Glaucoma severity affects diffusion tensor imaging (DTI) parameters of the optic nerve and optic radiation

Sidek, Sabrilhakim; Ramli, Norlisah; Rahmat, Kartini; Abdulrahman, F.; Tan, Li Kuo

doi:10.1016/j.ejrad.2014.05.014

Cited by 43 publications

(38 citation statements)

References 23 publications

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“…In the evaluation of the central visual pathway based on DTI parameters and LGN size, the FA of the optic tract was identified as the most reliable and useful indicator for the clinical evaluation of glaucoma. This result is in line with the results of previous studies, indicating that FA may be more sensitive to glaucomatous changes and may be an indicator of glaucomatous severity (9,16). From a pathological viewpoint, these results imply that histological lesions of the optic tract in glaucoma may be more marked compared with LGN and optic radiation changes.…”

Section: Discussionsupporting

confidence: 92%

“…However, few studies have focused on the diagnostic value of changes in DTI parameters of the central visual pathway and in LGN size in POAG. In a DTI study, Sidek et al (16) demonstrated that the FA of the optic nerve had a high sensitivity and specificity in distinguishing mild glaucoma from severe glaucoma. However, to date, how LGN height and volume are associated with optic fiber changes has remained elusive.…”

Section: Discussionmentioning

confidence: 99%

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Diagnostic utility of central damage determination in glaucoma by magnetic resonance imaging: An observational study

Song

et al. 2018

Exp Ther Med

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The aim of the present study was to investigate the utility of diffusion tensor imaging (DTI) parameters of the central visual pathway and the size of the lateral geniculate nucleus (LGN) in the diagnosis of primary open-angle glaucoma (POAG). To test this, 24 POAG patients and 24 age-and gender-matched controls underwent 3.0 Tesla magnetic resonance imaging examinations, including DTI and LGN structural imaging. Receiver operating characteristic (ROC) curves were generated and Spearman's correlation coefficients were also determined. The results indicated that regarding the discrimination of POAG patients from healthy controls, the fractional anisotropy (FA) values of the optic tract, at a cutoff of ≤0.412, with an area under the ROC curve of 0.931, exhibited the highest sensitivity (79.2%) and specificity (89.6%). The FA values of the optic tract and the optic radiation were significantly correlated with LGN size, while the mean diffusivity values were not. In conclusion, the FA value of the optic tract may be a sensitive and reliable biomarker for glaucoma evaluation.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 99%

Diagnostic utility of central damage determination in glaucoma by magnetic resonance imaging: An observational study

Song

et al. 2018

Exp Ther Med

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“…First, it challenges the notion that the brain degeneration commonly observed in glaucoma is solely a consequence of propagated pre‐geniculate damage. Previous studies suggest that elevated IOP causes the loss and apoptosis of RGCs . Increased IOP would block the transport of neurotrophic factors (e.g.…”

Section: Discussionmentioning

confidence: 99%

Neurodegeneration beyond the primary visual pathways in a population with a high incidence of normal‐pressure glaucoma

Boucard

Hanekamp

Ćurčić‐Blake

et al. 2016

Ophthalmic Physiologic Optic

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Citation information: Boucard CC, Hanekamp S, C ´ urč ic´-ic´ic´-Blake B, Ida M, Yoshida M & Cornelissen FW. Neurodegeneration beyond the primary visual pathways in a population with a high incidence of normal-pressure glaucoma. Abstract Purpose: Glaucoma is the most common age-related neurodegenerative eye disease in western society. It is an insidious disease that, when untreated or detected too late, leads inevitably to blindness. An outstanding issue is whether glaucoma should be considered exclusively an eye disease or also a brain disease. To further examine it, we used Diffusion Tensor Imaging (DTI) to study white matter integrity in a Japanese glaucoma population. This population has a very high incidence of normal-pressure glaucoma, in which optic nerve damage occurs in the absence of the elevated eye pressure that characterises the more common form of glaucoma. Methods: We performed DTI in 30 participants with normal-pressure glaucoma and 21 age-matched healthy controls. We used voxel-wise tract-based spatial statistics to compare fractional anisotropy and mean diffusivity of the white matter of the brain between patients and control group. Whole-brain and region of interest-based analyses served to find associations between diffusion indices and clinical measures of glaucomatous damage. Results: Fractional Anisotropy was significantly lower in glaucoma patients in a cluster in the right occipital lobe (p < 0.05; family-wise error-corrected) comprising fibres of both the optic radiation and the forceps major. Additional analysis confirmed bilateral involvement of the optic radiations and forceps major and additionally revealed damage to the corpus callosum and parietal lobe (p < 0.09; family-wise error-corrected). The region of interest-based analysis revealed a positive association between Fractional Anisotropy of the optic radiation and optic nerve damage. Conclusions: In this specific population, glaucoma is associated with lower Fractional Anisotropy in the optic radiations, forceps major and corpus callosum. We interpret these reductions as evidence for white matter degeneration in these loci. In particular, the degeneration of the corpus callosum suggests the presence of neurodegeneration of the brain beyond what can be explained on the basis of propagated retinal and pre-geniculate damage. We discuss how this finding links to the emerging view that a brain component that is independent from the eye damage plays a role in the aetiology of glaucoma.

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“…There is a significant increase in mean diffusivity as well as a significant decrease in FA in patients with glaucoma (5,8,29). In a study on 60 glaucoma patients compared with 30 normal control subjects, Sidek et al (26) concluded that DTI-derived FA values of the optic nerve has a strong correlation with disease severity in glaucoma. Kaushik et al (16) further extended the relation between severity of glaucoma and visual pathways.…”

Section: Original Articlementioning

confidence: 96%

Decision Making for Patients With Concomitant Pituitary Macroadenoma and Ophthalmologic Comorbidity: A Clinical Controversy

2015

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Glaucoma severity affects diffusion tensor imaging (DTI) parameters of the optic nerve and optic radiation

Cited by 43 publications

References 23 publications

Diagnostic utility of central damage determination in glaucoma by magnetic resonance imaging: An observational study

Diagnostic utility of central damage determination in glaucoma by magnetic resonance imaging: An observational study

Neurodegeneration beyond the primary visual pathways in a population with a high incidence of normal‐pressure glaucoma

Decision Making for Patients With Concomitant Pituitary Macroadenoma and Ophthalmologic Comorbidity: A Clinical Controversy

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