GLC Determination of Chlorpheniramine in Human Plasma Using a Nitrogen Sensitive Thermionic Detector

O’Brien, James E.; Hinsvark, O. N.; Bryant, William F.; Amsel, Lewis P.; Leaders, Floyd E.

doi:10.1080/00032717708067852

Cited by 5 publications

(2 citation statements)

References 3 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…one or two antihistamines (Table ). Only four research teams (O'Brien et al , ; Giachetti et al , ; Hattori et al , ; Nishikawa et al , ) managed to determine simultaneously different antihistamines along with other drugs in biological samples using NPD or FID. MS detection by chemical ionization (CI) (Fouda et al ., ; Kageura et al , ; Seno et al , ) and electron impact‐selected ion monitoring (EI‐SIM) (Kintz et al , ; Thompson and Leffert, ; Seno et al , ; Tonn et al , ; Martens, ; Hasegawa et al , ; Pujadas et al , ) have also been used for the determination of antihistamines after GC separation.…”

Section: Chromatographic Techniquesmentioning

confidence: 99%

Bioanalysis of antihistamines for clinical or forensic purposes

Katselou

Papoutsis

Νικολάου

et al. 2016

Biomedical Chromatography

View full text Add to dashboard Cite

Antihistamines are a class of drugs that inhibit the action of histamine and are used to alleviate symptoms associated with allergic reactions, but some of them can cause side effects, the most unpleasant and dangerous of which are the sedative effects that may hinder important psychological functions and impair skilled performance. These side effects could decrease safety in certain common and critical tasks, such as driving or operating machinery, leading to accidents. Antihistamines can also cause intoxications, sometimes lethal, especially when co-administered with alcohol or other sedative drugs. Thus, the development of analytical methods for their determination in biological fluids is considered to be useful for the investigation of clinical and forensic cases. These methodologies could also be used for pharmacokinetic studies. Several liquid and a few gas chromatographic methods have been developed for the determination of antihistamines in biological matrices after proper pretreatment procedures. This article reviews the published analytical methodologies that were gathered through the search in PubMed database and the recent developments on isolation or determination of antihistamines in biological materials. Current trends and future perspectives on bioanalysis of antihistamines are also discussed. Copyright © 2016 John Wiley & Sons, Ltd.

show abstract

Section: Chromatographic Techniquesmentioning

confidence: 99%

Bioanalysis of antihistamines for clinical or forensic purposes

Katselou

Papoutsis

Νικολάου

et al. 2016

Biomedical Chromatography

View full text Add to dashboard Cite

show abstract

“…However, several methods have been published for chlorpheniramine. These methods include GLC-MS (1,2), GLC-electron-capture detection (3), GLC-nitrogen-sensitive detection (4,5 ) and highperformance liquid chromatography (HPLC) (6,7).…”

mentioning

confidence: 99%