Glimepiride reduces mononuclear activation of the redox‐sensitive transcription factor nuclear factor‐kappa B

Abstract

Glimepiride can affect the activation of the redox-sensitive transcription factor NF-kappaB in vitro and in vivo.

Glimepiride as insulin sensitizer: increased liver and muscle responses to insulin

“…As a lipophilic molecule, glimepiride is able to intercalate the lipid bilayer of cells and to modulate steps of the insulin-signalling cascade [4]. Additionally, glimepiride can reduce the nuclear factor kB activity [11], which has been reported to correlate with increased GLUT4 expression [12]. These mechanisms could be involved, in a tissue-specific way, in the improvement of insulin sensitivity observed.…”

Reduction of Postprandial Hyperglycemia in Patients with Type 2 Diabetes Reduces NF-κB Activation in PBMCs

“…Peripheral blood mononuclear cells (PBMC) were separated immediately after venipuncture as previously described in detail [38,41]. 10 ml whole blood anticoagulated with 3,8 % sodium citrate (9 : 1; vol/vol) was loaded carefully onto Ficoll Paque Plus gradient (Pharmacia, Freiburg, Germany) and centrifuged for 30 min at 500 g without brakes at 4 8C.…”

Reduced Cell Proliferation and Neuroblast Differentiation in the Dentate Gyrus of High Fat Diet-Fed Mice are Ameliorated by Metformin and Glimepiride Treatment

“…In addition, glimepiride is a sulfonylurea that stimulates the release of insulin from pancreatic beta cells and induces the increased activity of intracellular insulin receptors [18]. Glimepiride may offer some advantages when used in combination with metformin due to its more prominent extrapancreatic activity and more favorable safety profile compared with other sulfonylureas [18][19][20][21]. Some pharmacy sells metformin-glimepiride tablets, which resulted in significantly greater reductions in glycated hemoglobin (HbA1c) and fasting plasma glucose compared with metformin ?…”