2014
DOI: 10.1371/journal.pgen.1004647
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GLD-4-Mediated Translational Activation Regulates the Size of the Proliferative Germ Cell Pool in the Adult C. elegans Germ Line

Abstract: To avoid organ dysfunction as a consequence of tissue diminution or tumorous growth, a tight balance between cell proliferation and differentiation is maintained in metazoans. However, cell-intrinsic gene expression mechanisms controlling adult tissue homeostasis remain poorly understood. By focusing on the adult Caenorhabditis elegans reproductive tissue, we show that translational activation of mRNAs is a fundamental mechanism to maintain tissue homeostasis. Our genetic experiments identified the Trf4/5-type… Show more

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Cited by 30 publications
(41 citation statements)
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References 62 publications
(155 reference statements)
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“…By following aging hermaphrodites, we found that GLD-4 maintains the normal size of the proliferative zone and prevents its progressive shrinkage. 17 The lab of Judith Kimble had recently provided convincing evidence that the proliferative zone contains 2 pools of cells with distinct properties; a distal pool of about 30-70 germline stem cells (GSCs) that primarily proliferate to selfrenew, and a proximal pool of transitamplifying cells with presumably limited proliferation potential that are primed for differentiation. 26,27 Interestingly, the extent of the proliferative zone that remains in gld-4 mutants is similar to the distal GSC pool.…”
Section: Gld-4 Promotes Proliferationmentioning
confidence: 99%
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“…By following aging hermaphrodites, we found that GLD-4 maintains the normal size of the proliferative zone and prevents its progressive shrinkage. 17 The lab of Judith Kimble had recently provided convincing evidence that the proliferative zone contains 2 pools of cells with distinct properties; a distal pool of about 30-70 germline stem cells (GSCs) that primarily proliferate to selfrenew, and a proximal pool of transitamplifying cells with presumably limited proliferation potential that are primed for differentiation. 26,27 Interestingly, the extent of the proliferative zone that remains in gld-4 mutants is similar to the distal GSC pool.…”
Section: Gld-4 Promotes Proliferationmentioning
confidence: 99%
“…26,27 Interestingly, the extent of the proliferative zone that remains in gld-4 mutants is similar to the distal GSC pool. 17 Hence, GLD-4 may function primarily in transit-amplifying cells to control their proliferative capacity. Alternatively, due to a global requirement of GLD-4 in maintaining the expression of broadly acting proliferative factors, both pools of cells may have shrunken in gld-4 mutants.…”
Section: Gld-4 Promotes Proliferationmentioning
confidence: 99%
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