Global and Regional Cerebral Blood Flow Measurements Using NMR of Injected Hyperpolarized Xenon-129

Duhamel, Guillaume; Choquet, Philippe; Grillon, Emmanuelle; Leviel, J.L.; Décorps, M.; Ziegler, Anne; Constantinesco, A.

doi:10.1016/s1076-6332(03)80275-1

Cited by 31 publications

(30 citation statements)

References 5 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…[The normal ADC value of rat brain tissue in the contralesional (left) hemisphere is (7.5±1.8)×10 -4 mm 2 /s.] Figure 3b depicts the corresponding hyperpolarized 129 Xe CSI, indicating signal reduction in large parts of the right hemisphere, consistent with the area typically experiencing decreased CBF following right MCAO in the model used (Duhamel et al, 2002). Figure 3c shows the TTC-stained brain section of the same animal as illustrated in Fig.…”

Section: Stroke Mri With Hyperpolarized 129 Xesupporting

confidence: 60%

Hyperpolarized Xenon Brain MRI

Zhou¹

2012

Advances in Brain Imaging

View full text Add to dashboard Cite

IntroductionSince hyperpolarized 129 Xe MRI was first demonstrated in the lung, air space imaging using hyperpolarized noble gases ( 129 Xe and 3 He) has progressed at a rapid rate (Goodson, 2002;Zhou, 2011c). Owing to high lipid solubility, absence of background signal in biological tissue, non-invasiveness, lack of radioactivity, different relaxation to oxygenated and deoxygenated blood, and larger chemical shift to the neighbor environment, hyperpolarized 129 Xe magnetic resonance imaging (MRI) has a great potential as a tool for studying the brain, especially for the assessment of cerebral blood flow (CBF) related to the brain function and activities.In this chapter, we will review the progress of recent research on hyperpolarized xenon brain MRI, and compare this novel technique with the conventional proton MRI in order to comment the possible innovation and development in the future. This chapter contains six main parts as follows: Properties of xenonXenon, with the chemical element symbol Xe and atomic number 54, is a member of the zero-valence elements that are called noble gases or inert gases. Xenon was discovered in the residue left over from evaporating components of liquid air by William Ramsay and Morris Travers in England in 1898, then was named by Ramsay from Greek word έ , with the meaning 'foreign' and 'strange'. Natural abundant xenon is made of nine stable isotopes, and more than 35 unstable isotopes have been characterized. Nuclei of two isotopes, 129 Xe and 131 Xe, have non-zero spin quantum number: 26.4% of 129 Xe with a nuclear spin I=1/2 ; and 21.2% of 131 Xe with a nuclear spin I=3/2 ( 133 Xe is used as a radioisotope in nuclear medicine). These two isotopes are both detectable by NMR with sensitivities of 0.021 ( 129 Xe, per nucleus relative to proton assuming thermal polarization) and 2.710 -3 ( 131 Xe). The highly enhanced signal of hyperpolarized xenon and extremely long relaxation time greatly simplified and enhanced NMR experiments, and it is the fundamental for possible biological application in MRI.Xenon, chemically inert with the external electronic orbits fully occupied, is well known as a noble gas at room temperature and an atmospheric pressure. However, the liquid and solid

show abstract

Section: Stroke Mri With Hyperpolarized 129 Xesupporting

confidence: 60%

Hyperpolarized Xenon Brain MRI

Zhou¹

2012

Advances in Brain Imaging

View full text Add to dashboard Cite

show abstract

“…In fact, several studies have already estimated cerebral blood flow from the washout kinetics of hyperpolarize 129 Xe in vivo (7)(8)(9)(10). Nevertheless, for such estimates to become quantitatively reliable, one must first understand the behavior of xenon in the brain.…”

mentioning

confidence: 99%

“…Previous in vivo investigations of hyperpolarized xenon in the rat head have failed to produce consistent spectra (3,4,(7)(8)(9)(11)(12)(13)(14)(15)(16)(17). One group obtained spectra with a single dominant peak positioned within the chemical shift range of 194 -199 ppm relative to the gas phase peak (3,4,12).…”

mentioning

confidence: 99%

“…In that study, it was suggested that the sources of the two peaks were xenon-dissolved in comparatively lipid-rich and lipid-poor brain tissue. Adding further to the confusion are the spectra obtained after intracarotid injection of xenon dissolved in a lipid emulsion (7)(8)(9)11). The spectra contained two peaks at 194.5 ppm and 199 ppm that were assigned to xenon in the emulsion and brain tissue, respectively.…”

mentioning

confidence: 99%

See 1 more Smart Citation

¹²⁹Xe spectra from the heads of rats with and without ligation of the external carotid and pterygopalatine arteries

Nakamura

Kawakami

Wakai

et al. 2005

Magnetic Resonance in Med

View full text Add to dashboard Cite

After rats inhaled hyperpolarized 129Xe gas, in vivo spectra from their heads revealed a dominant peak around 195 ppm, another easily resolvable peak near 189 ppm, a broad peak around 210 ppm, and two minor peaks around 198 ppm and 192 ppm. However, the source of each peak remains controversial. To further study the origin of each peak, we compared spectra obtained from the heads of normal rats with spectra taken from the heads of rats that had undergone ligation of the external carotid (ECA) and pterygopalatine (PPA) arteries, the major feeding vessels of nonbrain tissue in the rat head. The amplitude of the peak at around 189 ppm was greatly reduced in the ECA/PPA-ligated rats, while the peak around 195 ppm persisted. We conclude that the signal that originates from the rat brain after inhalation of 129 Xe gas is overwhelmingly dominated by the single resonance at 195 ppm. Magn Reson Med 53: 528 -534, 2005.

show abstract

“…Therefore, dissolved-phase xenon MRI and molecular imaging could provide rich information related to biological and physiological changes beyond void space lung imaging. Efforts have demonstrated the value of dissolved xenon MRI in the study of lung gas exchange (14)(15)(16), and brain perfusion (17)(18)(19)(20).…”

mentioning

confidence: 99%

Hyperpolarized xenon NMR and MRI signal amplification by gas extraction

Zhou

Graziani

Pines

2009

Proc. Natl. Acad. Sci. U.S.A.

View full text Add to dashboard Cite

A method is reported for enhancing the sensitivity of NMR of dissolved xenon by detecting the signal after extraction to the gas phase. We demonstrate hyperpolarized xenon signal amplification by gas extraction (Hyper-SAGE) in both NMR spectra and magnetic resonance images with time-of-flight information. Hyper-SAGE takes advantage of a change in physical phase to increase the density of polarized gas in the detection coil. At equilibrium, the concentration of gas-phase xenon is Ϸ10 times higher than that of the dissolved-phase gas. After extraction the xenon density can be further increased by several orders of magnitude by compression and/or liquefaction. Additionally, being a remote detection technique, the Hyper-SAGE effect is further enhanced in situations where the sample of interest would occupy only a small proportion of the traditional NMR receiver. Coupled with targeted xenon biosensors, Hyper-SAGE offers another path to highly sensitive molecular imaging of specific cell markers by detection of exhaled xenon gas.remote detection ͉ dissolved-phase xenon MRI ͉ molecular imaging ͉ phase transition

show abstract

Global and Regional Cerebral Blood Flow Measurements Using NMR of Injected Hyperpolarized Xenon-129

Cited by 31 publications

References 5 publications

Hyperpolarized Xenon Brain MRI

Hyperpolarized Xenon Brain MRI

¹²⁹Xe spectra from the heads of rats with and without ligation of the external carotid and pterygopalatine arteries

Hyperpolarized xenon NMR and MRI signal amplification by gas extraction

Contact Info

Product

Resources

About

Global and Regional Cerebral Blood Flow Measurements Using NMR of Injected Hyperpolarized Xenon-129

Cited by 31 publications

References 5 publications

Hyperpolarized Xenon Brain MRI

Hyperpolarized Xenon Brain MRI

129Xe spectra from the heads of rats with and without ligation of the external carotid and pterygopalatine arteries

Hyperpolarized xenon NMR and MRI signal amplification by gas extraction

Contact Info

Product

Resources

About

¹²⁹Xe spectra from the heads of rats with and without ligation of the external carotid and pterygopalatine arteries