Global Burden of Urologic Cancers, 1990–2013

Dy, Geolani W.; Gore, John L.; Forouzanfar, Mohammad H.; Naghavi, Mohsen; Fitzmaurice, Christina

doi:10.1016/j.eururo.2016.10.008

Cited by 293 publications

(245 citation statements)

References 32 publications

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“…The majority of common cancers, such as bladder, breast, colon, kidney, lung, and prostate cancers occur mainly in older people [1–3]. Due to recent medical advances in treatments and diagnostic tools and the expansion of human life-span, the prevalence of cancer survivors is rapidly increasing in aging population [2, 3].…”

Section: Introductionmentioning

confidence: 99%

“…Due to recent medical advances in treatments and diagnostic tools and the expansion of human life-span, the prevalence of cancer survivors is rapidly increasing in aging population [2, 3]. It is estimated that the number of cancer survivors grows up to 19 million by 2024 in the United States and that the global cancer burden increases 50% by 2020 [1].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Rhodiola rosea L.: an Herb with Anti-Stress, Anti-Aging, and Immunostimulating Properties for Cancer Chemoprevention

Li¹,

Pham

Bui³

et al. 2017

Curr Pharmacol Rep

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Purpose of review Rhodiola rosea extracts have been used as a dietary supplement in healthy populations, including athletes, to non-specifically enhance the natural resistance of the body to both physical and behavior stresses for fighting fatigue and depression. We summarize the information with respect to the new pharmacological activities of Rhodiola rosea extracts and its underlying molecular mechanisms in this review article. Recent findings In addition to its multiplex stress-protective activity, Rhodiola rosea extracts have recently demonstrated its anti-aging, anti-inflammation, immunostimulating, DNA repair and anti-cancer effects in different model systems. Molecular mechanisms of Rhodiola rosea extracts’s action have been studied mainly along with one of its bioactive compounds, salidroside. Both Rhodiola rosea extracts and salidroside have contrast molecular mechanisms on cancer and normal physiological functions. For cancer, Rhodiola rosea extracts and salidroside inhibit the mTOR pathway and reduce angiogenesis through down-regulation of the expression of HIF-1α/HIF-2α. For normal physiological functions, Rhodiola rosea extracts and salidroside activate the mTOR pathway, stimulate paracrine function and promote neovascularization by inhibiting PHD3 and stabilizing HIF-1α proteins in skeletal muscles. In contrast to many natural compounds, salidroside is water-soluble and highly bioavailable via oral administration and concentrated in urine by kidney excretion. Summary Rhodiola rosea extracts and salidroside can impose cellular and systemic benefits similar to the effect of positive lifestyle interventions to normal physiological functions and for anti-cancer. The unique pharmacological properties of Rhodiola rosea extracts or salidroside deserve further investigation for cancer chemoprevention, in particular for human urinary bladder cancer.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Rhodiola rosea L.: an Herb with Anti-Stress, Anti-Aging, and Immunostimulating Properties for Cancer Chemoprevention

Li¹,

Pham

Bui³

et al. 2017

Curr Pharmacol Rep

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“…It is the 8 th leading cause of cancer death worldwide as developed countries are affected approximately twice more than developing countries [1]. Life expectancy in men has increase and taken into consideration the higher incidence of prostate cancer in elderly, the overall death from prostate cancer has doubled between 1990 and 2013 according to Dy et al [1].…”

Section: Letter To Editormentioning

confidence: 99%

Erectile Dysfunction: The Problem Hiding Behind Prostate Cancer

Şener¹,

Şahin²

2017

Reprod Syst Sex Disord

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“…Compared with developing countries, bladder cancer poses an increased risk to health due to its higher incidence in developed countries (2). Bladder cancer is the fifth most common type of cancer in Europe with 116,000 new cases per year (3).…”

Section: Introductionmentioning

confidence: 99%

TRAF6 expression is associated with poorer prognosis and high recurrence in urothelial bladder cancer

Hao

Cui

et al. 2017

Oncology Letters

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Abstract. The aim of the present study was to investigate the clinical significance of TNF receptor-associated factor 6 (TRAF6) expression in urothelial bladder cancer. TRAF6 expression was detected by immunohistochemistry in 126 samples of patients with urothelial bladder cancer. The association between clinicopathological factors and TRAF6 expression was analyzed by χ 2 test. The association between TRAF6 expression, overall survival rate and the recurrence-free survival rate was evaluated in univariate analysis with Kaplan-Meier test and in multivariate analysis with Cox-regression model. In the cohort tested, the rate of high TRAF6 expression was 61.9% (78/126). TRAF6 expression was demonstrated to be significantly associated with positive metastasis (P=0.001) with χ 2 test. Furthermore, TRAF6 expression was demonstrated to be associated with overall survival rate (P=0.016) and recurrence-free survival rate (P=0.016). With Cox-regression model, it was indicate that TRAF6 high expression was an independent predictive factor of poor prognosis (P=0.037) and high recurrence (P=0.011). High TRAF6 expression may predict unfavorable prognosis and high recurrence in urothelial bladder cancer, indicating that TRAF6 may be a potential and promising therapeutic target in urothelial bladder cancer.

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Global Burden of Urologic Cancers, 1990–2013

Cited by 293 publications

References 32 publications

Rhodiola rosea L.: an Herb with Anti-Stress, Anti-Aging, and Immunostimulating Properties for Cancer Chemoprevention

Rhodiola rosea L.: an Herb with Anti-Stress, Anti-Aging, and Immunostimulating Properties for Cancer Chemoprevention

Erectile Dysfunction: The Problem Hiding Behind Prostate Cancer

TRAF6 expression is associated with poorer prognosis and high recurrence in urothelial bladder cancer

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