In Vivo Magnetic Recording of Neuronal Activity

Caruso, Laure; Wunderle, Thomas; Lewis, Chris; Valadeiro, João; Trauchessec, Vincent; Rosillo, Josué Trejo; Amaral, Joana D.; Ni, Jianguang; Jendritza, Patrick; Fermon, C.; Cardoso, S.; Fries, Pascal; Pannetier‐Lecœur, M.

doi:10.1016/j.neuron.2017.08.012

Cited by 53 publications

(65 citation statements)

References 35 publications

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“…[ 68 ] The GMR based micro‐probes permitted the miniaturization and shaping required for in vivo/vitro magnetophysiology and represented a new fundamental tool to investigate the local sources of neuronal magnetic activities. [ 80 ]…”

Section: Mmg Sensing Technologiesmentioning

confidence: 99%

Miniaturized Magnetic Sensors for Implantable Magnetomyography

Zuo

Heidari

Farina

et al. 2020

Adv Materials Technologies

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Magnetism‐based systems are widely utilized for sensing and imaging biological phenomena, for example, the activity of the brain and the heart. Magnetomyography (MMG) is the study of muscle function through the inquiry of the magnetic signal that a muscle generates when contracted. Within the last few decades, extensive effort has been invested to identify, characterize and quantify the magnetomyogram signals. However, it is still far from a miniaturized, sensitive, inexpensive and low‐power MMG sensor. Herein, the state‐of‐the‐art magnetic sensing technologies that have the potential to realize a low‐profile implantable MMG sensor are described. The technical challenges associated with the detection of the MMG signals, including the magnetic field of the Earth and movement artifacts are also discussed. Then, the development of efficient magnetic technologies, which enable sensing pico‐Tesla signals, is advocated to revitalize the MMG technique. To conclude, spintronic‐based magnetoresistive sensing can be an appropriate technology for miniaturized wearable and implantable MMG systems.

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Section: Mmg Sensing Technologiesmentioning

confidence: 99%

Miniaturized Magnetic Sensors for Implantable Magnetomyography

Zuo

Heidari

Farina

et al. 2020

Adv Materials Technologies

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“…Each repetition will therefore theoretically lead to R N =R 1 /N. Finally, the yokes are connected in a current-in-plane (CIP) configuration by Ta (5)/Cu (150)/Ta (5) contacts and passivated by a protective 150 nm thick Al 2 O 3 layer deposited by sputtering as a last step in the microfabrication process.…”

Section: A Experimental Detailsmentioning

confidence: 99%

Multiple Giant-Magnetoresistance Sensors Controlled by Additive Dipolar Coupling

Torrejón¹,

Solignac²,

Chopin³

et al. 2020

Phys. Rev. Applied

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Vertical packaging of multiple Giant Magnetoresistance (multi-GMR) stacks is a very interesting noise reduction strategy for local magnetic sensor measurements, which has not been reported experimentally so far. Here, we have fabricated multi-GMR sensors (up to 12 repetitions) keeping good GMR ratio, linearity and low roughness. From magnetotransport measurements, two different resistance responses have been observed with a crossover around 5 GMR repetitions: step-like (N<5) and linear (N≥5) behavior, respectively. With the help of micromagnetic simulations, we have analyzed in detail the two main magnetic mechanisms: the Neel coupling distribution induced by the roughness propagation and the additive dipolar coupling between the N free layers.

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“…Since the permeability of the biological tissues is like the permeability of free space, the magnetic field recordings from the brain have high spatial as well as temporal resolution. In this respect, linear MR sensors [138][139][140][141][142] have been investigated for neural signal recording.…”

Section: Mr Biosensors For Brain Mappingmentioning

confidence: 99%

Advances in Magnetoresistive Biosensors

Saha

et al. 2019

Micromachines

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Magnetoresistance (MR) based biosensors are considered promising candidates for the detection of magnetic nanoparticles (MNPs) as biomarkers and the biomagnetic fields. MR biosensors have been widely used in the detection of proteins, DNAs, as well as the mapping of cardiovascular and brain signals. In this review, we firstly introduce three different MR devices from the fundamental perspectives, followed by the fabrication and surface modification of the MR sensors. The sensitivity of the MR sensors can be improved by optimizing the sensing geometry, engineering the magnetic bioassays on the sensor surface, and integrating the sensors with magnetic flux concentrators and microfluidic channels. Different kinds of MR-based bioassays are also introduced. Subsequently, the research on MR biosensors for the detection of protein biomarkers and genotyping is reviewed. As a more recent application, brain mapping based on MR sensors is summarized in a separate section with the discussion of both the potential benefits and challenges in this new field. Finally, the integration of MR biosensors with flexible substrates is reviewed, with the emphasis on the fabrication techniques to obtain highly shapeable devices while maintaining comparable performance to their rigid counterparts.

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In Vivo Magnetic Recording of Neuronal Activity

Cited by 53 publications

References 35 publications

Miniaturized Magnetic Sensors for Implantable Magnetomyography

Miniaturized Magnetic Sensors for Implantable Magnetomyography

Multiple Giant-Magnetoresistance Sensors Controlled by Additive Dipolar Coupling

Advances in Magnetoresistive Biosensors

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