Diagnostic utility of central damage determination in glaucoma by magnetic resonance imaging: An observational study

Ke, Manlin; Song, Yinwei; Mu, Ketao; Zhang, Hong; Chen, Zhiqi

doi:10.3892/etm.2018.7134

Cited by 14 publications

(20 citation statements)

References 25 publications

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“…In the study by Furlanetto [ 34 ] of 3T MRI of LGN, however, the only parameter that showed a significant difference between glaucoma and control groups was the LGN height. Furthermore, at 3T Li [ 12 ] examined 24 POAG patients and 24 controls and concluded that for distinguishing glaucomatous eyes from healthy eyes, measurements of the LGN volume exhibited a high sensitivity and specificity. They also observed that the use of LGN volume differentiates glaucomatous patients from healthy controls only at the advanced stage.…”

Section: Discussionmentioning

confidence: 99%

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Volume of Lateral Geniculate Nucleus in Patients with Glaucoma in 7Tesla MRI

Kosior‐Jarecka

Pankowska

Polit

et al. 2020

JCM

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The aim of the study was to assess the volume of the lateral geniculate nucleus (LGN) in patients with open-angle glaucoma in 7Tesla MRI and to evaluate its relation to RNFL thickness and VF indices. Material and methods. The studied group consisted of 20 open-angle glaucoma patients with bilaterally the same stage of glaucoma (11 with early glaucoma and nine with advanced glaucoma) and nine healthy volunteers from the Department of Diagnostics and Microsurgery of Glaucoma, Medical University of Lublin, Poland. Circumpapillary RNFL-thickness measurements were performed using OCT in all patients and visual fields were performed in the glaucoma group. A 7Tesla MRI was performed to assess the volume of both lateral geniculate bodies. Results. The LGN volume varied significantly between groups from 122.1 ± 14.4 mm3 (right LGN) and 101.6 ± 13.3 mm3 (left LGN) in the control group to 80.2 ± 17.7 mm3 (right LGN) and 71.8 ± 14.2 mm3 (left LGN) in the advanced glaucoma group (right LGN p = 0.003, left LGN p = 0.018). However, volume values from early glaucoma: right LGN = 120.2 ± 26.5 mm3 and left LGN = 103.2 ± 28.0 mm3 differed significantly only from values from the advanced group (right LGN p = 0.006, left LGN p = 0.012), but not from controls (right LGN p = 0.998, left LGN p = 0.986). There were no significant correlations between visual field indices (MD (mean deviation) and VFI (visual field index)) and LGN volumes in both glaucoma groups. Significant correlations between mean RNFL (retinal nerve fiber layers) thickness and corresponding and contralateral LGN were observed for the control group (corresponding LGN: p = 0.064; contralateral LGN: p = 0.031) and early glaucoma (corresponding LGN: p = 0.017; contralateral LGN: p = 0.008), but not advanced glaucoma (corresponding LGN: p = 0.496; contralateral LGN: p = 0.258). Conclusions. The LGN volume decreases in the course of glaucoma. These changes are correlated with RNFL thickness in early stages of glaucoma and are not correlated with visual field indices.

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Section: Discussionmentioning

confidence: 99%

“…Li [ 12 ] showed that fractional anisotropy–an index derived from diffusion tensor imaging–can be a measure of glaucoma damage in the optic tract. Lee et al [ 13 ] performed volumetric measures of the LGN in 7T MR with proton density weighting.…”

Section: Introductionmentioning

confidence: 99%

Volume of Lateral Geniculate Nucleus in Patients with Glaucoma in 7Tesla MRI

Kosior‐Jarecka

Pankowska

Polit

et al. 2020

JCM

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“…Diffusion tensor imaging is the development and deepening of diffusion-weighted imaging, the only non-invasive examination method that can effectively observe and track the bundles of white matter fibers in the brain ( Li et al, 2019 ). The function change can be revealed by the parameters of DTI, such as radial diffusivity (λ⊥), axial diffusivity (λ ‖), and fractional anisotropy (FA).…”

Section: The Phenomenon Of Demyelinationmentioning

confidence: 99%

Demyelination of the Optic Nerve: An Underlying Factor in Glaucoma?

Xue

Zhu

Zhe

et al. 2021

Front. Aging Neurosci.

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Neurodegenerative disorders are characterized by typical neuronal degeneration and axonal loss in the central nervous system (CNS). Demyelination occurs when myelin or oligodendrocytes experience damage. Pathological changes in demyelination contribute to neurodegenerative diseases and worsen clinical symptoms during disease progression. Glaucoma is a neurodegenerative disease characterized by progressive degeneration of retinal ganglion cells (RGCs) and the optic nerve. Since it is not yet well understood, we hypothesized that demyelination could play a significant role in glaucoma. Therefore, this study started with the morphological and functional manifestations of demyelination in the CNS. Then, we discussed the main mechanisms of demyelination in terms of oxidative stress, mitochondrial damage, and immuno-inflammatory responses. Finally, we summarized the existing research on the relationship between optic nerve demyelination and glaucoma, aiming to inspire effective treatment plans for glaucoma in the future.

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“…They are sensitive to high-frequency space and transmit red and green color information (Schiller and Malpeli, 1978 ; Hendry and Calkins, 1998 ; Masri et al, 2020 ). Several studies have shown that both the M and P layers of the LGN are damaged in monkey glaucoma models (Dandona et al, 1991 ; Chaturvedi et al, 1993 ; Vickers et al, 1997 ; Weber et al, 2000 ; Yucel et al, 2000 , 2001 ; Sasaoka et al, 2008 ; Ito et al, 2009 , 2011 ; Yan et al, 2017 ), and this conclusion has also been confirmed in human glaucoma patients (Gupta et al, 2006 , 2009 ; Dai et al, 2011 ; Hernowo et al, 2011 ; Shimazawa et al, 2012 ; Chen et al, 2013b ; Lee et al, 2014 ; Wang et al, 2015 , 2016 ; Zhang et al, 2016 ; Ersoz et al, 2017 ; Song et al, 2018 ; Xu et al, 2018 ; Li et al, 2019a ; Kosior-Jarecka et al, 2020 ). Weber et al used a laser-induced chronic glaucoma monkey model to explore changes in size, density, and number of LGN neurons during glaucoma.…”

Section: Transneuronal Degeneration In Glaucoma Brainmentioning

confidence: 68%

Transneuronal Degeneration in the Brain During Glaucoma

You

Rong

Zeng

et al. 2021

Front. Aging Neurosci.

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The death of retinal ganglion cells (RGCs) is a key factor in the pathophysiology of all types of glaucoma, but the mechanism of pathogenesis of glaucoma remains unclear. RGCs are a group of central nervous system (CNS) neurons whose soma are in the inner retina. The axons of RGCs form the optic nerve and converge at the optic chiasma; from there, they project to the visual cortex via the lateral geniculate nucleus (LGN). In recent years, there has been increasing interest in the dysfunction and death of CNS and retinal neurons caused by transneuronal degeneration of RGCs, and the view that glaucoma is a widespread neurodegenerative disease involving CNS damage appears more and more frequently in the literature. In this review, we summarize the current knowledge of LGN and visual cortex neuron damage in glaucoma and possible mechanisms behind the damage. This review presents an updated and expanded view of neuronal damage in glaucoma, and reveals new and potential targets for neuroprotection and treatment.

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Diagnostic utility of central damage determination in glaucoma by magnetic resonance imaging: An observational study

Cited by 14 publications

References 25 publications

Volume of Lateral Geniculate Nucleus in Patients with Glaucoma in 7Tesla MRI

Volume of Lateral Geniculate Nucleus in Patients with Glaucoma in 7Tesla MRI

Demyelination of the Optic Nerve: An Underlying Factor in Glaucoma?

Transneuronal Degeneration in the Brain During Glaucoma

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