Reproducibility of 4D cardiac computed tomography feature tracking myocardial strain and comparison against speckle-tracking echocardiography in patients with severe aortic stenosis

Abstract

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Left Atrial Cardiomyopathy – A Challenging Diagnosis

“…Furthermore, it has recently been demonstrated that CT can also be applied for strain measurements. LA strain measured by CT correlates strongly with strain measurements derived from speckle-tracking echocardiography (94)(95)(96).…”

Predictive value of cardiac magnetic resonance right ventricular longitudinal strain in patients with suspected myocarditis

“…CMR does not only allow to accurately assess LV dimension/function and tissue characteristics, but also proved to inherit important information from RV function. Echocardiography represents a reproducible method to derive RV GLS and RVEF but may be challenging in patients with impaired echo window [ 38 ], and RV GLS values only moderately agree to those of CMR, underlining the need for separate cut-off values [ 24 , 39 ]. CMR-based evaluation of the updated Lake-Louise Criteria [ 40 ] and endomyocardial biopsy are currently the cornerstones in the diagnosis of myocarditis, also incorporating powerful outcome prognosticators from LV function and tissue characteristics [ 9 , 11 – 13 , 19 , 41 ].…”

Advancements in CT Tissue Characterization: Myocardial Insights in Aortic Stenosis and Amyloidosis

“…In fact, CT, when scanned throughout a full cardiac cycle (ie, 4-dimensional CT), allows assessing cardiac volume and function, as well as myocardial strain calculations, which correlates well with echocardiography. 15 The potential of 4-dimensional CT in tailoring risks and predicting outcomes, such as reverse remodeling and mortality following a transcatheter aortic valve replacement, has been assessed in a study by our group including 608 patients. CT-based LV mass index and left ventricular ejection fraction could predict 12-month reverse remodeling, whereas CT-based LVEF and left atrial ejection fraction emerged as independent predictors of survival.…”

“…It, therefore, seems that routine 4-dimensional CT in severe AS can provide high diagnostic performance in the detection of concomitant ATTR-CM. 18 However, these measurements were only evaluated in a global fashion, and combining the approaches of regional function with ECV CT would definitely both, further enhance our understanding of the disease mechanism, and refine risk stratification.…”