Global identification of circular RNAs in chronic myeloid leukemia reveals hsa_circ_0080145 regulates cell proliferation by sponging miR-29b

Liu, Jianhua; Kong, Fanjiu; Lou, Shuhang; Yang, Dongchang; Gu, Linping

doi:10.1016/j.bbrc.2018.08.154

Cited by 36 publications

(24 citation statements)

References 27 publications

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“…Additionally, circRNA expression profiles display that circ_0001017 and circ_0061276 are correlated with longer OS in gastric cancer patients [25]. As for hematological malignancies, only one study exhibits that circ_100053 contributes to leukemogenesis in chronic myeloid leukemia (CML) and predicts increased resistance to imatinib as well as poor survival in CML patients [26]. Although the correlation of several specific circRNAs with patients' prognosis in solid tumors as well as hematological malignancy has been reported, the correlation of circRNAs with prognosis in MM is still unknown [27].…”

Section: Discussionmentioning

confidence: 99%

Comprehensive profiling of circular RNA expressions reveals potential diagnostic and prognostic biomarkers in multiple myeloma

et al. 2020

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Background: This study aimed to explore the heterogeneity of circRNA expression pattern via microarray, and further evaluate the potential of 10 specific circRNAs as diagnostic and prognostic biomarkers in multiple myeloma (MM). Methods:In exploration stage (stage I), circRNA expression profiles were detected by the microarray in bone marrow plasma cells from 4 MM patients and 4 healthy controls (HCs), and bioinformatic analyses were performed. In validation stage (stage II), top 10 upregulated and top 10 downregulated circRNAs identified in stage I were detected in 60 MM patients and 30 HCs for further validation; the diagnostic and prognostic values of these circRNAs in MM patients were analyzed.Results: In stage I, 122 upregulated and 260 downregulated circRNAs were identified in MM patients compared with HCs. GO, KEGG and pathway enrichment analyses revealed that these circRNAs were implicated in neoplastic pathways such as MAPK and VEGF signaling pathways. In stage II, circ-PTK2, circ-RNF217, circ-RERE, circ-NAGPA and circ-KCNQ5 were validated to be upregulated and circ-AFF2, circ-WWC3, circ-DNAJC5, circ-KLHL2, circ-IQGAP1 and circ-AL137655 were validated to be downregulated in MM compared with controls. Circ-PTK2 and circ-RNF217 were correlated with poor treatment response and survival, while circ-AFF2 predicted good treatment response and survival in MM patients. Conclusions:This study provides valuable reference for profound understanding about circRNA expression patterns in MM, and validates that circ-PTK2, circ-RNF217 and circ-AFF2 might serve as potential prognostic biomarkers in MM.

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Section: Discussionmentioning

confidence: 99%

Comprehensive profiling of circular RNA expressions reveals potential diagnostic and prognostic biomarkers in multiple myeloma

et al. 2020

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“…For example, circBA9.3 that derived from BCR-ABL1 can efficiently promote proliferation and inhibit apoptosis of cancer cells, and promote resistance against tyrosine kinase inhibitors therapy in chronic myelogenous leukemia [3]. hsa_circ_0080145 knockdown significantly suppressed chronic myeloid leukemia (CML) cell proliferation by acting as a miR-29b sponge [4].…”

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confidence: 99%

Circular RNA circHIPK3 serves as a prognostic marker to promote chronic myeloid leukemia progression

Feng¹,

Nie²,

Huang³

et al. 2020

neo

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Increasing evidence demonstrate that circular RNAs (circRNAs) play critical role in regulation of gene expression, which participate in the pathogenesis of cancer, including chronic myeloid leukemia (CML). In this study, we aimed to investigate the expression profiling of circHIPK3 in CML. We found that circHIPK3 was significantly upregulated in peripheral blood mononuclear cells (PBMC) and serum samples from CML compared with healthy controls. High circHIPK3 expression predicted a poor outcome of CML patients. Further loss-function experiments suggested the oncogenic role of circHIPK3 in CML. Our findings provide insights on the role of circHIPK3 in the development and treatment of CML.

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“…Increasing evidence indicates that circRNAs are preferentially located and function in the cytoplasm, and they function as microRNA (miRNA) sponges to affect translation or bind directly to proteins regulating the protein function and localization . In this study, bioinformatics analysis identified miR‐760 and SOCS3 as the downstream targets of hsa_circ_0007874 (Figure A).…”

Section: Resultsmentioning

confidence: 82%

Upregulation of hsa_circ_0007874 suppresses the progression of ovarian cancer by regulating the miR‐760/SOCS3 pathway

Yu²,

Zhang

et al. 2020

Cancer Medicine

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Ovarian cancer (OVA) is a fatal and common malignancy in women worldwide. Circular RNAs (circRNAs) consist of a family of circular endogenous RNAs generated by selective splicing, and they are involved in many diseases. Previous studies reported that hsa_circ_0007874 is aberrantly expressed in cancer and functions in tumorigenesis. While the hsa_circ_0007874 role in OVA is unclear. Here, we detected the hsa_circ_0007874 expression in OVA cell lines using Rt‐qPCR. Hsa_circ_0007874 subcellular localization was confirmed by fluorescence in situ hybridization. The relationship between hsa_circ_0007874, microRNAs (miRNAs), and relative protein levels was assessed using the luciferase reporter assays. Results verified that hsa_circ_0007874 is downregulated in OVA cell lines. hsa_circ_0007874 overexpression decreased the OVA cell migration and proliferation in vitro and in vivo. Bioinformatics and luciferase reporter assays confirmed that miR‐760 and SOCS3 are the downstream targets of hsa_circ_0007874. Downregulation of SOCS3 or miR‐760 overexpression restored the migration and proliferation ability of SKOV3 or A2780 cells overexpressing hsa_circ_0007874. Downregulation of SOCS3 restored the proliferation and migration in miR‐760 knockdown SKOV3 and A2780 cells. In summary, the data suggest that hsa_circ_0007874 acts as a tumor suppressor by regulating the miR‐760/SOCS3 axis, highlighting its potential as an effective therapeutic target for OVA.

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Global identification of circular RNAs in chronic myeloid leukemia reveals hsa_circ_0080145 regulates cell proliferation by sponging miR-29b

Cited by 36 publications

References 27 publications

Comprehensive profiling of circular RNA expressions reveals potential diagnostic and prognostic biomarkers in multiple myeloma

Comprehensive profiling of circular RNA expressions reveals potential diagnostic and prognostic biomarkers in multiple myeloma

Circular RNA circHIPK3 serves as a prognostic marker to promote chronic myeloid leukemia progression

Upregulation of hsa_circ_0007874 suppresses the progression of ovarian cancer by regulating the miR‐760/SOCS3 pathway

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