Global Comprehensive Literature Review and Meta-Analysis of Brucella spp. in Swine Based on Publications From 2000 to 2020

Abstract

Background: Brucellosis, a zoonotic disease, infects various hosts, including swine and humans. It has reemerged in recent years as a public health concern, and current studies on brucellosis infection in swine have been conducted worldwide. However, no meta-analyses of global brucellosis infection in swine have been published. The aim of this study was to provide an overview of Brucella species (spp.) in swine worldwide and the factors associated with its persistence.Results: We searched seven databases for published epidemiological studies on brucellosis in pigs, including the Chinese National Knowledge Infrastructure, Wanfang Data, SpringerLink, ScienceDirect, Web of Science, the VIP Chinese Journal Database and PubMed. We selected 119 articles published from January 1, 2000 to January 3, 2020 for inclusion in the meta-analysis and analyzed the data using a random-effects model. Funnel plots and Egger's test showed significant publication bias in the included studies. The results of the sensitivity analysis showed that our study was relatively stable and reliable. The prevalence of brucellosis in swine was 2.1% (95% CI: 1.6–2.6), of which the highest infection rate, which was found in Europe, was 17.4% (95% CI: 11.1–24.9). The prevalence in feral pigs (15.0%, 95% CI: 8.4–23.2) was higher than that in domestic pigs (1.1%, 95% CI 0.2–2.5). The prevalence in high-income countries (15.7%, 95% CI 8.0–25.3) was significantly higher than that in middle- (0.8%, 95% CI 0.5–1.1), and low-income countries (0.1%, 95% CI 0.0–0.2). The prevalence was highest in finishing pigs at 4.9% (95% CI 0.9–11.0), and lowest among suckling pigs at 0% (95% CI 0.0–0.5).Conclusion: The Brucella prevalence in pig herds currently is distributed widely throughout the world. In some countries, swine brucellosis may be a neglected zoonotic disease. We recommend long-term monitoring of the prevalence of brucellosis in domestic and wild pig herds. Attention should also be paid to animal welfare on intensive pig farms; controlling the breeding density may play an important role in reducing the spread of brucellosis among pigs.

Immunoassay-based evaluation of rOmp28 protein as a candidate for the identification of Brucella species

“…ml −1 of bacteria required for spreading potential infection [11]. It is also considered to be an important bio-threatening agent from a bio-security perspective and a serious public health concern that requires critical advancements in diagnostic methods for early disease control and prevention [66].…”

First Report of Brucella Seroprevalence in Wild Boar Population in Serbia

“…A global comprehensive literature review and meta-analysis of Brucella in pigs from 2000 to 2020 reported that the overall prevalence of brucellosis in wild boars between 2006 and 2010 was 22.3% [ 27 ], while after 2010, the prevalence gradually decreased after the World Organisation for Animal Health (WOAH) proposed control safety standards for animal production [ 28 ]. De facto , the Brucella seroprevalence in wild boars in Croatia varied through the years, ranging from 1.3% to 27.6% during different periods [ 13 , 14 , 25 ].…”

Swine brucellosis in the state of Maranhão: Prevalence in slaughterhouses without sanitary inspection service

“…Para Gong et al (2021), as análises sistemáticas da prevalência geral de brucelose em suínos em todo o mundo são escassas, onde realizaram uma revisão sistemática e meta-análise de Brucella spp. para analisar a prevalência combinada de brucelose em suínos e avaliar os potenciais fatores de risco associados à prevalência de brucelose, foram incluídas cinco regiões geográficas globais: África, América, Ásia, Europa e Oceania.…”