Circular RNA circHIPK3 serves as a prognostic marker to promote chronic myeloid leukemia progression

Feng, Xianqi; Nie, Shumin; Huang, Jiuzuo; Li, T L; Zhou, Jingjing; Wang, W; Zhuang, Likun; Meng, Fanjun

doi:10.4149/neo_2018_181129n908

Cited by 30 publications

(25 citation statements)

References 16 publications

(21 reference statements)

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“…Circ_0075001 was overexpressed in M0 or M1 subtype of AML patients and significantly downregulated in M2, M4 and M5 subgroups, showing the potential to distinguish the differentiation degree of the AML [107]. The high expression of circHIPK3 in serum of CML patients was related to Sokal relative risk, an independent factor of CML prognosis, and shorter OS, indicating poor clinical outcome [70]. The level of circ-RPL15 was negatively correlated to the mutation state of immunoglobulin heavy chain (IGHV) gene, predicting poorer OS [108].…”

Section: Promising Biomarkers For Diagnosis and Prognosismentioning

confidence: 92%

“…CircHIPK3 could downregulate miR-421, leading to the increased FOXO3a expression, thereby inhibiting pyroptosis and releasing IL-1β and IL-18 [69]. Previous studies have found that the high expression of circHIPK3 in CML was significantly associated with poor prognosis [70]. Besides, AKT/FOXO3a pathway was involved in the apoptosis of AML [71].…”

Section: Regulating Pyroptosismentioning

confidence: 99%

“…The high expression of circHIPK3 in serum of CML patients was related to Sokal relative risk, an independent factor of CML prognosis, and shorter OS, indicating poor clinical outcome [ 70 ]. The level of circ-RPL15 was negatively correlated to the mutation state of immunoglobulin heavy chain (IGHV) gene, predicting poorer OS [ 108 ].…”

Section: Potential Clinical Application Of Circrnasmentioning

confidence: 99%

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The functions and clinical significance of circRNAs in hematological malignancies

et al. 2020

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With covalently closed circular structures, circular RNAs (circRNAs) were once misinterpreted as by-products of mRNA splicing. Being abundant, stable, highly conserved, and tissue-specific, circRNAs are recently identified as a type of regulatory RNAs. CircRNAs bind to certain miRNAs or proteins to participate in gene transcription and translation. Emerging evidence has indicated that the dysregulation of circRNAs is closely linked to the tumorigenesis and treatment response of hematological malignancies. CircRNAs play critical roles in various biological processes, including tumorigenesis, drug resistance, tumor metabolism, autophagy, pyroptosis, and ferroptosis. The N6-methyladenosine modification of circRNAs and discovery of fusion-circRNAs provide novel insights into the functions of circRNAs. Targeting circRNAs in hematological malignancies will be an attractive treatment strategy. In this review, we systematically summarize recent advances toward the novel functions and molecular mechanisms of circRNAs in hematological malignancies, and highlight the potential clinical applications of circRNAs as novel biomarkers and therapeutic targets for future exploration.

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Section: Promising Biomarkers For Diagnosis and Prognosismentioning

confidence: 92%

Section: Regulating Pyroptosismentioning

confidence: 99%

Section: Potential Clinical Application Of Circrnasmentioning

confidence: 99%

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The functions and clinical significance of circRNAs in hematological malignancies

et al. 2020

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“…Induced circHIPK3 expression predicted a poor outcome of CML patients, and circ_100053 might be associated with imatinib resistance in CML. 235,236 In addition, circ_0080145 was found to be up-regulated in CML, and silence of circ_0080145 significantly inhibited cell proliferation of CML by sponging miR-29b. 237 Taken together, circRNAs were distributed broadly in myeloid leukemia, and abnormal expressions of circRNAs were closely related to the progression and tumorigenesis of myeloid leukemia including AML and CML.…”

Section: Myeloid Leukemiamentioning

confidence: 96%

<p>Biological Roles and Mechanisms of Circular RNA in Human Cancers</p>

Tang

Hann

2020

OTT

136

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Circular RNA (circRNA) is an intriguing class of RNA with covalently closedloop structure and is highly stable and conservative. As new members of the ncRNAs, the function, mechanism, potential diagnostic biomarker, and therapeutic target have raised increased attention. Most circRNAs are presented with characteristics of abundance, stability, conservatism, and often exhibiting tissue/developmental-stage-specific manner. Over 30,000 circRNAs have been identified with their unique structures to maintain stability more easily than linear RNAs. An increased numbers of circRNAs are dysregulated and involved in several biological processes of malignance, such as tumorigenesis, growth, invasion, metastasis, apoptosis, and vascularization. Emerging evidence suggests that circRNAs play important roles by acting as miRNA sponge or protein scaffolding, autophagy regulators, and interacting with RNA-binding protein (RBP), which may potentially serve as a novel promising biomarker for prevention, diagnosis and therapeutic target for treatment of human cancer with great significance either in scientific research or clinic arena. This review introduces concept, major features of circRNAs, and mainly describes the major biological functions and clinical relevance of circRNAs, as well as expressions and regulatory mechanisms in various types of human cancer, including pathogenesis, mode of action, potential target, signaling regulatory pathways, drug resistance, and therapeutic biomarkers. All of which provide evidence for the potential utilities of circRNAs in the diagnosis and treatment of cancer.

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“…[8][9][10][11][12] Previous studies have shown that circHIPK3 spongs miR-145-5p, miR-124, miR-558, miR-637, miR-193a, miR-338-3p, and miR-637 to regulate oxaliplatin-resistance, proliferation, tube formation, invasion, autophagy, migration, and apoptosis in lung cancer, preeclampsia, gastric cancer, colorectal cancer, chronic myeloid leukemia, bladder cancer, prostate cancer. [13][14][15][16][17][18][19][20] However, the role and function of circHIPK3 have not been revealed in PC.…”

Section: Introductionmentioning

confidence: 99%

<p>CircHIPK3 Promotes Gemcitabine (GEM) Resistance in Pancreatic Cancer Cells by Sponging miR-330-5p and Targets RASSF1</p>

Liu¹,

Li²,

Luo³

et al. 2020

CMAR

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Background: Pancreatic cancer is one of the most common malignant diseases in the world. Gemcitabine chemotherapy remains the most important clinical treatment. However, research found that pancreatic cancer cells have chemoresistance to gemcitabine and the effect is not satisfactory. Therefore, it is urgent to find an effective early diagnosis and treatment strategy. Circular RNA is one of the most popular prognostic biomarkers in GEM-resistant PC. Materials and Methods: The present study was designed to evaluate the role of circHIPK3 in PC. The expression of circHIPK3 in PC tissues and cells and its effect on proliferation, migration, invasion, EMT, and apoptosis were investigated in vitro; its effect on tumor xenografts was assessed in vivo. Used bioinformation analysis to predict which miRNAs could potentially interact with circHIPK3, mRNA, and miR-330-5p. Results: RT-PCR showed that the level of circHIPK3 was increased in PC tumor tissues; moreover, circHIPK3 was also increased in GEM-resistant PC tumors tissues and GEMresistant PC cells. Sh-circHIPK3 could knockdown circHIPK3 in PANC-1-GEM and SW-1990-GEM and could significantly inhibit cell proliferation, invasion, migration, EMT and enhance cell apoptosis, compare with control group, the tumor xenografts of circHIPK3 knockdown group were significantly smaller. CircHIPK3 served as a sponge for miR-330-5p, and miR-330-5p directly bound to the 3′ UTR of RASSF1 were revealed by dual luciferase assay and RIP in PC cells. CircHIPK3 knockdown of RASSF1 expression could neutralize the cytological function of PC cells by miR-330-5p inhibitor mediated GEM-resistance. Conclusion: CircHIPK3 promotes gemcitabine (GEM) resistance in pancreatic cancer cells by targeting RASSF1 via miR-330-5p and regulates proliferation, invasive, migration, EMT, and apoptosis. Our research revealed that circHIPK3 may be a novel biomarker in GEMresistant PC and could be used as a prognostic target.

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Circular RNA circHIPK3 serves as a prognostic marker to promote chronic myeloid leukemia progression

Cited by 30 publications

References 16 publications

The functions and clinical significance of circRNAs in hematological malignancies

The functions and clinical significance of circRNAs in hematological malignancies

<p>Biological Roles and Mechanisms of Circular RNA in Human Cancers</p>

<p>CircHIPK3 Promotes Gemcitabine (GEM) Resistance in Pancreatic Cancer Cells by Sponging miR-330-5p and Targets RASSF1</p>

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