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Penel, Guillaume; Leroy, G.; Rey, Christian; Sombret, B.; Huvenne, J.P.; Brès, E.

doi:10.1023/a:1018504126866

Cited by 160 publications

(82 citation statements)

References 5 publications

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“…Powder measurements with classical FTIR displayed absorption peaks at 1038, 1067, 1097 cm −1 for fluorapatite, and at 1034, 1053, 1105 cm −1 for hydroxyapatite, where indeed the last two peaks were found to be strongly split by the nonspherical shape of the particles [52]. Similar values were reported in other studies [24,53,54]. As the mineral in dentin and bone consists of isolated, locally ordered apatite platelets, strong depolarization effects probably distort the infrared spectra in the ν 3 phosphate resonance region.…”

Section: Discussionsupporting

confidence: 86%

Nano-FTIR chemical mapping of minerals in biological materials

et al. 2012

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Methods for imaging of nanocomposites based on X-ray, electron, tunneling or force microscopy provide information about the shapes of nanoparticles; however, all of these methods fail on chemical recognition. Neither do they allow local identification of mineral type. We demonstrate that infrared near-field microscopy solves these requirements at 20 nm spatial resolution, highlighting, in its first application to natural nanostructures, the mineral particles in shell and bone. "Nano-FTIR" spectral images result from Fourier-transform infrared (FTIR) spectroscopy combined with scattering scanning near-field optical microscopy (s-SNOM). On polished sections of Mytilus edulis shells we observe a reproducible vibrational (phonon) resonance within all biocalcite microcrystals, and distinctly different spectra on bioaragonite. Surprisingly, we discover sparse, previously unknown, 20 nm thin nanoparticles with distinctly different spectra that are characteristic of crystalline phosphate. Multicomponent phosphate bands are observed on human tooth sections. These spectra vary characteristically near tubuli in dentin, proving a chemical or structural variation of the apatite nanocrystals. The infrared band strength correlates with the mineral density determined by electron microscopy. Since nano-FTIR sensitively responds to structural disorder it is well suited for the study of biomineral formation and aging. Generally, nano-FTIR is suitable for the analysis and identification of composite materials in any discipline, from testing during nanofabrication to even the clinical investigation of osteopathies.

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Section: Discussionsupporting

confidence: 86%

Nano-FTIR chemical mapping of minerals in biological materials

et al. 2012

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“…3 and was found to be that of hydroxyapatite (stoichiometric formula (Ca 10 (PO 4 ) 6 (OH) 2 ) (see e.g. [11,12]). It contains two relatively strong bands at 952 cm −1 (PO 4 ν 1 vibration) and 1076 cm −1 (PO 4 ν 3 vibration) and two phosphate bands in the range 400 to 500 cm −1 (due to ν 2 ) and 550 to 650 cm −1 (ν 4 ).…”

Section: Resultsmentioning

confidence: 99%

Bioactive Glass Coatings Synthesized by Pulsed Laser Deposition Technique

2012

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Surface modification of medical implants is often required to improve their biocompatibility or, through bioactive properties of the surface material, facilitate its intergrowth with the living tissue. Bioactive-glass coatings can serve that purpose for the bone implants. We report a successful preparation of silicate-phosphate bioactive-glass coating on titanium substrate using the pulsed laser deposition method and present the coating characterization in terms of bonding configuration and chemical activity. The former was studied with high-resolution Raman microspectroscopy and revealed the presence of structural units responsible for the material's bioactivity. The bioactivity was also tested directly, in vitro, by soaking the samples in the simulated body fluid and examining the result with the Raman spectroscopy. The Raman spectrum, typical of hydroxyapatite was observed proving that the bone-like-material formed on the coating's surface.

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“…The peak at 570 cm -1 indicates the formation of an amorphous calcium phosphate layer. This peak splits into two peaks at 613 cm -1 and 574 cm -1 , thus indicating formation of an apatite crystalline phase [57][58] . After 1 week in SBF only the 0Co BG shows the presence of crystalline HCA (Fig.…”

Section: Bioactivity Of and Hca Formation On The Bioactive Glassesmentioning

confidence: 99%

Synthesis and characterization of hypoxia-mimicking bioactive glasses for skeletal regeneration

et al. 2010

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The cellular response to hypoxia is vital for skeletal tissue development and regeneration. Numerous processes, including progenitor cell recruitment, proliferation and differentiation, are activated through the hypoxia pathway in a low oxygen pressure environment. Novel materials-based strategies designed to activate the hypoxia pathway are therefore of great interest for orthopaedic tissue engineering.Here resorbable bioactive glasses (BG) were designed to activate the hypoxia pathway by substitution of Co 2+ for Ca 2+ in the BG and substitution of Co 2+ and Ca 2+ /+2Na + for Si 4+ . This allowed for the controlled release of cobalt, whilst controlling BG bioactivity (apatite-forming ability). Two series of soda-lime-phosphosilicate glasses were manufactured with increasing concentrations of cobalt. Compositions were calculated to maintain constant network connectivity (2.13) by considering cobalt as an intermediate oxide in the first series, and as a network modifier in the second series. Mg 2+ and Zn 2+ were added to one of the Co 2+ -containing glasses to inhibit HCA formation since delay or inhibition of HCA formation is essential for the use of BG in soft tissues, as is the case of cartilage.Cobalt was present in both the silicate and phosphate phases of the BG. In addition, evidence was found for it playing a dual role in the silicate phase, acting as both an intermediate oxide and taking part in the network as well as being a network modifying oxide. Consistent with an intermediate oxide role, the presence of cobalt in the BG was shown to decrease ion release. HCA formation was delayed with cobalt additions. Mg 2+ and Zn 2+ further delayed HCA formation.Cobalt release was found to be proportional to cobalt content of the BGs enabling the controlled delivery of cobalt in therapeutic active doses.

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Cited by 160 publications

References 5 publications

Nano-FTIR chemical mapping of minerals in biological materials

Nano-FTIR chemical mapping of minerals in biological materials

Bioactive Glass Coatings Synthesized by Pulsed Laser Deposition Technique

Synthesis and characterization of hypoxia-mimicking bioactive glasses for skeletal regeneration

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