Capillary GLC Assay for Carbinoxamine and Hydrocodone in Human Serum Using Nitrogen-Sensitive Detection

Hoffman, Daniël J.; Leveque, Mary Jo; Thomson, Thomas D.

doi:10.1002/jps.2600721126

Cited by 15 publications

(3 citation statements)

References 10 publications

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“…USP 24 also recommends HPLC for the determination of hydrocodone [11] and oxycodone [12] in bulk and dosage forms. Radioimmunoassay [13,14], GLC [15,16], and HPLC [17,18,19,20] methods have been described for the determination of 6-oxo-morphinans in biological samples. GC-MS methods have been developed for the identification of medicinal opiates and illicit drugs [21,22,23,24].…”

Section: Introductionmentioning

confidence: 99%

Determination of 6-oxo-morphinans, as the oximes, by difference circular dichroism spectroscopy

Szentesi

Gergely

Horváth

et al. 2002

Analytical and Bioanalytical Chemistry

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A negative Cotton effect is observed in the circular dichroism (CD) spectra of 6-oxo-morphinans in the wavelength range of n-pi* electron transitions. 6-oxo-Morphinans can be transformed into oxime derivatives with hydroxylamine and after oxime formation the CD spectra are significantly different. Oxime formation was monitored by CD and by HPLC. It was established that under the experimental conditions used oxime formation was complete within 90 min. The method suggested for the determination of 6-oxo-morphinans is based on the considerable differences between the ellipticities before and after the oxime formation. The ellipticity difference varies linearly with concentration in the range 2 x 10(-5)-5 x 10(-4) mol L(-1) for the three 6-oxo-morphinans examined (oxycodone, hydrocodone, and 14-hydroxycodeinone). For hydrocodone the dependence is also linear in a lower concentration range (5 x 10(-6)-10(-4) mol L(-1)). The new difference CD spectroscopic method can be applied to the selective determination of 6-oxo-morphinans in bulk and dosage forms.

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Section: Introductionmentioning

confidence: 99%

Determination of 6-oxo-morphinans, as the oximes, by difference circular dichroism spectroscopy

Szentesi

Gergely

Horváth

et al. 2002

Analytical and Bioanalytical Chemistry

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“…Several methods were found in the literature for the determination of CAR, PHL, and EPH either alone or in combination with other drugs. Various analytical methods were established for the analysis of CAR, such as spectrophotometry (2)(3)(4)(5), HPLC (6)(7)(8)(9), capillary electrophoresis (CE) (10), GC (11,12), and LC-MS (13). Concerning PHL, it was determined by HPLC (14)(15)(16)(17)(18)(19), CE (20), GC (21,22), and LC-MS (23).…”

mentioning

confidence: 99%

Novel Approach for the Simultaneous Determination of Carbinoxamine Maleate, Pholcodine, and Ephedrine Hydrochloride Without Interference from Coloring Matter in an Antitussive Preparation Using Smart Spectrophotometric Methods

Moustafa

Hegazy

Mohamed

et al. 2018

Journal of AOAC INTERNATIONAL

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The presence of coloring matters in syrups usually interferes with the spectrophotometric determination of active pharmaceutical ingredients. A novel approach was introduced to eliminate the interference of sunset yellow (coloring matter) in Cyrinol syrup. Smart, simple, accurate, and selective spectrophotometric methods were developed and validated for the simultaneous determination of a ternary mixture of carbinoxamine maleate, pholcodine, and ephedrine hydrochloride in syrup. Four of the applied methods used ratio spectra: successive derivative subtraction coupled with constant multiplication, successive derivative of ratio spectra, ratio subtraction coupled with ratio difference, and ratio spectra continuous wavelet transforms zero-crossing. In addition, a method that was based on the presence of an isosbestic point, the amplitude summation method, was also established. A major advantage of the proposed methods is the simultaneous determination of the mentioned drugs without prior separation steps. These methods were successfully applied for the determination of laboratory-prepared mixtures and a commercial pharmaceutical preparation without interference from additives, thus proving the selectivity of the methods. No significant difference regarding both accuracy and precision was observed upon statistical comparison of the results obtained by the proposed methods with each other and with those of official or reported ones.

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“…Taking into consideration diverse biodynamic activities such as analagesic 1 , antibacterial 2 , antidiabetic 3 , antifungal 4 , antialcer 5,6 , antihistaminic 7 , anthlminitic 8 , antiinflammatory 9 , antimicrobial 10 etc.The Mannich bases (4a-4l) have been synthesized by the condensation of 4-(2,3 ' -dichlorophenyl) piperazine hydrochloride, cyclohexanone with aromatic aldehyde in the presence of hydrochloric acid. All the products (4a-4l)were assigned with IR, 1 HNMR, Mass Spectra, TLC and Elemental analysis.…”

Section: Introductionmentioning

confidence: 99%

Synthesis, Antibacterial and Antifungal Activity of 2-{1’-Aryl-1’-[4’’-(2’’’, 3’’’-Dichlorophenyl) Piperazin-Yl]-Methyl}-Cyclohexanone Hydrochloride

Roshan¹

2018

IJRASET

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Capillary GLC Assay for Carbinoxamine and Hydrocodone in Human Serum Using Nitrogen-Sensitive Detection

Cited by 15 publications

References 10 publications

Determination of 6-oxo-morphinans, as the oximes, by difference circular dichroism spectroscopy

Determination of 6-oxo-morphinans, as the oximes, by difference circular dichroism spectroscopy

Novel Approach for the Simultaneous Determination of Carbinoxamine Maleate, Pholcodine, and Ephedrine Hydrochloride Without Interference from Coloring Matter in an Antitussive Preparation Using Smart Spectrophotometric Methods

Synthesis, Antibacterial and Antifungal Activity of 2-{1’-Aryl-1’-[4’’-(2’’’, 3’’’-Dichlorophenyl) Piperazin-Yl]-Methyl}-Cyclohexanone Hydrochloride

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