Global longitudinal strain by two-dimensional speckle tracking imaging predicts exercise capacity in patients with chronic heart failure

Kou, Seisyou; Suzuki, Kazuhiro; Akashi, Yoshihiro; Mizukoshi, Kei; Takai, Manabu; Izumo, Masaki; Sugiyama, Takashi; Hayashi, Akio; Ohtaki, Eiji; Osada, Naohiko; Omiya, Kazuto; Nobuoka, Sachihiko; Miyake, Fumihiko

doi:10.1007/s12574-010-0076-3

Cited by 5 publications

(3 citation statements)

References 26 publications

(24 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The LVEF is not correlated with functional capacity [ 27 ]. Most evidence on the association between exercise tolerance and cardiac strain has predominantly focused on patients with HF [ 28 ]. However, this relationship has not been investigated and demonstrated in patients with IHD.…”

Section: Discussionmentioning

confidence: 99%

Diagnostic Accuracy of Global Longitudinal Strain for Detecting Exercise Intolerance in Patients with Ischemic Heart Disease

Zhang

Liu

Jiang

et al. 2022

JCDD

View full text Add to dashboard Cite

Objective: Global longitudinal strain (GLS) is a sensitive and reproducible predictive factor in patients with ischemic heart disease (IHD), although its correlation with exercise tolerance is unknown. We aimed to identify the correlation between global longitudinal strain (GLS) and cardiopulmonary exercise testing (CPX) parameters and assess the prognostic implications and accuracy of GLS in predicting exercise intolerance in populations with ischemic heart disease (IHD) using CPET criteria. Methods: Prospectively, 108 patients with IHD underwent CPX and 2D speckle-tracking echocardiography. Correlation between GLS and multiple CPX variables was assessed using Spearman’s correlation analysis and univariate regression analysis. A receiver operating characteristic (ROC) curve analysis was performed on GLS to detect exercise intolerance. Results: GLS was correlated with peak oxygen uptake (peak VO2; r = −0.438, p = 0.000), %PPeak VO2 (−0.369, p = 0.000), peak metabolic equivalents (METs@peak; r = −0.438, p < 0.01), and the minute ventilation–carbon dioxide production (VE/VCO2) slope (r = 0.257, p < 0.01). Weak-to-moderate correlations were also identified for the respiratory exchange rate at the anaerobic threshold (RER@AT), end-tidal carbon dioxide at the anaerobic threshold (PETCO2@AT), oxygen consumption at the anaerobic threshold (VO2@AT), carbon dioxide production at the anaerobic threshold (VCO2@AT), and metabolic equivalents at the anaerobic threshold (METs@AT; p < 0.01). On multivariate analysis, the results showed that age, the BMI, and GLS are independent predictors for reduced exercise capacity in patients with IHD (p < 0.01). The area under the ROC curve value of GLS for identifying patients with a peak VO2 of <14 mL/kg/min was 0.73 (p = 0.000). Conclusion: As a sensitive echocardiographic assessment of patients with ischemic heart disease, global longitudinal strain is an independent predictor of reduced exercise capacity and has a sensitivity of 74.2% and a specificity of 66.7% to detect exercise intolerance.

show abstract

Section: Discussionmentioning

confidence: 99%

Diagnostic Accuracy of Global Longitudinal Strain for Detecting Exercise Intolerance in Patients with Ischemic Heart Disease

Zhang

Liu

Jiang

et al. 2022

JCDD

View full text Add to dashboard Cite

show abstract

“…However, additional ultrasound‐based cardiac and endothelial function measures, such as speckle tracking echocardiography and brachial artery flow‐mediated dilation (FMD), have been extensively studied in research settings. These additional parameters may provide enhanced prognosis and monitoring information about the cardiac and vascular function (Awadalla et al, 2017; Kou et al, 2011; Thijssen et al, 2011) and facilitate the detection of more subtle changes in cardiovascular function after interventions such as exercise‐based cardiac rehabilitation (Awadalla et al, 2017; Kou et al, 2011). Brachial artery FMD has proven effective as a non‐invasive and independent predictor of cardiac events (Green et al, 2011; Al et al, 2000) and a surrogate for coronary artery function (Anderson et al, 1995; Takase et al, 1998).…”

Section: Introductionmentioning

confidence: 99%

“…We investigated the effect of TRAD compared to STAIR training on cardiovascular function using both clinical and additional measures. Informed by recent evidence regarding the effect of moderate-intensity exercise training compared to a non-exercise control (Kou et al, 2011), we hypothesized that brachial artery FMD, left ventricular twist, and myocardial performance index would improve after HIIT to the same extent as TRAD. Additionally, in alignment with the previously observed time course for changes in clinical measures of cardiac function (Ehsani et al, 1978;Giannuzzi et al, 2003;Haykowsky et al, 2007), we hypothesized there would be no change in global longitudinal strain, ejection fraction or other clinical indices of cardiac function in both TRAD and HIIT.…”

Section: Introductionmentioning

confidence: 99%

Cardiovascular responses to high‐intensity stair climbing in individuals with coronary artery disease

Valentino

Dunford

Dubberley

et al. 2022

Physiological Reports

View full text Add to dashboard Cite

Exercise‐based cardiac rehabilitation leads to improvements in cardiovascular function in individuals with coronary artery disease. The cardiac effects of coronary artery disease (CAD) can be quantified using clinical echocardiographic measures, such as ejection fraction (EF). Measures of cardiovascular function typically only used in research settings can provide additional information and maybe more sensitive indices to assess changes after exercise‐based cardiac rehabilitation. These additional measures include endothelial function (measured by flow‐mediated dilation), left ventricular twist, myocardial performance index, and global longitudinal strain. To investigate the cardiovascular response to 12 week of either traditional moderate‐intensity (TRAD) or stair climbing‐based high‐intensity interval (STAIR) exercise‐based cardiac rehabilitation using both clinical and additional measures of cardiovascular function in individuals with CAD. Measurements were made at baseline (BL) and after supervised (4wk) and unsupervised (12 week) of training. This study was registered as a clinical trial at clinicaltrials.gov (NCT03235674). Participants were randomized into either TRAD (n = 9, 8M/1F) and STAIR (n = 9, 8M/1F). There was a training‐associated increase in one component of left ventricular twist: Cardiac apical rotation (TRAD: BL: 5.6 ± 3.3º, 4 week: 8.0 ± 3.9º, 12 week: 6.2 ± 5.1º and STAIR: BL: 5.1 ± 3.6º, 4 week: 7.4 ± 3.9º, 12 week: 7.8 ± 2.8º, p (time) = 0.03, η2 = 0.20; main effect) and post‐hoc analysis revealed a difference between BL and 4 week (p = 0.02). There were no changes in any other clinical or additional measures of cardiovascular function. The small increase in cardiac apical rotation observed after 4 weeks of training may indicate an early change in cardiac function. A larger overall training stimulus may be needed to elicit other cardiovascular function changes.

show abstract

Single-beat determination of global longitudinal speckle strain in patients with atrial fibrillation

et al. 2012

View full text Add to dashboard Cite

show abstract

Global longitudinal strain by two-dimensional speckle tracking imaging predicts exercise capacity in patients with chronic heart failure

Abstract: Global longitudinal strain at rest could possibly predict exercise capacity, which appeared to be more useful than LVEF, E/E', and GCS in CHF patients with reduced LVEF.

Cited by 5 publications

References 26 publications

Diagnostic Accuracy of Global Longitudinal Strain for Detecting Exercise Intolerance in Patients with Ischemic Heart Disease

Diagnostic Accuracy of Global Longitudinal Strain for Detecting Exercise Intolerance in Patients with Ischemic Heart Disease

Cardiovascular responses to high‐intensity stair climbing in individuals with coronary artery disease

Single-beat determination of global longitudinal speckle strain in patients with atrial fibrillation

Contact Info

Product

Resources

About