Glioblastoma multiforme in children: experience at Hospital Infantil de Mexico Federico Gomez

Sánchez-Herrera, Federico; Castro-Sierra, Eduardo; Gordillo-Domínguez, Luis Felipe; Vaca-Ruiz, Miguel Angel; Santana-Montero, Blanca Lilia; Pérezpeña-Díazconti, Mario; González-Carranza, Vicente; Torres-García, Samuel; León, Fernando Chico-Ponce de

doi:10.1007/s00381-008-0780-8

Cited by 29 publications

(17 citation statements)

References 18 publications

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“…In intracranial GBM, the mean age at presentation was 8.8-13 years in the literature. 35,47 The present study showed the mean age at presentation for primary spinal GBM was 10 ± 5.1 years. For intracranial GBM, studies have shown a male predominance.…”

Section: Discussionmentioning

confidence: 48%

A systematic review of overall survival in pediatric primary glioblastoma multiforme of the spinal cord

Konar

Bir

Maiti

et al. 2017

PED

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OBJECTIVE The incidence of primary spinal cord glioblastoma multiforme (GBM) in the pediatric age group is very rare. Only a few case series and case reports have been published in the literature; therefore, overall survival (OS) outcome and the as-yet poorly defined management options are not discussed in detail. The authors performed a cumulative survival analysis of all reported cases of pediatric spinal cord GBM to identify the predictive factors related to final survival outcome. METHODS A comprehensive search for relevant articles was performed on PubMed's electronic database MEDLINE for the period from 1950 to 2015 using the search words “malignant spinal cord tumor” and “spinal glioblastoma multiforme.” This study was limited to patients younger than 18 years of age. Survival rates for children with various tumor locations and treatments were collected from the published articles and analyzed. RESULTS After an extensive literature search, 29 articles met the study inclusion criteria. From the detailed information in these articles, the authors found 53 children eligible for the survival analysis. The majority (45%) of the children were more than 12 years old. Thirty-four percent of the cases were between 7 and 12 years of age, and 21% were younger than 7 years. In the Kaplan-Meier survival analysis, children younger than 7 years of age had better survival (13 months) than the children older than 7 years (7–12 years: 10 months, > 12 years: 9 months; p = 0.01, log-rank test). Fifty-five percent of the children were female and 45% were male. A cervical tumor location (32%) was the most common, followed by thoracic (28.3%). Cervicothoracic (18.9%) and conus (18.8%) tumor locations shared the same percentage of cases. Cervical tumors had a worse outcome than tumors in other locations (p = 0.003, log-rank test). The most common presenting symptom was limb weakness (53%), followed by sensory disturbances (25%). Median OS was 10 months. The addition of adjuvant therapy (radiotherapy [RT] and/or chemotherapy [CT]) after surgery significantly improved OS (p = 0.01, log-rank test). Children who underwent gross-total resection and RT had better outcomes than those who underwent subtotal resection and RT (p = 0.04, log-rank test). Cerebrospinal fluid spread, hydrocephalus, brain metastasis, and spinal metastasis were not correlated with OS in primary spinal GBM. CONCLUSIONS Adjuvant therapy after surgery had a beneficial effect on overall outcome of spinal GBM in the pediatric age group. Gross-total resection followed by RT produced a better outcome than subtotal resection with RT. Further large-scale prospective study is required to establish the genetic and molecular factors related to OS in primary GBM of the spinal cord in pediatric patients.

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Section: Discussionmentioning

confidence: 48%

A systematic review of overall survival in pediatric primary glioblastoma multiforme of the spinal cord

Konar

Bir

Maiti

et al. 2017

PED

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“…In contrast, GBM accounts for no more than 3-15% of primary central nervous system (CNS) tumors in children (2)(3)(4)(5)(6)(7). This is despite the fact that CNS tumors are the most common solid tumors of childhood, and 40-50% of these tumors are constituted by the astrocytomas (8).…”

Section: Introductionmentioning

confidence: 81%

Pediatric Glioblastoma

Das¹,

Kumar²

2017

Glioblastoma

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Glioblastoma in children, when compared with adults, is relatively rare. Despite this rarity, it is apparent from the limited number of publications that pediatric glioblastoma is quite distinct from their adult counterparts. The differences pertain to the molecular genetics, effectiveness of the adjuvant therapies, and possibly the prognosis after treatment. With a plethora of path-breaking translational research coming through in recent times, a host of new information is now available on pediatric glioblastomas that holds great promise as far as the future treatment options are concerned. This chapter is an attempt to highlight the key clinical aspects of pediatric glioblastoma in the light of the emerging clinical and laboratory evidence.

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“…[9] However, secondary GBMs arise from other astrocytomas after years. [10] There are reports from other centers on pediatric GBM [Table 3]. We studied GBM in young age (20 years or less) during 18 years from 1990 to 2008.…”

Section: Discussionmentioning

confidence: 99%

Pediatric glioblastoma multiforme: A single-institution experience

Ansari

Nasrolahi

Kani

et al. 2012

Indian Journal of Medical and Paediatric Oncology

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Background:Glioblastoma multiforme (GBM) is the most common astrocytoma in adults and has a poor prognosis, with a median survival of about 12 months. But, it is rare in children. We report our experience on the pediatric population (20 years or younger) with GBM.Patients and Methods:Twenty-three patients with GBM who were treated at our hospital during 1990–2008 were evaluated.Results:The mean age was 15.2 years, and the majority of them (14/23) were male. All had received radiotherapy and some had also received chemotherapy. The mean survival was 16.0 months. Two cases survived more than 5 years. Age, radiation dose and performance status were significantly related to survival.Conclusion:GBM in pediatric patients were not very common in our center, and prognosis was unfavorable.

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Glioblastoma multiforme in children: experience at Hospital Infantil de Mexico Federico Gomez

Cited by 29 publications

References 18 publications

A systematic review of overall survival in pediatric primary glioblastoma multiforme of the spinal cord

A systematic review of overall survival in pediatric primary glioblastoma multiforme of the spinal cord

Pediatric Glioblastoma

Pediatric glioblastoma multiforme: A single-institution experience

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