Global Longitudinal Strain Predicts Survival and Left Ventricular Function After Mitral Valve Surgery: A Meta-analysis

Canessa, Martín; Thamman, Ritu; Américo, Carlos; Soca, Gerardo; Dayan, Víctor

doi:10.1053/j.semtcvs.2020.09.024

Cited by 15 publications

(4 citation statements)

References 25 publications

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“…GLS mainly mirrors the contractility of subendocardial longitudinal fibers that often display impaired function in the early phase of myocardial injury, when LV ejection fraction (LVEF) can still be maintained 7 . LV GLS provides incremental value beyond LVEF in the prediction of adverse events in patients with chronic heart failure 8,9 , ischemic heart disease 10 , myocarditis 11 , valvular heart disease [12][13][14][15] , and several other cardiac diseases 4,[16][17][18] .…”

Section: Introductionmentioning

confidence: 99%

Reproducibility of 4D cardiac computed tomography feature tracking myocardial strain and comparison against speckle-tracking echocardiography in patients with severe aortic stenosis

Bernhard

Grogg

Zurkirchen

et al. 2022

Journal of Cardiovascular Computed Tomography

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Section: Introductionmentioning

confidence: 99%

Reproducibility of 4D cardiac computed tomography feature tracking myocardial strain and comparison against speckle-tracking echocardiography in patients with severe aortic stenosis

Bernhard

Grogg

Zurkirchen

et al. 2022

Journal of Cardiovascular Computed Tomography

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“…While in the current study regression analysis for prediction of LVEF <50% after mitral valve surgery found the LVESD ≥40 mm and LVGLS < −19% were the better predictors with OR = 6.6 (95%CI 1.97–23.64) and 21.8 (95%CI 6.61–82.41) respectively. A meta-analysis from 8 studies with severe MR and preserved left ventricular ejection fraction has shown that reduced LV GLS before surgery was a predictor of worse post-operative survival and LVEF with HR = 1.13, 95% CI 1.02–1.26 [ 16 ]. While the study published by Tomasz et al [ 8 ] reported similar values of LVESD ≥40 mm and LVGLS > −19.9% were the better predictors of LVEF <50% after surgery with OR = 6.71 (1.91–23.52) and 23.16 (95%CI 6.53–82.10) respectively.…”

Section: Discussionmentioning

confidence: 75%

Role of speckle tracking echocardiography to predict LV dysfunction post mitral valve replacement surgery for severe mitral regurgitation

Shanishwara¹,

Vyas²,

Joshi³

et al. 2022

Journal of the Saudi Heart Association

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Background Despite improvement in the surgical procedure and strictly following the guidelines for mitral valve replacement (MVR), left ventricular dysfunction still occurs. Novel echocardiographic indices can predict development of LV (left ventricle) dysfunction post MVR. LV-GLS (global longitudinal strain) derived from speckle tracking echocardiography, has been proposed as a novel measure to better depict latent LV dysfunction. Methods A total of 100 patients with severe MR (mitral regurgitation) planned for MVR were included. Speckle tracking echocardiography was performed at baseline and at follow up post MVR. ROC (Receiver operating characteristics) curve was plotted to derive the cutoff value of LV-GLS for prediction of LV dysfunction post MVR. Univariate and multi variate regression was analyzed to predict the independent predictors of LV dysfunction after MVR. Results LV-GLS was decreased from baseline data (−19.9 vs. −17.7) in patients with LVEF <50% after MVR compared to patients with LVEF≥ 50%. Baseline value of LVESD (35.36 mm vs. 28.23 mm) and LVEDD (49.33 mm vs. 45.10 mm) were significantly higher in patients with LVEF<50% compared to LVEF ≥50% at 3 months follow up. A cutoff value of GLS −19% with sensitivity of 80.3% and specificity of 75.7% was associated in patients with LV dysfunction after MVR. In multivariate regression model GLS < −19% (OR = 21.8, CI:6.61–82.4, P=<0.001) was an independent predictor of LV dysfunction post MVR. Conclusion A GLS value of less than −19% was demonstrated as an independent predictor of short term LV dysfunction after mitral valve surgery, LVESD ≥40 mm was also verified additional parameter to predict the LV dysfunction post MVR.

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“…To conclude, a recent meta-analysis involving 2358 patients (from 8 studies) with severe MR and preserved LVEF highlighted that a reduced LV GLS before surgery was a predictor of worse postoperative survival (HR = 1.13, 95%CI: 1.02–1.26) and LVEF [ 29 ].…”

Section: Left Ventricular Global Longitudinal Strain In Mitral Regurg...mentioning

confidence: 99%

Speckle tracking echocardiography in primary mitral regurgitation: should we reconsider the time for intervention?

et al. 2021

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Thanks to the improvement in mitral regurgitation (MR) diagnostic and therapeutic management, with the introduction of minimally invasive techniques which have considerably reduced the individual surgical risk, the optimization of the timing for MR “open” or percutaneous surgical treatment has become a main concern which has highly raised scientific interest. In fact, the current indications for intervention in MR, especially in asymptomatic patients, rely on echocardiographic criteria with high severity cut-offs that are fulfilled only when not only mitral valve apparatus but also the cardiac chambers’ structure and function are severely impaired, which results in poor benefits for post-operative clinical outcome. This led to the need of new indices to redefine the optimal surgical timing in these patients. Speckle tracking echocardiography provides early markers of cardiac dysfunction due to subtle myocardial impairment; therefore, it could offer pivotal information in this setting. In fact, left ventricular and left atrial strains have already shown evidence about their usefulness in recognizing MR impact not only on symptoms and quality of life but also on cardiovascular events and new-onset atrial fibrillation in these patients. Moreover, right ventricular strain could be used to identify those patients with advanced cardiac damage and different grades of right ventricular dysfunction, which entails higher risks for cardiac surgery that could overweigh surgical benefits. This review aims to describe the importance of reconsidering the timing of intervention in MR and to analyze the potential additive value of speckle tracking echocardiography in this clinical setting.

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Global Longitudinal Strain Predicts Survival and Left Ventricular Function After Mitral Valve Surgery: A Meta-analysis

Cited by 15 publications

References 25 publications

Reproducibility of 4D cardiac computed tomography feature tracking myocardial strain and comparison against speckle-tracking echocardiography in patients with severe aortic stenosis

Reproducibility of 4D cardiac computed tomography feature tracking myocardial strain and comparison against speckle-tracking echocardiography in patients with severe aortic stenosis

Role of speckle tracking echocardiography to predict LV dysfunction post mitral valve replacement surgery for severe mitral regurgitation

Speckle tracking echocardiography in primary mitral regurgitation: should we reconsider the time for intervention?

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