Global dynamics of selective attention and its lapses in primary auditory cortex

Lakatos, Péter L.; Barczak, Annamaria; Neymotin, Samuel A.; McGinnis, Tammy; Ross, Deborah; Javitt, Daniel C.; O’Connell, Monica N.

doi:10.1038/nn.4386

Cited by 120 publications

(182 citation statements)

References 61 publications

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“…This finding may seem incongruent with a proposed tradeoff between the two neural strategies53. However, it is important that although increased alpha amplitude does not reduce entrainment strength, it does reduce entrainment’s effects on behaviour.…”

Section: Discussionmentioning

confidence: 84%

“…However, a more fine-grained examination of trial-by-trial tradeoffs between measures could reveal more subtle dynamical shifts between strategies or processing modes53. Such an analysis would necessitate a behavioural measure other than neuro-driven behavioural modulation, as this particular measure requires aggregation over many trials to calculate.…”

Section: Discussionmentioning

confidence: 99%

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Aging affects the balance of neural entrainment and top-down neural modulation in the listening brain

et al. 2017

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Healthy aging is accompanied by listening difficulties, including decreased speech comprehension, that stem from an ill-understood combination of sensory and cognitive changes. Here, we use electroencephalography to demonstrate that auditory neural oscillations of older adults entrain less firmly and less flexibly to speech-paced (∼3 Hz) rhythms than younger adults’ during attentive listening. These neural entrainment effects are distinct in magnitude and origin from the neural response to sound per se. Non-entrained parieto-occipital alpha (8–12 Hz) oscillations are enhanced in young adults, but suppressed in older participants, during attentive listening. Entrained neural phase and task-induced alpha amplitude exert opposite, complementary effects on listening performance: higher alpha amplitude is associated with reduced entrainment-driven behavioural performance modulation. Thus, alpha amplitude as a task-driven, neuro-modulatory signal can counteract the behavioural corollaries of neural entrainment. Balancing these two neural strategies may present new paths for intervention in age-related listening difficulties.

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Section: Discussionmentioning

confidence: 84%

Section: Discussionmentioning

confidence: 99%

Aging affects the balance of neural entrainment and top-down neural modulation in the listening brain

et al. 2017

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“…These dynamical ensembles are best recognized in the case of gamma, 17 but there is also evidence of tying cells of particular cortical layers together with alpha. 21, 33 …”

Section: Resultsmentioning

confidence: 99%

Tracking recurrence of correlation structure in neuronal recordings

Neymotin

Talbot

Jung

et al. 2017

Journal of Neuroscience Methods

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Background Correlated neuronal activity in the brain is hypothesized to contribute to information representation, and is important for gauging brain dynamics in health and disease. Due to high dimensional neural datasets, it is difficult to study temporal variations in correlation structure. New Method We developed a multiscale method, Population Coordination (PCo), to assess neural population structure in multiunit single neuron ensemble and multi-site local field potential (LFP) recordings. PCo utilizes population correlation (PCorr) vectors, consisting of pair-wise correlations between neural elements. The PCo matrix contains the correlations between all PCorr vectors occurring at different times. Results We used PCo to interpret dynamics of two electrophysiological datasets: multisite LFP and single unit ensemble. In the LFP dataset from an animal model of medial temporal lobe epilepsy, PCo isolated anomalous brain states, where particular brain regions broke off from the rest of the brain’s activity. In a dataset of rat hippocampal single-unit recordings, PCo enabled visualizing neuronal ensemble correlation structure changes associated with changes of animal environment (place-cell remapping). Comparison with Existing Method(s) PCo allows directly visualizing high dimensional data. Dimensional reduction techniques could also be used to produce dynamical snippets that could be examined for recurrence. PCo allows intuitive, visual assessment of temporal recurrence in correlation structure directly in the high dimensionality dataset, allowing for immediate assessment of relevant dynamics at a single site. Conclusions PCo can be used to investigate how neural correlation structure occurring at multiple temporal and spatial scales reflect underlying dynamical recurrence without intermediate reduction of dimensionality.

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“…In fact, ERFs are most likely dominated by intracellular currents, rather than by the extracellular return currents measured as ERPs. Thereby, magnetic field recordings could greatly refine current-source density estimates, measurements of increasing importance (Lakatos et al, 2016). The vectorial nature of the ERF recordings allows the identification of the current flow direction after combination of merely three GMR sensors.…”

Section: Discussionmentioning

confidence: 99%

In Vivo Magnetic Recording of Neuronal Activity

Caruso

Wunderle

Lewis

et al. 2017

Neuron

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SUMMARY Neuronal activity generates ionic flows and thereby both magnetic fields and electric potential differences, i.e. voltages. Voltage measurements are widely used, but suffer from isolating and smearing properties of tissue between source and sensor, are blind to ionic flow direction, and reflect the difference between two electrodes, complicating interpretation. Magnetic field measurements could overcome these limitations, but have been essentially limited to magnetoencephalography (MEG), using centimeter-sized, helium-cooled extracranial sensors. Here, we report on in vivo magnetic recordings of neuronal activity from visual cortex of cats with magnetrodes, specially developed needle-shaped probes carrying micron-sized, non-cooled magnetic sensors based on spin electronics. Event-related magnetic fields inside the neuropil were on the order of several nanoteslas, informing MEG source models and efforts for magnetic field measurements through MRI. Though the signal-to-noise ratio is still inferior to electrophysiology, this proof of concept demonstrates the potential to exploit the fundamental advantages of magnetophysiology.

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Global dynamics of selective attention and its lapses in primary auditory cortex

Cited by 120 publications

References 61 publications

Aging affects the balance of neural entrainment and top-down neural modulation in the listening brain

Aging affects the balance of neural entrainment and top-down neural modulation in the listening brain

Tracking recurrence of correlation structure in neuronal recordings

In Vivo Magnetic Recording of Neuronal Activity

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