Global Assessment of the Activity of Tigecycline against Multidrug-Resistant Gram-Negative Pathogens between 2004 and 2014 as Part of the Tigecycline Evaluation and Surveillance Trial

Abstract

Multidrug resistance among bacterial pathogens is an ongoing global problem and renders antimicrobial agents ineffective at treating bacterial infections. In the health care setting, infections caused by multidrug-resistant (MDR) Gram-negative bacteria can cause increased mortality, longer hospital stays, and higher treatments costs. The aim of the Tigecycline Evaluation and Surveillance Trial (TEST) is to assess the in vitro antimicrobial activities of tigecycline and other contemporary agents against clinically relevant pathogens. This paper presents antimicrobial activity data from the TEST study between 2004 and 2014 and examines global rates of MDR Gram-negative isolates, including Acinetobacter baumannii, Pseudomonas aeruginosa, and members of the Enterobacteriaceae, during this time. Our results show that tigecycline retained in vitro activity against many MDR Gram-negative pathogens over the study period, while rates of MDR A. baumannii increased globally. Using these findings, we hope to highlight the current status of multidrug resistance in medical facilities worldwide.

Trends in Antibiotic Resistance Among Ocular Microorganisms in the United States From 2009 to 2018

“…In addition, antibiotic resistance trends among ocular isolates were similar when evaluated by anatomical source (eg, conjunctiva, cornea, and intraocular) (eAppendix and eFigures 4-7 in the Supplement). In parallel with this finding, antibiotic resistance trends in the 10-year ARMOR data set were also similar to those reported for nonocular isolates from systemic infections in both US and global surveillance studies, such as Assessing Worldwide Antimicrobial Resistance Evaluation (AWARE), 58,71,72 Linezolid Experience and Accurate Determination of Resistance (LEADER), 73,74 Tigecycline Evaluation and Surveillance Trial (TEST), 75,76 and the SENTRY Antimicrobial Surveillance Program. 7 7-79 For instance, recent reporting for more than 190 000 S aureus isolates collected worldwide over 20 years in SENTRY demonstrated a decrease in the incidence of MRSA infection from 44.2% (2005-2008) to 39.0% (2013-2016), with the highest proportion of MRSA infection observed among patients older than 80 years; 80% of MRSA isolates were concurrently resistant to ciprofloxacin.…”

TheAcinetobactertrimeric autotransporter adhesin Ata controls key virulence traits ofAcinetobacter baumannii

“…The Gram-negative γ-proteobacterium Acinetobacter baumannii is an important pathogen in the hospital environment and causes a multitude of nosocomial infections including wound and urinary tract infections, pneumonia and bloodstream infections. The ability to acquire or upregulate antimicrobial resistance determinants has led to a high frequency of multidrugresistant A. baumannii strains worldwide [1,2]. In 2017, the World Health Organization classified carbapenemresistant A. baumannii as "priority one" on the global priority list of antibiotic-resistant, pathogenic bacteria for research and development of new antibiotics [3].…”

High nursing workload is a main associated factor of poor hand hygiene adherence in Beijing, China: An observational study

“…Hospital‐acquired infections (HAIs) are an ongoing global problem, which are mainly caused by multidrug‐resistant (MDR) Gram‐negative organisms, with a prevalence of 5% to 15% (Giammanco, Cala, Fasciana, & Dowzicky, ; Magill et al, ) in hospitalized patients. HAIs present a universal challenge for all health‐care facilities since more than 1.4 million patients in both developed and developing countries are estimated to be affected at any given time (Magill et al, ).…”