GLC Determination of Indoprofen in Plasma

Determination of Indoprofen in Physiological Fluids by Reversed-Phase Liquid Chromatography

“…The plasma decay curve agrees closely with the data of an earlier report (8). Plasma and urinary excretion levels (free and total) of indoprofen were determined for a subject receiving a single oral dose.…”

“…GLC methods for the analysis of indoprofen in plasma and urine have been reported (6)(7)(8). While each method has analytical validity and sufficient sensitivity, they all require extraction of indoprofen from the biological fluid and derivatization to provide the necessary volatility for GLC analysis.…”

Derivative formation in the quantitative gas-chromatographic analysis of pharmaceuticals. Part I. A review

“…Suitable small-and large-scale preparations from N-methyl-N-nitroso-ptoluenesulphonamide have been described together with precautions that must be exercised when working with diazomethane.lOs As the preparation using this reagent can give an interfering impurity, the use of N-methyl-N-nitroso-NI-nitroguanidine may be preferred. 109 Care must be employed when handling the diazomethane, which can be both toxic and -.…”

A Gas Chromatographic Screening Procedure for the detection of Non‐steroidal Anti‐inflammatory Drugs in horse urine

“…The increasing number of nonsteroidal anti-inflammatory agents available has hitherto presented problems in screening procedures for doping control. Although several chromatographic screening procedures have been described for individual compounds (Adams and Cliffe, 1965;Nash, Bopp and Rubin, 1971 ;Ferry, Ferry, Moller and McQueen, 1974;Kaiser and Vangiessen, 1974;Bland, Blake and Ray, 1976;Smith and Humphrey, 1977) these procedures are not applicable to this class of drug as a whole, because the chemical structures of its members are too diverse. In the work described here, use has been made of the presence of the carboxylic acid group, which is common to all of the compounds studied.…”