Amelioration of Diabetes Associated Hypo-testicular Co-morbidities in Rat by <i>Aloe vera</i> (L.): Potent Extract Selection Study

Abstract

The present experiment was conducted to get the most effective extract of Aloe vera (L.) leaf gel for the correction of testicular hypo-function in diabetic rat. A single-time injection (intramuscular) of Streptozotocin at 4 mg/100 g body weight was given for diabetes induction. Treatment with aqueous or ethanol or methanol or hydro-ethanol (40:60) or hydro-methanol (40:60) extract of Aloe vera (L.) was continued for 28 days. Rats were euthanized and sacrificed on 29th day. Fasting blood glucose level, hexokinase activity, androgenic key enzyme activities, and markers of oxidative stress were assessed. Concentration of the sperm per milliliter of epididymal washed fluid, sperm motility, serum testosterone, plasma insulin levels, lipid, and metabolic toxicity sensors were also measured. Significant amelioration (p˂0.05) of the negatively deviated above-mentioned parameters and the disrupted histomorphology of testicles towards vehicle-treated control were noted after uninterrupted 28 days of treatment to diabetic rat with the mentioned extracts of Aloe vera (L.). Highest percentage of recovery in the adopted sensors was noted in the hydro-ethanol extract-treated diabetes group than others. Hydro-ethanol extract of the said plant part is potent among all other extracts for correcting such hypo-function of testicles in diabetes.