Global and Regional Left Ventricular Strain Indices in Post-Myocardial Infarction Patients with Ventricular Arrhythmias and Moderately Abnormal Ejection Fraction

Regional Longitudinal Deformation Improves Prediction of Ventricular Tachyarrhythmias in Patients With Heart Failure With Reduced Ejection Fraction

“…Indeed, recent studies have implied that assessing regional impairment or deformation may be more accurate, both for diagnostic or prognostic purposes. 9,10,[28][29][30][31][32] In the present study, we found that a decreasing longitudinal function in certain regions of the LV, determined by decreasing strain, were strong predictors of VT/VF. Impaired longitudinal deformation in these regions were a strong marker of increased risk of VT/VF, more important than a decreased global LV function (as determined by GLS or LVEF), and more important than a dyssynchronous ventricular contraction as assessed by MD.…”

“…10 Impaired deformation, as assessed by circumferential strain, in these same regions of the LV (inferior and posterior regions) have recently been demonstrated to be present significantly more frequent than impaired deformation in other regions of the LV among patients with VT/VF. 30 Therefore, regardless of the method, wall motion score index, 9 tissue Doppler imaging 10 or 2DSE, 30 impaired myocardial function of the inferioposterior region seem to confer a high risk of ventricular tachyarrhythmias. It has been hypothesized that the inferoposterior regions of the LV are innervated by greater parasympathetic (vagal) afferents, and a deceased or ailing myocardium in these regions may alter or destroy the parasympathetic Previous VT/VF, n (%) 13 (5) 15 (6) 12 (5) 28 (11) 0.017…”

Prominent differences in left ventricular performance and myocardial properties between right ventricular and left ventricular-based pacing modes in rats

“…Moreover, by using rats it should be rather straightforward to combine our model with other insults leading to myocardial dysfunction such as hypertension, diabetes mellitus, high output failure and more. Further echocardiography regional dyssynchrony assessment in parallel with ventricular arrhythmias substrate evaluation 56 , is another important future direction. In summary, our current findings support the notion that the instrumented rat model is an important new advance in this field of research and may be used to shed light on fundamental effects of dyssynchrony and resynchronization on the tissue level.…”

Risk stratification of sudden cardiac death in heart failure patients: is left ventricular ejection fraction alone sufficient?

“…Глобальный продольный стрейн (показатель деформации или относительного изменения длины сегмента миокарда) может выступать в качестве независимого фактора риска аритмических событий у пациентов с ишемией миокарда и даже использоваться для решения вопроса об имплантации КД в ранние сроки после перенесенного инфаркта миокарда (ИМ). При комбинированной оценке всех показателей двухмерной деформации чувствительность и специфичность модели в предсказании развития ЖНРС возрастает до 93% и 80%, соответственно [35].…”