Global distribution pattern of histological subtypes of epithelial ovarian cancer: A database analysis and systematic review

Sung, Pi-Lin; Chang, Yen-Hou; Chao, Kuan-Chong; Chuang, Chi-Mu

doi:10.1016/j.ygyno.2014.02.016

Cited by 94 publications

(83 citation statements)

References 53 publications

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“…26,35,36 This diversity may reflect the geographical and ethnic variations as epithelial ovarian cancer is a disease with a pattern of heterogeneous distribution. 29 In our study the exact cause of risk factors ,which may be environmental have to be studied further. Mucinouscystadenomas are associated with dermoid cysts in 3 to 5%, 30 suggesting that they may be monodermal teratomas of germ cell origin.…”

Section: Soumini G Et Al Int J Reprod Contracept Obstet Gynecol 201mentioning

confidence: 99%

Scenario of ovarian mass lesions at a teaching hospital in Andhra Pradesh, India

Soumini

Sarella

Chaveli

et al. 2015

Int J Reprod Contracept Obstet Gynecol

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Section: Soumini G Et Al Int J Reprod Contracept Obstet Gynecol 201mentioning

confidence: 99%

Scenario of ovarian mass lesions at a teaching hospital in Andhra Pradesh, India

Soumini

Sarella

Chaveli

et al. 2015

Int J Reprod Contracept Obstet Gynecol

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“…1,2 Accumulating evidence suggests that OCCC has distinct clinical and molecular characteristics compared with other histologic subtypes of epithelial ovarian cancer. 3,4 Clinically, patients with advanced-stage OCCC have poorer survival outcomes than those with advanced-stage serous ovarian carcinoma (SOC), whereas patients with early-stage OCCC and SOC have similar survival outcomes.…”

Section: Introductionmentioning

confidence: 99%

Venous thromboembolism, interleukin-6 and survival outcomes in patients with advanced ovarian clear cell carcinoma

Matsuo¹,

Hasegawa²,

Yoshino³

et al. 2015

European Journal of Cancer

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“…Epithelial ovarian cancer (EOC), which is categorized into serous, mucinous, endometrioid and non-clear cell types, accounts for 90% of all ovarian cancer (3,4). The earlier cancer is identified, the better the prognosis; however, ovarian cancer is difficult to detect early, as overt symptoms do not occur until later stages of the disease.…”

Section: Introductionmentioning

confidence: 99%

Association between the rs11614913 variant of miRNA-196a-2 and the risk of epithelial ovarian cancer

Song

Zhao

et al. 2015

Oncology Letters

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Abstract. Polymorphisms in microRNA (miR) genes and their target sites are a distinct classification of variation in the human genome, which are rapidly being identified and investigated in human cancer. A polymorphism in the miR-196a-2 locus has demonstrated significant associations with various types of cancer, including lung, breast, esophageal and gastric tumors. However, miR-196a-2 has not been fully explored in ovarian cancer, which shares similar biological characteristics with other types of cancer. Therefore, the present study aimed to elucidate the association between a single nucleotide polymorphism (SNP) in the mature sequence of miR-196a-2 (rs11614913, T/C) and the clinical features of 479 Chinese patients with epithelial ovarian cancer (EOC). In addition, the biological significance of this polymorphism was investigated in the OVCAR3 ovarian cancer cell line. Risk association was evaluated in 479 cases of EOC patients and 431 controls. SNPs were analyzed by using polymerase chain reaction based restriction fragment length polymorphism assay. miR-196a expression was evaluated with reverse transcription polymerase chain reaction. The influence of miR-196a-2 rs11614913 T/C on EOC cell migration and invasion ability was further investigated in vitro. The results revealed significant differences in the homozygous CC genotype distribution in patients with EOC (n=479), compared with that of the control subjects (n=431; P=0.026). Analysis of the association between genotype and the risk of EOC revealed that individuals who carried the homozygous CC genotype were 1.34-fold more susceptible to EOC, compared with those carrying the wild-type TT and heterozygous CT genotypes [odds ratio, 1.34; 95% confidence interval, 1.04-2.17; P= 0.023].In addition, the role of this polymorphism in the production of mature miR-196a was investigated. Significantly enhanced production of mature miR-196a was revealed in the C-allelic compared with that of the T-allelic miR-196a-2 precursor (P<0.05). Further examination indicated that miR-196a significantly promoted cell migration and invasion ability in the human OVCAR3 ovarian cell line (P<0.05). In conclusion, the results indicated that the miR-196a-2 rs11614913 CC genotype may increase the risks of ovarian cancer by affecting the expression of mature miR-196a and enhancing cell migration/invasion. The current results provided evidence that the T>C polymorphism in the miR-196a-2 precursor may influence tumorigenesis and metastasis in EOC, and suggested that the functional SNP rs11614913 in the promoter region of pri-miR-196a-2 may be a potential indicator of EOC susceptibility in the population analyzed. IntroductionOvarian cancer only accounts for ~4% of cancer cases in women, but it is the eighth most common cause of cancerassociated mortality resulting from gynecological tumors worldwide (1,2). Epithelial ovarian cancer (EOC), which is categorized into serous, mucinous, endometrioid and non-clear cell types, accounts for 90% of all ovarian cancer (3,4). The earlier cancer ...

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Global distribution pattern of histological subtypes of epithelial ovarian cancer: A database analysis and systematic review

Cited by 94 publications

References 53 publications

Scenario of ovarian mass lesions at a teaching hospital in Andhra Pradesh, India

Scenario of ovarian mass lesions at a teaching hospital in Andhra Pradesh, India

Venous thromboembolism, interleukin-6 and survival outcomes in patients with advanced ovarian clear cell carcinoma

Association between the rs11614913 variant of miRNA-196a-2 and the risk of epithelial ovarian cancer

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