Global Epidemiology of Dengue Hemorrhagic Fever: An Update

Sanyaolu, Adekunle; Okorie, Chuku; Badaru, Olanrewaju; Adetona, Khadijat; Ahmed, Miriam; Akanbi, Odunayo; Foncham, Juanita; Kadavil, S K; Likaj, Lorena; Miraaj-Raza, Sarah; Pearce, Erika L.; Sylvester, Roberta; Wallis, Elizabeth

doi:10.15406/jhvrv.2017.05.00179

Cited by 33 publications

(30 citation statements)

References 32 publications

(62 reference statements)

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“…The complement system and NK cells are also recruited to neutralize the virus. The B cells also produce memory B cells in case the patient is infected again however, these memory cells will only be able to help if the patient is infected with the same serotype again [64,65]. The figure was created using BioRender and exported under the terms of premium subscription.…”

Section: Immune Response Of Human Body Against Dengue Virusmentioning

confidence: 99%

Dengue Outbreak is a Global Recurrent Crisis: Review of the Literature

et al. 2020

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This review features a generalized overview of dengue outbreaks, dengue pathogenesis, symptoms, immune response, diagnosis methods and preventive measures which facilitates the better understanding of the global expansion and concerns relating to the disease. Recent Findings: A recent study showed that natural killer cells of the infected person become activated soon after the infection which may help in treatment and vaccine development. A research team has also produced synthetically engineered mosquitoes that can prevent the transmission and dissemination of the dengue virus by the activation of an antibody. Furthermore, a mutation in the protein envelope of the dengue virus leads to variation in shapes, developing resistance towards the vaccine. Summary: The increasing number of reported cases indicated the worldwide distribution of the mosquito vectors, which was further facilitated by the growth in the shipping and commerce industries. The immune system, through activation of the innate and adaptive immune responses, facilitates the recruitment of an array of leukocytes which help neutralize the virus. However, the 4 different viral serotypes increases the risk of a life-threatening secondary infection due to the varying serotypes. Apart from the laboratory standard PRNT method, several other dengue detection methods such as ELISA, RT-LAMP and several optical, microfluidic and electrochemical methods have been developed. Since Dengvaxia® (CYD-TDV) has its own set of drawbacks and limitations, several companies have been investing for the production of more potential vaccines that are currently in trial.

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Section: Immune Response Of Human Body Against Dengue Virusmentioning

confidence: 99%

Dengue Outbreak is a Global Recurrent Crisis: Review of the Literature

et al. 2020

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“…Infeksi dari salah satu serotipe memberikan kekebalan dalam jangka panjang pada serotipe yang sama, namun tidak memberi kekebalan pada serotipe yang berbeda. Infeksi dengue sekunder berhubungan dengan peningkatan dampak derajat keparahan pada penderita (World Health Organisation (WHO), 2015; Sanyaolu et al, 2017). Faktor lingkungan merupakan faktor yang kompleks meliputi lingkungan biotik, abiotik dan sosial.…”

Section: Pendahuluanunclassified

“…Curah hujan akan mempengaruhi bertambahnya habitat nyamuk vektor DBD terutama di luar rumah. Suhu yang hangat akan mempengaruhi kecepatan replikasi virus dan perkembangan larva vektor (Sanyaolu et al, 2017).…”

Section: Pendahuluanunclassified

Indikator Entomologi Dan Risiko Penularan Demam Berdarah Dengue (Dbd) Di Pulau Jawa, Indonesia

Trapsilowati¹,

Anggraeni

Prihatin

et al. 2019

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One of dengue hemorrhagic fever (DHF) transmission risk factors is presence of vectors, especially Aedes aegypti. Vector surveillance is carried out to determine vectors distribution, vector density and risk of transmission. The larva survey is a common and easy vector surveillance method. This study aims to describe the cases and deaths due to DHF and entomological indicators in Java. This study was further analysis of Special Research Disease of Vector and Reservoir (Rikhus Vektora). Data collection was conducted in 2016 - 2018. The study locations were five provinces on Java Island i.e. East Jawa, West Jawa, Banten, DI Yogyakarta, DKI Jakarta and three districts were each taken. The data of DHF cases and entomology were analyzed descriptively. The results of the study show that the last two years were 50% districts experienced an increase in DHF cases and 38.9% an increase in deaths. The highest house index was 50% and lowest was 9%, highest larval free rate was 91% and lowest was 50%. The highest container index was 26.48%, lowest was 3.68%, and the highest breteau index was 67, lowest was 11. As many as 73.3% districts have the most water containers were buckets and 26.7% most water containers were bathtubs. Java Island has a medium to high potential region toward DHF transmission occurs. Increased knowledge and skills for eradication mosquito correctly by individually and community needs to be planned and implemented sustainable, to increase community participation as well.

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“…4 Manifestasi klinis dari penyakit demam berdarah dengue ini meliputi demam tinggi secara mendadak, sakit kepala, nafsu makan berkurang, mialgia dan artralgia, ruam kulit yang muncul tiga hingga empat hari setelah awal timbulnya demam, nyeri retroorbital, fotofobia, limfadenopati, perdarahan ringan dan tes turniket positif. 5 Manifestasi yang terkait dengan kebocoran plasma dan perdarahan berpotensi untuk menyebabkan syok hipovolemik. 6 Manajemen klinis infeksi dengue berfokus pada perawatan suportif, dengan penekanan khusus pada manajemen cairan yang cermat.…”

Section: Pendahuluanunclassified

Efektivitas Biaya Terapi Cairan Kristaloid dan Koloid pada Pasien Anak Demam Berdarah di Rumah Sakit PKU Muhammadiyah Bantul

Nasriyah¹,

Munawwarah²,

Perwitasari³

2019

ijcp

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AbstrakDemam berdarah dengue (DBD) merupakan penyakit yang disebabkan oleh virus dengue yang ditularkan melalui gigitan nyamuk Aedes aegypti. Kunci keberhasilan terapi pada penyakit demam berdarah adalah pemberian cairan termasuk jenis dan jumlahnya. Dari aspek biaya terapi, cairan koloid diketahui lebih mahal dibandingkan cairan kristaloid. Tujuan dari penelitian ini adalah untuk mengetahui efektivitas biaya terapi cairan kristaloid dan koloid pada pasien anak demam berdarah periode Januari 2018 sampai Juni 2018 di Rumah Sakit PKU Muhammadiyah Bantul. Penelitian ini menggunakan desain penelitian eksperimental single blind randomized clinical trial. Sejumlah 48 pasien anak yang memenuhi syarat inklusi dibagi menjadi dua kelompok yaitu kelompok intervensi (n=24) yang mendapatkan terapi cairan koloid berupa inisial cairan gelafusal dan kelompok kontrol (n=24) yang mendapatkan terapi cairan kristaloid tunggal berupa ringer laktat. Data efektivitas (lama rawat inap) dan total biaya medis dianalisis menggunakan independent t-test dan rumus average cost-effectiveness ratio (ACER). Terdapat perbedaan yang signifikan lama rawat inap antara kelompok cairan kristaloid dibandingkan kelompok cairan koloid (p<0,05). Hasil penelitian menunjukkan perbandingan nilai ACER yaitu nilai ACER kelompok koloid (Rp28.560/efektivitas) lebih rendah dari nilai ACER kelompok kristaloid (Rp62.328/ efektivitas). Kesimpulan dari penelitian ini adalah terapi cairan koloid lebih cost-effective dibandingkan cairan kristaloid. AbstractDengue hemorrhagic fever (DHF) is a disease caused by the dengue virus which is transmitted through the bite of the Aedes aegypti mosquito. The key to the success of therapy in dengue fever is the administration of fluids including types and quantities. Based on its cost, colloid fluid therapy are known to be more expensive than crystalloid fluid therapy. The purpose of this study was to determine the costeffectiveness of crystalloid and colloid fluid therapy in dengue fever patients in the period of January-June 2018 at PKU Muhammadiyah Hospital Bantul. This study employed an experimental single blind randomized clinical trial design. A total of 48 pediatric patients who met the inclusion requirements were divided into two groups, namely the intervention group (n=24) who received colloid fluid therapy in the form of initial gelafusal fluid and control group (n=24) who received single crystalloid fluid therapy in the form of ringer lactate. Effectiveness data (length of stay) and total medical costs were analyzed using independent t-test and the average cost-effectiveness ratio (ACER) formula. There was a significant difference in length of stay between groups of crystalloid fluid compared to the group of colloid fluid (p<0.05). The ACER values of the colloid group (28,560 IDR/effectiveness) was lower than the crystalloid group (62,328 IDR/effectiveness). The conclusion of this study is that colloid fluid therapy group is more cost-effective than crystalloid fluid group.

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Global Epidemiology of Dengue Hemorrhagic Fever: An Update

Cited by 33 publications

References 32 publications

Dengue Outbreak is a Global Recurrent Crisis: Review of the Literature

Dengue Outbreak is a Global Recurrent Crisis: Review of the Literature

Indikator Entomologi Dan Risiko Penularan Demam Berdarah Dengue (Dbd) Di Pulau Jawa, Indonesia

Efektivitas Biaya Terapi Cairan Kristaloid dan Koloid pada Pasien Anak Demam Berdarah di Rumah Sakit PKU Muhammadiyah Bantul

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