Hyperpolarized xenon NMR and MRI signal amplification by gas extraction

Zhou, Xin; Graziani, Dominic; Pines, Alexander

doi:10.1073/pnas.0909147106

Cited by 48 publications

(53 citation statements)

References 32 publications

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“…By flipping data from one acquisition stage, the whole spectrum can be obtained via the concatenation of data matrices of Stages I and II as shown from Fig. 2(b) [27][28][29] Obviously, the SNR difference as a result of transversal relaxation still exists, while the overall SNRs can be improved. Figure 3 illustrates the COSY, UFCOSY, and RD-UFCOSY spectra of Sample II, which is a relatively narrow spectral width system.…”

Section: Methodsmentioning

confidence: 99%

Reverse detection for spectral width improvements in spatially encoded dimensions of ultrafast two-dimensional NMR spectra

et al. 2014

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Recently, the spatially encoded technique has been broadly used in the fast analyses of chemical systems and real-time detections of chemical reactions. In spatially encoded ultrafast 2D spectra, spectral widths and resolution in spatially encoded dimensions are contradictive, leading to the risk of insufficient spectral widths when providing satisfactory resolution values for all resonances. Here, a method named as reverse detection is proposed to improve the spectral width in the spatially encoded dimension. Experimental results show that spectral width improvements are at least twofold with reverse detection solely, and more improvements can be expected along with the gradient-controlled folding method. The proposed method can be applied to almost any spatially encoded scheme with echo planar spectroscopic imaging--like detection module and may promote wide applications of ultrafast 2D spectroscopy techniques in chemical analyses.

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Section: Methodsmentioning

confidence: 99%

Reverse detection for spectral width improvements in spatially encoded dimensions of ultrafast two-dimensional NMR spectra

et al. 2014

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“…Signal detection is performed outside the sample with a much smaller and more sensitive RF coil, with an optimized filling factor. [225] The technique requires that the encoded spins are transported to the detector before the magnetization is fully relaxed, and it inflicts one additional dimension as compared to conventional MRI, because it is based on phase encoding only. Nevertheless, it provides a substantial sensitivity boost as an ultrasensitive detection solenoid may be hundreds of times more sensitive than the encoding coil.…”

Section: Remote-detection Mri Of Hyperpolarized Gasesmentioning

confidence: 99%

NMR Hyperpolarization Techniques of Gases

Barskiy

Coffey

Nikolaou

et al. 2016

Chemistry A European J

153

117

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Nuclear spin polarization can be significantly increased through the process of hyperpolarization, leading to an increase in the sensitivity of nuclear magnetic resonance (NMR) experiments by 4–8 orders of magnitude. Hyperpolarized gases, unlike liquids and solids, can be more readily separated and purified from the compounds used to mediate the hyperpolarization processes. These pure hyperpolarized gases enabled many novel MRI applications including the visualization of void spaces, imaging of lung function, and remote detection. Additionally, hyperpolarized gases can be dissolved in liquids and can be used as sensitive molecular probes and reporters. This mini-review covers the fundamentals of the preparation of hyperpolarized gases and focuses on selected applications of interest to biomedicine and materials science.

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“…We have demonstrated the hyperpolarized xenon signal amplification by gas extraction (Hyper-SAGE) method (Zhou et al, 2009b) with enhanced NMR spectra and time-of-flight (TOF) images by using recently commercialized membrane technology for high-efficiency xenon dissolution (Baumer et.al, 2006). The Hyper-SAGE technique relies on physical amplification by exploiting a phase change and is completely distinct from chemical amplification.…”

Section: Outlook Of Hyperpolarized 129 Xe Brain Mrimentioning

confidence: 99%

Hyperpolarized Xenon Brain MRI

Zhou¹

2012

Advances in Brain Imaging

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IntroductionSince hyperpolarized 129 Xe MRI was first demonstrated in the lung, air space imaging using hyperpolarized noble gases ( 129 Xe and 3 He) has progressed at a rapid rate (Goodson, 2002;Zhou, 2011c). Owing to high lipid solubility, absence of background signal in biological tissue, non-invasiveness, lack of radioactivity, different relaxation to oxygenated and deoxygenated blood, and larger chemical shift to the neighbor environment, hyperpolarized 129 Xe magnetic resonance imaging (MRI) has a great potential as a tool for studying the brain, especially for the assessment of cerebral blood flow (CBF) related to the brain function and activities.In this chapter, we will review the progress of recent research on hyperpolarized xenon brain MRI, and compare this novel technique with the conventional proton MRI in order to comment the possible innovation and development in the future. This chapter contains six main parts as follows: Properties of xenonXenon, with the chemical element symbol Xe and atomic number 54, is a member of the zero-valence elements that are called noble gases or inert gases. Xenon was discovered in the residue left over from evaporating components of liquid air by William Ramsay and Morris Travers in England in 1898, then was named by Ramsay from Greek word έ , with the meaning 'foreign' and 'strange'. Natural abundant xenon is made of nine stable isotopes, and more than 35 unstable isotopes have been characterized. Nuclei of two isotopes, 129 Xe and 131 Xe, have non-zero spin quantum number: 26.4% of 129 Xe with a nuclear spin I=1/2 ; and 21.2% of 131 Xe with a nuclear spin I=3/2 ( 133 Xe is used as a radioisotope in nuclear medicine). These two isotopes are both detectable by NMR with sensitivities of 0.021 ( 129 Xe, per nucleus relative to proton assuming thermal polarization) and 2.710 -3 ( 131 Xe). The highly enhanced signal of hyperpolarized xenon and extremely long relaxation time greatly simplified and enhanced NMR experiments, and it is the fundamental for possible biological application in MRI.Xenon, chemically inert with the external electronic orbits fully occupied, is well known as a noble gas at room temperature and an atmospheric pressure. However, the liquid and solid

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Hyperpolarized xenon NMR and MRI signal amplification by gas extraction

Cited by 48 publications

References 32 publications

Reverse detection for spectral width improvements in spatially encoded dimensions of ultrafast two-dimensional NMR spectra

Reverse detection for spectral width improvements in spatially encoded dimensions of ultrafast two-dimensional NMR spectra

NMR Hyperpolarization Techniques of Gases

Hyperpolarized Xenon Brain MRI

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