Glistening Formation and Light Scattering in Six Hydrophobic-Acrylic Intraocular Lenses

Łabuz, Grzegorz; Knebel, Dominik; Auffarth, Gerd U.; Fang, Hui; Berg, Thomas J. van den; Yildirim, Timur M.; Son, Hyeck-Soo; Khoramnia, Ramin

doi:10.1016/j.ajo.2018.08.032

Cited by 62 publications

(86 citation statements)

References 43 publications

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“…Despite these benefits, hydrophobic acrylic IOLs are prone to develop glistenings. This long-term change in the material can worsen the lens' optical performance [8,9]. In recent research, our group has examined the nature of this deterioration in vision that is attributable to glistenings.…”

Section: Discussionmentioning

confidence: 99%

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Glistening formation in a new hydrophobic acrylic intraocular lens

et al. 2020

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Background: The formation of fluid-filled microvacuoles, termed glistenings, is a common complication of intraocular lenses (IOLs) made from hydrophobic acrylate. Using our well-established in-vitro laboratory method, we evaluated a new IOL material's resistance to glistening formation. Methods: An in-vitro stress test for glistening induction was performed on 20 samples of hydrophobic acrylic IOLs: ten of the new Eyecryl ASHFY600 (Biotech Vision Care, Ahmedabad, India) compared with ten samples of AcrySof IQ SN60WF (Alcon, Fort Worth, USA). The number of microvacuoles per square millimetre (MV/mm 2) was evaluated in five sections of each IOL. The results for each model were compared and rated on a modified Miyata Scale for grading glistening severity. Results: In all cases, glistening number was higher in the central section of the IOL optic than in the periphery. Mean number of MV/mm 2 was highest in the central part of the AcrySof IQ SN60WF, with 41.84 (±27.67) MVs/mm 2. The lowest number of glistenings was found in the five sections of the Eyecryl ASHFY600 with 0.52 (±0.24) MVs/ mm 2. Mean value of the Eyecryl ASHFY600 IOL, using the Miyata Scale, was Zero. Conclusion: In this in-vitro laboratory study, the new hydrophobic acrylic IOL showed a high resistance to microvacuole formation. Results from this in-vitro study suggest that glistening numbers will be low in clinical use in the Eyecryl ASHFY600.

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Section: Discussionmentioning

confidence: 99%

“…Using such methods, the impact of glistenings on the optical performance has been studied and is now well understood. Glistenings have a rather small effect on the central image quality; their impact on light scattering, on the other hand, is greater [8,9].…”

Section: Introductionmentioning

confidence: 98%

Glistening formation in a new hydrophobic acrylic intraocular lens

et al. 2020

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“…This long-term change in the material can worsen the lens' optical performance. [8,9] In recent research, our group has examined the nature of this deterioration in vision that is attributable to glistenings. Our with those made in 2012.…”

Section: Discussionmentioning

confidence: 99%

“…Glistenings have a rather small effect on the central image quality; their impact on light scattering, on the other hand, is greater. [8,9] We evaluated, using an established in vitro laboratory method, the formation of glistenings of a new hydrophobic IOL, one which the manufacturer claims is more resistant to glistening formation: the Eyecryl Plus ASHFY600, and compared it to the well-established and accepted AcrySof IQ SN60WF.…”

Section: Introductionmentioning

confidence: 99%

Glistening formation in a new hydrophobic acrylic intraocular lens

Yildirim

Fang

Schickhardt

et al. 2020

Preprint

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Background: The formation of fluid-filled microvacuoles, termed glistenings, is a common complication of intraocular lenses (IOLs) made from hydrophobic acrylate. Using our well-established in-vitro laboratory method, we evaluated a new IOL material’s resistance to glistening formation.Methods: An in-vitro stress test for glistening induction was performed on twenty samples of hydrophobic acrylic IOLs: ten of the new Eyecryl ASHFY600 (Biotech Vision Care, Ahmedabad, India) compared with ten samples of AcrySof IQ SN60WF (Alcon, Fort Worth, USA). The number of microvacuoles per square millimetre (MV/mm2) was evaluated in five sections of each IOL. The results for each model were compared and rated on the Miyata Scale for grading glistening severity.Results: In all cases, glistening number was higher in the central section of the IOL optic than in the periphery. Mean number of MV/mm2 was highest in the central part of the AcrySof IQ SN60WF, with 41.84 (±27.67) MVs/mm². The lowest number of glistenings was found in the five sections of the Eyecryl ASHFY600 with 0.52 (±0.24) MVs/mm². Mean value of the Eyecryl ASHFY600 IOL, using the Miyata Scale, was Zero.Conclusion: In this in-vitro laboratory study, the new hydrophobic acrylic IOL showed a high resistance to microvacuole formation. Results from this in-vitro study suggest that glistening numbers will be low in clinical use in the Eyecryl ASHFY600.

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“…Glistenings have a rather small effect on the central image quality; their impact on light scattering, on the other hand, is greater. [8,9] We evaluated, using an established in vitro laboratory method, the material quality and stability of a new hydrophobic IOL, one which the manufacturer claims is more resistant to glistenings formation:…”

Section: Introductionmentioning

confidence: 99%

The material quality of a new hydrophobic acrylic intraocular lens

Yildirim

Fang

Schickhardt

et al. 2019

Preprint

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Background The formation of fluid-filled microvacuoles, termed glistenings, is a common complication of intraocular lenses (IOLs) made from hydrophobic acrylate. Using our well established in-vitro laboratory method, we evaluated a new IOL material’s resistance to glistenings formation. Methods An in-vitro stress test for glistenings induction was performed on twenty samples of hydrophobic acrylic IOLs: ten of the new Eyecryl ASHFY600 (Biotech Vision Care, Ahmedabad, India) compared with ten samples of AcrySof IQ SN60WF (Alcon, Fort Worth, USA). The number of microvacuoles per square millimetre (MV/mm 2 ) was evaluated in five sections of each IOL. The results for each model were compared and rated on the Miyata Scale for grading glistening severity. Results In all cases, glistenings number was higher in the central section of the IOL optic than in the periphery. Mean number of MV/mm 2 was highest in the central part of the AcrySof IQ SN60WF, with 41.84 (±27.67) MVs/mm 2 . The lowest number of glistenings was found in the five sections of the Eyecryl ASHFY600 with 0.52 (±0.24) MVs/mm 2 . Mean value of the Eyecryl ASHFY600 IOL, using the Miyata Scale, was Zero. Conclusion In this in-vitro laboratory study, the new hydrophobic acrylic IOL showed a high resistance to microvacuole formation. In clinical use, one can confidently expect glistenings numbers will be low and clinically irrelevant in the Eyecryl ASHFY600.

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Glistening Formation and Light Scattering in Six Hydrophobic-Acrylic Intraocular Lenses

Cited by 62 publications

References 43 publications

Glistening formation in a new hydrophobic acrylic intraocular lens

Glistening formation in a new hydrophobic acrylic intraocular lens

Glistening formation in a new hydrophobic acrylic intraocular lens

The material quality of a new hydrophobic acrylic intraocular lens

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