Global pattern and trends of colorectal cancer survival: a systematic review of population-based registration data

Jiang, Yimei; Yuan, Hang; Li, Zhuoying; Shen, Qishun; Tuo, Jia‐Yi; Bi, Jing-Hao; Li, Honglan; Xiang, Yong‐Bing

doi:10.20892/j.issn.2095-3941.2020.0634

Cited by 39 publications

(32 citation statements)

References 70 publications

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“…Executive Introduction G LOBALLY, COLORECTAL CANCER is the third most common cancer and second most common cause of cancer related deaths. 1 The highest rates of colorectal cancer are thought to be in the Europe, North America, Australia and lower rates in Africa and Asia. 2 According to recent 2020 GLOBOCAN database, CRC is the fourth most common cancer in Africa and fifth most common cause of cancer related mortality.…”

Section: Endo 2022 Highlights Gallerymentioning

confidence: 99%

WEO newsletter

2022

Digestive Endoscopy

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A FTER THE CULMINATION of more than 2 years of intensive planning and the direction of Fabian Emura and Hisao Tajiri, ENDO 2022 has come to a successful end. To achieve this milestone event WEO and the Japan Gastroenterological Endoscopy Society (JGES) set up a historic collaboration. Thus, the third World Congress of GI Endoscopy took place jointly with the 103rd JGES Congress under the Presidency of Haruhiko Ogata.The hybrid ENDO 2022 event took place from May 13 to 15, 2022. Although it was not possible for all international faculty and attendees to meet face-to-face in Kyoto, ENDO 2022 and the 103rd JGES Congress welcomed a total of 9940 delegates, joining virtually from over 75 countries or on-site in Japan at the Kyoto Convention Center. And ENDO 2022 will be available on-demand until June 30 for all registered participants.

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Section: Endo 2022 Highlights Gallerymentioning

confidence: 99%

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2022

Digestive Endoscopy

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“… 2 , 3 Statistics show that the tumor frequently recurs and metastasizes, spreading especially to the liver, lung, bone, and ovaries, and the five-year survival rate for such patients is approximately 10%. 4 , 5 Treatment methods for CRC include chemotherapy, surgery, radiotherapy, and molecular-targeted therapy. 6 , 7 Molecular-targeted therapy for CRC has become a hot topic.…”

Section: Introductionmentioning

confidence: 99%

An Analysis Regarding the Association Between Connexins and Colorectal Cancer (CRC) Tumor Microenvironment

Liu¹,

Han²,

Li³

et al. 2022

JIR

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Background Gap junctions, as one of the major ways to maintain social connections between cells, are now considered as one of the potential regulators of tumor metastasis. However, to date, studies on the relationship between gap junctions and colorectal cancer (CRC) are limited. Methods We synthesized connexins-coding gene expression data from public Gene Expression Omnibus (GEO) and The Cancer Genome Atlas (TCGA) databases. Bioinformatics analysis was performed using R software and several database resources such as MEXPRESS database, Gene Set Cancer Analysis (GSCA) database, Human Protein Atlas (HPA) database, Tumor Immune Single Cell Hub (TISCH) database, Search Tool for Retrieval of Gene Interaction Relationships (STRING), and Cytoscape software, etc., to investigate the biological mechanisms that may be involved in connexins. Immunofluorescence and immunohistochemical staining were used to validate the expression and localization of GJA4. Results We found that CRC patients can be divided into two connexin clusters and that patients in cluster C1 had shorter survival than in cluster C2. The infiltration of M1 macrophages and NK cells was lower in cluster C1, while the levels of M2 macrophages and immune checkpoints were higher, indicating an immunosuppressed state in cluster C1. In addition, the epithelial–mesenchymal transition (EMT) phenotype was significantly activated in cluster C1. We observed that GJA4 was up-regulated in colorectal cancer tissues, which was related to poor prognosis. It was mainly expressed in fibroblasts, but the expression levels in normal intestinal epithelial cells were low. Finally, we found that GJA4 was associated with M2 macrophages and may be a potential immunosuppressive factor. Conclusion We found that there is a significant correlation between abnormal connexins expression and patients’ prognosis, and connexins play an important role in stromal-tumor interactions. Connexins, especially GJA4, can help enhance our understanding of tumor microenvironment (TME) and may guide more effective immunotherapeutic strategies.

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“…Colorectal cancer (CRC), a common gastrointestinal cancer, is ranked as one of the three most common cancers worldwide, with 1,147,950 new cases and 53,200 deaths estimated in 2020 ( 1 ). The life expectancy of patients with CRC has considerably improved due to early diagnosis and treatment ( 2 , 3 ). Therebefore, increasing mortality burden is not derived from cancer but from non-cancer causes.…”

Section: Introductionmentioning

confidence: 99%

Cardiovascular Outcomes in the Patients With Colorectal Cancer: A Multi-Registry-Based Cohort Study of 197,699 Cases in the Real World

Zhang

Wang

Zhang

et al. 2022

Front. Cardiovasc. Med.

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PurposeWe aimed to investigate the mortality patterns and quantitatively assess the risks of cardiovascular death (CVD) in patients with colorectal cancer (CRC). We also established a competing-risk model to predict the probability of CVD for patients with CRC.Patients and MethodsPatients with CRC who diagnosed between 2007 and 2015 in the Surveillance, Epidemiology, and End Results (SEER) database were included in the present study. The cumulative incidence function (CIF) was used for CVD and other causes of death, and Gray’s test was used to determine the subgroup difference in CIF. The Fine-Gray proportional subdistribution hazards model was used for identifying independent risk factors for CVD. A novel competing-risk model was established to evaluate the probability of CVD for patients with CRC. The performance of the nomogram was measured by concordance index (C-index), calibration curve, decision curve analysis (DCA), and risk stratification.ResultsAfter a median follow-up of 37.00 months, 79,455 deaths occurred, of whom 56,185 (70.71%) succumbed to CRC and 23,270 (29.29%) patients died due to non-CRC, among which CVD accounted for 9,702 (41.69%), being the major cause of non-cancer deaths. The 1-, 3-, and 5-year cumulative rates for CVD were 12.20, 24.25, and 30.51%, respectively. In multivariate analysis, age, race, marital status, tumor size, tumor stage, advanced stage, surgery, and chemotherapy were independent risk factors of CVD among patients with CRC. The nomogram was well calibrated and had good discriminative ability, with a c-index of 0.719 (95% CI, 0.738–0.742) in the training cohort and 0.719 (95% CI, 0.622–0.668) in the validation cohort. DCA demonstrated that nomogram produced more benefit within wide ranges of threshold probabilities for 1-, 3-, and 5-year CVD, respectively.ConclusionThis study was the first to analyze the CIF and risk factors for CVD among CRC based on a competing-risk model. We have also built the first 1-, 3-, and 5-year competing nomogram for predicting CVD. This nomogram had excellent performance and could help clinicians to provide individualized management in clinical practice.

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Global pattern and trends of colorectal cancer survival: a systematic review of population-based registration data

Cited by 39 publications

References 70 publications

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An Analysis Regarding the Association Between Connexins and Colorectal Cancer (CRC) Tumor Microenvironment

Cardiovascular Outcomes in the Patients With Colorectal Cancer: A Multi-Registry-Based Cohort Study of 197,699 Cases in the Real World

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