Bottlenecks in Food Allergen Analysis: Detection and Quantification by Mass Spectrometry

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