Diagnostic Accuracy of Global Longitudinal Strain for Detecting Exercise Intolerance in Patients with Ischemic Heart Disease

Zhang, Sisi; Liu, Yujian; Jiang, Luying; Wang, Zhaozhao; Liu, Wanjun; Zuo, Houjuan

doi:10.3390/jcdd10010010

Cited by 2 publications

(2 citation statements)

References 41 publications

(42 reference statements)

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“…To date, no study has examined the relationship between LV GLS and physical performance in athletes recovering from COVID-19. However, in patients with ischemic heart disease (IHD), LV GLS is associated with decreased maximal oxygen uptake, which is an independent risk factor for adverse cardiovascular events ( 50 ). In addition, LV GLS correlated independently with peak VO 2 in studies of patients with reduced (rEF) and pEF and was superior to LV EF in identifying patients with reduced exercise capacity ( 51 – 53 ).…”

Section: Discussionmentioning

confidence: 99%

Assessment of myocardial function and cardiac performance using left ventricular global longitudinal strain in athletes after COVID-19: a follow-up study

Schellenberg,

Matits,

Bizjak

et al. 2023

Front. Cardiovasc. Med.

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BackgroundIt has not yet been conclusively determined whether reduced left ventricular global longitudinal strain (LV GLS) after COVID-19 contributes to a reduction in exercise capacity. Our own studies showed a possible mild myocardial involvement in the form of reduced LV GLS in athletes after COVID-19 compared with healthy athletes. The aims of this prospective follow-up study were to investigate the development of LV GLS over a 3-month period in athletes after COVID-19 and the possible relationship between LV GLS and physical performance.MethodsLV GLS was determined in four-, two-, and three-chamber views and assessed offline by a blinded investigator in 96 recreational athletes (mean age 33.15 ± 12.40 years, 53 male, peak VO2 38.82 ± 11.14 ml/min/kg) at a median of two (t0) and five months (t1) after COVID-19. Cardiopulmonary exercise testing (CPET) was performed on a bicycle ergometer on both examination dates.ResultsLV GLS improved significantly between t0 and t1 (t0 −18.82 ± 2.02 vs. t1 −19.46 ± 2.05, p < 0.001). Echocardiographic and spiroergometric parameters were within the normal clinical reference range. Maximum power increased significantly from t0 to t1 (t0 283.17 ± 83.20 vs. t1 286.24 ± 85.22 Watt, p = 0.009) and there was a trend toward increased peak oxygen uptake (t0 36.82 ± 11.14 vs. t1 38.68 ± 10.26 ml/min/kg, p = 0.069). We found no correlation between LV GLS and performance parameters, except for the respiratory exchange ratio (RER) [ρ −0.316, (−0.501; −0.102), p < 0.050].ConclusionsSignificant improvement in LV GLS approximately five months after COVID-19 may be due to mild myocardial involvement during or shortly after COVID-19, which seems to recover. There was no correlation between LV GLS and performance parameters, except for an inverse correlation of LV GLS and RER, suggesting insufficient exercise intolerance at lower GLS values. Further studies on the development of GLS in athletes or in the general population with moderate and severe disease courses would be informative as well as the comparison of pre-COVID-19 with post-COVID-19 echocardiography to evaluate the effects of COVID-19 on cardiac function.

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Section: Discussionmentioning

confidence: 99%

Assessment of myocardial function and cardiac performance using left ventricular global longitudinal strain in athletes after COVID-19: a follow-up study

Schellenberg,

Matits,

Bizjak

et al. 2023

Front. Cardiovasc. Med.

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“…Regional wall motion abnormality (RWMA) predicts long-term mortality in coronary heart patients (1)(2)(3). Diagnosing heart failure (HF) with preserved ejection fraction (HFpEF) is challenging due to the lack of standardized criteria for myocardial dysfunction (4,5).…”

Section: Introductionmentioning

confidence: 99%

Influence of electrolyte imbalance on regional wall motion abnormalities in STEMI patients of North Indian origin

Shiraz Rizvi,

Sunny,

Wani

et al. 2023

Front. Cardiovasc. Med.

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Assessing regional wall motion abnormalities (RWMA) in the myocardium may provide early diagnosis and treat chronic remodeling in STEMI patients. We assessed RWMA in 217 subjects with anterior STEMI admitted to Era University Hospital in Lucknow, UP, India. Besides abnormalities in the LAD territory, sub-sets of patients exhibited diffuse regional myocardial dysfunction. Interestingly, variations in serum electrolytes, specifically sodium and potassium, significantly affected the distribution and frequency of RWMA. Notably, RWMA occurred in the basal septum, apical septum, apex, and lateral wall in the anterior STEMI group. Additionally, the rate of regional dysfunction varied with serum urea and creatinine levels. This suggests that anterior STEMI can manifest myocardial abnormalities beyond the LAD territory. These findings indicate that ST-segment elevation might not be specific, possibly influenced by electrolyte changes affecting cardiac rhythm. Therefore, diagnosing and correcting region-specific wall motion abnormalities and electrolyte imbalances may improve outcomes in STEMI patients.

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Diagnostic Accuracy of Global Longitudinal Strain for Detecting Exercise Intolerance in Patients with Ischemic Heart Disease

Cited by 2 publications

References 41 publications

Assessment of myocardial function and cardiac performance using left ventricular global longitudinal strain in athletes after COVID-19: a follow-up study

Assessment of myocardial function and cardiac performance using left ventricular global longitudinal strain in athletes after COVID-19: a follow-up study

Influence of electrolyte imbalance on regional wall motion abnormalities in STEMI patients of North Indian origin

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