Global Allergy Forum and Second Davos Declaration 2013 Allergy: Barriers to cure - challenges and actions to be taken

Ring, Johannes; Akdiş, Cezmi A.; Lauener, Roger; Schäppi, Georg; Traidl‐Hoffmann, Claudia; Akdiş, Mübeccel; Ammann, Walter; Behrendt, Heidrun; Bieber, Thomas; Biedermann, Tilo; Bienenstock, John; Blaser, Kurt; Braun-Fahrländer, C; Brockow, Knut; Buters, Jeroen; Crameri, Reto; Darsow, Ulf; Denburg, JA; Eyerich, Kilian; Frei, Remo; Galli, Stephen J.; Gutermuth, Jan; Holt, Patrick G.; Koren, Hillel S.; Leung, Donald Y.M.; Müller, Ulrich; Muraro, Antonella; Ollert, Markus; O’Mahony, Liam; Pawankar, Ruby; Platts-Mills, Thomas A.E.; Rhyner, Claudio; Rosenwasser, Lanny J.; Schmid‐Grendelmeier, Peter; Schmidt‐Weber, Carsten B.; Schmutz, W.; Simon, Dagmar; Simon, Hans‐Uwe; Sofiev, M.; Hage, Marianne van; Ree, Ronald van

doi:10.1111/all.12406

Cited by 31 publications

(25 citation statements)

References 12 publications

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“…In addition, transendothelial migration of inflammatory cells and their activation within the reactive tissue are characteristic features, which represent the result of a complex network of interactions between various mediators, cytokines, chemokines, and adhesion molecules. However, our understanding of the disease origin and development of truly curative therapies have proved to be challenging and elusive goals [31].…”

Section: Allergic Rhinitismentioning

confidence: 99%

Upper Airway Stem Cells: Understanding the Nose and Role for Future Cell Therapy

Wang

Yan

et al. 2014

Curr Allergy Asthma Rep

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The nose together with the paranasal sinuses has an approximate surface area of 100 to 200 cm(2) in adults, which is lined with pseudostratified columnar ciliated epithelium. It serves several important physiological functions such as conditioning and filtration of the inspired air and the provision of end organ for the sense of smell. It is also a physical and immunological barrier as it is the first site of interaction between the host tissue and foreign invaders (viruses, bacteria, and allergens). Our understanding of the complex cellular events occurring in response to inhaled agents during the development of common airway diseases has been significantly enhanced by the current status of in vivo and in vitro nasal experimental models. This will allow the development of novel therapeutic strategies designed to improve the physiological and immune defense functions of the nasal epithelium, as well as novel therapies for other common nasal diseases.

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Section: Allergic Rhinitismentioning

confidence: 99%

Upper Airway Stem Cells: Understanding the Nose and Role for Future Cell Therapy

Wang

Yan

et al. 2014

Curr Allergy Asthma Rep

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“…On the basis of the high and increasing prevalence of allergic diseases [14, 15] (at the moment 28.1% in adults in Germany [16]), there is a public health relevance to further investigate the associations between psychosocial factors and allergies. The investigation of associations between psychosocial factors and allergies as well as the finding of underlying molecular mechanisms with potential therapy options might not only help to improve the quality of life of the respective patients.…”

Section: Introductionmentioning

confidence: 99%

Different Psychosocial Factors Are Associated with Seasonal and Perennial Allergies in Adults: Cross-Sectional Results of the KORA FF4 Study

Harter¹,

Hammel²,

Krabiell

et al. 2019

Int Arch Allergy Immunol

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Background: Psychosocial factors are supposed to play a central role in the development of allergic diseases. Associations with seasonal and perennial forms of allergies have not been investigated, yet. Objectives: The aim of the study was to investigate the associations of psychosocial factors (social status, depression, generalized anxiety, psychosocial stress, Type-D personality) with seasonal, perennial, and other forms of allergies in adults. Method: The analysis of self-reported data of the KORA FF4 study was performed with SAS 9.4. The sample consisted of 1,782 study participants in the study region of Augsburg (39–88 years, 61 years, 51.1% female). Descriptive bivariate statistics and multinomial logistic regression models were performed. Age, sex, family predisposition, and smoking status were considered possible confounders. Moreover, several sensitivity analyses were carried out to check whether missing values distorted the results. Results: A positive association between generalized anxiety and seasonal allergies was found in the multivariate model. Depression was positively, and anxiety negatively, associated with perennial allergies. No association between the analyzed psychosocial factors and other forms of allergies could be found. Conclusion: The results support the relevance of psychosocial factors in association with allergies. Looking at the psychosocial factors, a separate consideration of seasonal and perennial allergies seems reasonable. Further longitudinal studies should investigate the direction of the associations, the underlying mechanisms, and other psychosocial factors, such as coping mechanisms, in confirmed allergies.

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“…It is therefore of utmost importance that the progress achieved in basic and clinical science becomes translated in political actions and in practical applications. The outstanding progress obtained during the few past years and the limited financial resources ask for a large discussion and definition of the future needs in appropriate forums . A tremendous work has been carried out by the EAACI during the past years to define needs and guidelines for prevention , management , and treatment of allergic disease .…”

Section: Future Perspectives and Conclusionmentioning

confidence: 99%

The contribution of biotechnology toward progress in diagnosis, management, and treatment of allergic diseases

Palomares

Crameri

Rhyner

2014

Allergy

Self Cite

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Abstract'Biotechnology' has been intuitively used by humans since thousands of years for the production of foods, beverages, and drugs based on the experience without any scientific background. However, the golden era of this discipline emerged only during the second half of the last century. Incredible progresses have been achieved on all fields starting from the industrialization of the production of foods to the discovery of antibiotics, the decipherment of the genetic code, and rational approaches to understand and define the status we now call 'healthy'. The extremely complex interactions between genetic background, life style, and environmental factors influencing our continuously increasing life span have become more and more evident and steadily generate new questions which are only partly answered. Here, we try to summarize the contribution of biotechnology to our understanding, control, and cure of IgE-mediated allergic diseases. We are aware that a review of such a vast topic can never cover all aspects of the progress achieved in the different fields.

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Global Allergy Forum and Second Davos Declaration 2013 Allergy: Barriers to cure - challenges and actions to be taken

Cited by 31 publications

References 12 publications

Upper Airway Stem Cells: Understanding the Nose and Role for Future Cell Therapy

Upper Airway Stem Cells: Understanding the Nose and Role for Future Cell Therapy

Different Psychosocial Factors Are Associated with Seasonal and Perennial Allergies in Adults: Cross-Sectional Results of the KORA FF4 Study

The contribution of biotechnology toward progress in diagnosis, management, and treatment of allergic diseases

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