Global assessment of the severity of epilepsy (GASE) Scale in children: Validity, reliability, responsiveness

Chan, Cindy J.; Zou, Guangyong; Wiebe, Samuel; Speechley, Kathy N.

doi:10.1111/epi.13216

Cited by 50 publications

(44 citation statements)

References 18 publications

(39 reference statements)

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“…Seizure frequency and severity are common measures of seizure burden. [10][11][12][13][14] From a treatment perspective, these are relatively clear and measurable outcomes. Our qualitative data from a sample of parents of children with severe epilepsies indicate that unpredictability is an equally important aspect of seizure burden.…”

Section: Discussionmentioning

confidence: 99%

Seizure burden in severe early‐life epilepsy: Perspectives from parents

et al. 2019

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Objectives Seizure burden is typically measured by seizure frequency yet it entails more than seizure counts, especially for people with severe epilepsies and their caregivers. We aimed to characterize the multi‐faceted nature of seizure burden in young people and their parents who are living with severe early‐life epilepsies. Methods A one‐day workshop and a series of teleconferences were held with parents of children with severe, refractory epilepsy of early‐life origin and providers for children with epilepsy. The workshop sessions were structured as focus groups and aimed to identify components of seizure burden and their impact from the perspective of parents and providers. Data were gathered, organized, and refined during the workshop using an iterative 4‐step process that drew upon grounded theory. Results Three primary components of seizure burden were identified: frequency, severity, and unpredictability, which was as important if not more important at times than frequency and severity. Caregivers noted that the impacts of seizures were experienced as acute‐immediate consequences, longer‐term consequences, and as chronic effects that develop and evolve over time. The severity of the child's neurological and medical status as well as where in the disease journey a family was represented additional contextual factors that influenced the experience of seizure burden. Significance Patient‐reported and patient‐centered outcomes are increasingly incorporated into the evaluation of treatment effectiveness. Without understanding how the disease creates burden for the patient (or family), it is difficult to know how to assess the impact of treatment. Our preliminary findings indicate seizure burden is a complex construct and unpredictability can be as important as frequency and severity.

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Section: Discussionmentioning

confidence: 99%

Seizure burden in severe early‐life epilepsy: Perspectives from parents

et al. 2019

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“…Mothers reported on their child’s age and sex, and the child’s neurologist reported the type of seizures (partial vs generalized), severity of epilepsy, and presence of behavioral, cognitive, or motor problems. Severity of epilepsy was measured using the Global Assessment of Severity of Epilepsy (GASE) scale, a single‐item, seven‐point Likert response scale . The GASE has been shown to detect within‐patient changes in severity of epilepsy and has moderate/strong correlations with several key clinical aspects of epilepsy .…”

Section: Methodsmentioning

confidence: 99%

Prevalence and trajectories of depressive symptoms among mothers of children with newly diagnosed epilepsy: A longitudinal 10‐year study

et al. 2019

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Summary Objective Parental depression significantly impacts children’s health and well‐being. This study aimed to (1) estimate the prevalence of depressive symptoms, at six time points, among mothers over the first 10 years after their child was diagnosed with epilepsy; (2) identify trajectories of maternal depressive symptoms over time; and (3) identify baseline factors associated with each trajectory. Methods Data came from the Health‐Related Quality of Life in Children with Epilepsy Study (HERQULES), a Canada‐wide prospective cohort study. Data on child, parent, and family characteristics were collected at the time of diagnosis, and follow‐ups at 0.5, 1, 2, 8, and 10 years. Maternal depressive symptoms were measured using the Center for Epidemiological Studies Depression Scale. Trajectories of depressive symptoms were evaluated using latent class growth modeling, and multinomial logistic regression was used to identify baseline factors associated with each trajectory. Results A total of 356 mothers participated in the study, of whom 57% scored in the at‐risk range for major depression disorder (period‐prevalence). Four unique trajectories were identified as follows: “Low‐Stable” (29% of mothers), “Intermediate‐Stable” (46%), “High‐Stable” (20%), and “High‐Decreasing” (5%). Positive family environment was consistently associated with a better trajectory of depressive symptoms over time; other significant factors included type of seizures, child cognitive comorbidity, maternal age, and maternal education. Significance A substantial proportion of mothers of children with epilepsy are at risk for depression, and this risk is stable over the long term. Family environment at the time of diagnosis has long‐term and persistent effects and may be an ideal target for interventions.

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“…Lower scores represented no/milder problems, and for this study, behavioral and cognitive problems were dichotomized as present or absent. In addition, neurologists provided an assessment of the overall severity of epilepsy using the Global Assessment of Severity of Epilepsy (GASE) scale . The GASE is a validated, single‐item, seven‐point Likert scale that asks, “Taking into account all aspects of this patient's epilepsy, how would you rate its severity at his/her last visit?” Response options range from 1 = extremely severe to 7 = not at all severe .…”

Section: Methodsmentioning

confidence: 99%

Measurement equivalence of the newly developed Quality of Life in Childhood Epilepsy Questionnaire (QOLCE‐55)

et al. 2016

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SUMMARYObjective: The aim of this study was to examine measurement equivalence of the newly developed Quality of Life in Childhood Epilepsy Questionnaire (QOLCE-55) across age, sex, and time in a representative sample of children with newly diagnosed epilepsy. Methods: Data come from 373 children enrolled in the Health-related Quality of Life in Children with Epilepsy Study (HERQULES), a multisite prospective cohort study. Measurement equivalence was examined using a multiple-group confirmatory factor analysis framework, whereby increasingly stringent parameter constraints are imposed on the model. Comparison groups were stratified based on age (4-7 years vs. 8-12 years), sex (male vs. female), and time (measurement of health-related quality of life at diagnosis vs. 24 months later). Significance: These findings suggest that items comprising the QOLCE-55 are perceived similarly among groups stratified by age, sex, and time and provide further evidence supporting the validity of the scale in children with epilepsy. Health professionals and researchers should be confident that group comparisons made using the QOLCE-55 are unbiased and that any group differences detected are meaningful; that is, not related to differences in the interpretation of items by informants. Future research replicating these findings is encouraged.

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Global assessment of the severity of epilepsy (GASE) Scale in children: Validity, reliability, responsiveness

Cited by 50 publications

References 18 publications

Seizure burden in severe early‐life epilepsy: Perspectives from parents

Seizure burden in severe early‐life epilepsy: Perspectives from parents

Prevalence and trajectories of depressive symptoms among mothers of children with newly diagnosed epilepsy: A longitudinal 10‐year study

Measurement equivalence of the newly developed Quality of Life in Childhood Epilepsy Questionnaire (QOLCE‐55)

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