Gliclazide alone or in combination with atorvastatin ameliorated reproductive damage in streptozotocin-induced type 2 diabetic male rats

Öztaş, Ezgi; Yılmaz, Tuğba Ekiz; Güzel, Elif; Sezer, Zehra; Özhan, Gül

doi:10.1016/j.jsps.2019.01.003

Cited by 10 publications

(4 citation statements)

References 44 publications

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“…A case report of a 35-year-old man with primary infertility, a slight increase in glucose levels and overweight showed a deleterious effect of liraglutide on male reproductive function [ 110 ]. On the other hand, some authors [ 111 ] reported that gliclazide, alone or in combination with atorvastatin, ameliorated reproductive damage in streptozotocin-induced type 2 diabetic male rats.…”

Section: Treatment Of Mets and Its Impact On Semen Qualitymentioning

confidence: 99%

Metabolic Syndrome and Reproduction

Lotti

Marchiani

Corona

et al. 2021

IJMS

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Metabolic syndrome (MetS) and infertility are two afflictions with a high prevalence in the general population. MetS is a global health problem increasing worldwide, while infertility affects up to 12% of men. Despite the high prevalence of these conditions, the possible impact of MetS on male fertility has been investigated by a few authors only in the last decade. In addition, underlying mechanism(s) connecting the two conditions have been investigated in few preclinical studies. The aim of this review is to summarize and critically discuss available clinical and preclinical studies on the role of MetS (and its treatment) in male fertility. An extensive Medline search was performed identifying studies in the English language. While several studies support an association between MetS and hypogonadism, contrasting results have been reported on the relationship between MetS and semen parameters/male infertility, and the available studies considered heterogeneous MetS definitions and populations. So far, only two meta-analyses in clinical and preclinical studies, respectively, evaluated this topic, reporting a negative association between MetS and sperm parameters, testosterone and FSH levels, advocating, however, larger prospective investigations. In conclusion, a possible negative impact of MetS on male reproductive potential was reported; however, larger studies are needed.

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Section: Treatment Of Mets and Its Impact On Semen Qualitymentioning

confidence: 99%

Metabolic Syndrome and Reproduction

Lotti

Marchiani

Corona

et al. 2021

IJMS

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“…In recent years, several therapeutic interventions have been explored in rats to target different molecular pathways involved in diabetic-induced male testicular dysfunction. A marked structural and functional impairment of reproductive function in diabetic rats has been reported ( Mao et al, 2018 ; Barsiah et al, 2019 ; Öztaş et al, 2019 ). In the testis, a significant disruption of seminiferous tubular architecture with decreased spermatic content and atrophied germinal epithelium and interstitial tissue was noticed ( Mao et al, 2018 ; Barsiah et al, 2019 ; Öztaş et al, 2019 ).…”

Section: Discussionmentioning

confidence: 99%

“…A marked structural and functional impairment of reproductive function in diabetic rats has been reported ( Mao et al, 2018 ; Barsiah et al, 2019 ; Öztaş et al, 2019 ). In the testis, a significant disruption of seminiferous tubular architecture with decreased spermatic content and atrophied germinal epithelium and interstitial tissue was noticed ( Mao et al, 2018 ; Barsiah et al, 2019 ; Öztaş et al, 2019 ). These changes are secondary to chronic metabolic complications of diabetes including chronic hyperglycemia, insulin resistance, and dyslipidemia which initiate an inflammatory response as demonstrated by positive testicular immune staining for TNFα and a significant increase in serum TNFα and IL6 ( Kwon and Pessin, 2013 ; Long et al, 2018 ; Barsiah et al, 2019 ).…”

Section: Discussionmentioning

confidence: 99%

Liraglutide ameliorates diabetic-induced testicular dysfunction in male rats: role of GLP-1/Kiss1/GnRH and TGF-β/Smad signaling pathways

et al. 2023

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Introduction: Glucagon-like peptide -1 (GLP-1) is released by intestinal cells to stimulate glucose-dependent insulin release from the pancreas. GLP-1 has been linked to ameliorating obesity and/or diabetic complications as well as controlling reproductive function. Liraglutide is a GLP-1 receptor agonist (GLP-1RA) with 97% homology with GLP-1. The main objective of this study was to investigate the ameliorative role of liraglutide in diabetic-induced reproductive dysfunction in male rats.Methods: Rats were randomly allocated into 3 groups; a control group, a diabetic group, and a liraglutide-treated diabetic group.Results: In the diabetic group, a significant increase in BMI, FBG, HbA1c, HOMA-IR, TC, TAG, LDL, IL6, TNFα, and MDA, as well as decreased serum insulin, HDL, GSH, total testosterone, LH, and FSH, were shown compared to the control group. Furthermore, A significant downregulation in relative hypothalamic gene expression of GLP-1R, PPAR-α, PGC-1α, kiss, kiss1R, leptin, leptin R, GnRH GLP-1R, testicular PGC-1α, PPARα, kiss1, kiss1R, STAR, CYP17A1, HSD17B3, CYP19A, CYP11A1, and Smad7, as well as upregulation in hypothalamic GnIH and testicular TGF- β and Smad2 expression, were noticed compared to the control group. Liraglutide treatment significantly improved such functional and structural reproductive disturbance in diabetic rats.Conclusion: GLP-1RAs ameliorated the deleterious effects of diabetes on reproductive function by targeting GLP-1/leptin/kiss1/GnRH, steroidogenesis, and TGF- β/Smad pathways.

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“…Ma le reproduc t ive f unc t ion is compromised by diabetes mellitus, a major global health concern nowadays. [1,2] Hyperglycemia-induced massive generation of mitochondrial oxygen species of high reactivity (OSHR) can bring several difficulties in different organs, including testis. [3] Reports have demonstrated that chronic hyperglycemia results in alteration of androgenesis, damage of testicular tissue, and impairment of spermatogenesis that ultimately induces male subfertility.…”

Section: Introductionmentioning

confidence: 99%

Amelioration of Diabetes Associated Hypo-testicular Co-morbidities in Rat by <i>Aloe vera</i> (L.): Potent Extract Selection Study

Pal,

Lohar,

Mondal

et al. 2024

Int. J. Pharm. Sci. Drug Res.

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The present experiment was conducted to get the most effective extract of Aloe vera (L.) leaf gel for the correction of testicular hypo-function in diabetic rat. A single-time injection (intramuscular) of Streptozotocin at 4 mg/100 g body weight was given for diabetes induction. Treatment with aqueous or ethanol or methanol or hydro-ethanol (40:60) or hydro-methanol (40:60) extract of Aloe vera (L.) was continued for 28 days. Rats were euthanized and sacrificed on 29th day. Fasting blood glucose level, hexokinase activity, androgenic key enzyme activities, and markers of oxidative stress were assessed. Concentration of the sperm per milliliter of epididymal washed fluid, sperm motility, serum testosterone, plasma insulin levels, lipid, and metabolic toxicity sensors were also measured. Significant amelioration (p˂0.05) of the negatively deviated above-mentioned parameters and the disrupted histomorphology of testicles towards vehicle-treated control were noted after uninterrupted 28 days of treatment to diabetic rat with the mentioned extracts of Aloe vera (L.). Highest percentage of recovery in the adopted sensors was noted in the hydro-ethanol extract-treated diabetes group than others. Hydro-ethanol extract of the said plant part is potent among all other extracts for correcting such hypo-function of testicles in diabetes.

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Gliclazide alone or in combination with atorvastatin ameliorated reproductive damage in streptozotocin-induced type 2 diabetic male rats

Abstract: Graphical abstract

Cited by 10 publications

References 44 publications

Metabolic Syndrome and Reproduction

Metabolic Syndrome and Reproduction

Liraglutide ameliorates diabetic-induced testicular dysfunction in male rats: role of GLP-1/Kiss1/GnRH and TGF-β/Smad signaling pathways

Amelioration of Diabetes Associated Hypo-testicular Co-morbidities in Rat by <i>Aloe vera</i> (L.): Potent Extract Selection Study

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