Glibenclamide mitigates cognitive impairment and hippocampal neuroinflammation in rats with type 2 diabetes and sporadic Alzheimer-like disease

Brain activities of streptozotocin-induced diabetic Wistar rats treated with gliclazide: Behavioural, biochemical and histomorphology studies

“…However, the latency with the novel object was less (p < 0.05) compared with the control group, which still indicates impairment of this brain function. The present results are at variance with reports of other sulphonylureas, glibenclamide and metformin, that mitigated cognitive impairments ( Herath et al, 2016 , Esmaeili et al, 2020 ).…”

A gliclazide complex based on palladium towards Alzheimer's disease: promising protective activity against Aβ-induced toxicity in C. elegans

“…The sulfonylurea family modulate ATP-sensitive potassium channels, which are involved in Ab-induced pathology. 19 In this context, glibenclamide treatment has been shown to reduce affective disorders, 20 memory impairment and neuroinflammation 21 as well as Ab deposition 22 in different rodent models of AD.…”

Swimming exercise decreases depression‐like behaviour and inflammatory cytokines in a mouse model of type 2 diabetes

“…The animal model of type 2 diabetes was produced by the Salari Institute of Cognitive and Behavioral Disorders (SICBD) as previously described (Esmaeili et al, 2020). Animals were randomly divided into two groups and were fed with a normal diet (ND) or a high-fat diet (HFD; 58% fat, 25% protein and 17% carbohydrate) for 2 weeks (Srinivasan et al, 2005).…”