Glaucoma Progression Detection: Agreement, Sensitivity, and Specificity of Expert Visual Field Evaluation, Event Analysis, and Trend Analysis

Antón, Alfonso; Pazos, Marta; Martín, Belén; Navero, J.; Ayala, Miriam Eleonora; Castany, Marta; Martínez, P. Hernández; Bardavio, J.

doi:10.5301/ejo.5000193

Cited by 26 publications

(14 citation statements)

References 26 publications

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“…11–13 Event and trend-based progression analyses showed similar sensitivity and specificity but moderate agreement. 14 However, VF tests are difficult for some patients and are known to have increased variability, especially in patients with advanced disease. 15 The between-visit reproducibility of VF mean deviation ranges from 0.6 to 1.2 dB (standard deviation) from early to advanced glaucoma, which translates to a coefficient of variation (CV) of approximately 13 to 28% when the dB (logarithmic) units are converted to linear sensitivity.…”

Section: Introductionmentioning

confidence: 99%

Comparison of Glaucoma Progression Detection by Optical Coherence Tomography and Visual Field

Zhang

Dastiridou

Francis

et al. 2017

American Journal of Ophthalmology

116

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Purpose To compare longitudinal glaucoma progression detection using optical coherence tomography (OCT) and visual field (VF). Design Validity assessment Method We analyzed subjects with more than 5 follow-up visits (every 6 months) in the multi-center Advanced Imaging for Glaucoma Study. Fourier-domain optical coherence tomography (OCT) was used to map the thickness of the peripapillary retinal nerve fiber layer (NFL) and ganglion cell complex (GCC). OCT-based progression detection was defined as a significant negative trend for either NFL or GCC. VF progression was reached if either the event or trend analysis reached significance. Result The analysis included 417 glaucoma suspect/pre-perimetric glaucoma (GS/PPG) eyes and 377 perimetric glaucoma (PG) eyes. In the GS/PPG group, progression was detect in 38.9% of eyes by OCT, significantly more (P<0.001) than the detection rate of 18.7% by VF. In severity-stratified analysis of PG eyes, OCT had significantly higher detection rate in early PG (49.7% vs. 32.0%, p=0.02), but not significantly different in moderate and advanced PG. The rate of NFL thinning declined dramatically in advanced PG, but GCC thinning rate remained relatively steady and allowed good progression detection even in advanced disease. The rate of false positive progression detection in permutated series was over 10% for VF trend analysis in both GS/PPG and PG group, while under 7% for both GCC and NFL. Conclusion OCT is a more sensitive than VF for the detection of progression in early glaucoma. While the value of NFL declines in advanced glaucoma, GCC appears to be a useful progression detector from early to advanced stages.

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Section: Introductionmentioning

confidence: 99%

Comparison of Glaucoma Progression Detection by Optical Coherence Tomography and Visual Field

Zhang

Dastiridou

Francis

et al. 2017

American Journal of Ophthalmology

116

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“…However other authors 1,14 have obtained higher rates of sensitivity for GPA II when the reference standard comprised experts using objective systems to detect progression such as those of Hodapp et al 15 or Boden et al 16 based on pattern deviation plot. Pattern deviation analysis may underestimate the number of cases with progression since it does not detect diffuse changes of glaucomatous progression [17][18][19] or changes in very advanced cases where thresholds are very low or out of range; 14 it may also detect progression in cases of perimetric fluctuation. The inability to detect atypical or initial diffuse glaucomatous progression 5 and changes in advanced glaucoma, coupled with the use of very strict criteria to detect progression explains why GPA II in our work presented low sensitivity when compared to a reference standard using subjective criteria of progression.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Visual Field Progression in Glaucoma: Quasar Regression Program and Event Analysis

Díaz-Alemán

González-Hernández

Perera-Sanz

et al. 2015

Current Eye Research

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“…We reviewed literature to see the reliability of our approach. Anton et al [33] studied progression assessed subjectively by glaucoma experts, and by GPA event analysis and GPA trend analysis. They reported high agreement between the GPA event analysis and expert subjective assessment, and moderate agreement with GPA trend analysis.…”

Section: Discussionmentioning

confidence: 99%

Comparison of event-based analysis of glaucoma progression assessed subjectively on visual fields and retinal nerve fibre layer attenuation measured by optical coherence tomography

et al. 2014

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The purpose is to study the ability of an event-based analysis of retinal nerve fibre layer (RNFL) attenuation measured by Stratus(®) optical coherence tomography (OCT) and to detect progression across the spectrum of glaucoma. Adult glaucoma suspects, ocular hypertensives and glaucoma patients who had undergone baseline RNFL thickness measurement on Stratus OCT and reliable automated visual field examination by Humphrey's visual field analyser prior to March 2007 and had 5-year follow-up data were recruited. Progression on OCT was defined by two criteria: decrease in average RNFL thickness from baseline by at least 10 and 20 µ. Visual field progression was defined by the modified Hodapp-Parrish-Anderson criteria. Absolute and percentage change in RNFL thickness from baseline was compared in progressors and non-progressors on visual fields. Concordance between structural and functional progression was analysed. 318 eyes of 162 patients were analysed. 35 eyes (11 %) progressed by visual fields, 8 (2.5 %) progressed using the 20 µ loss criterion, while 30 eyes (9.4 %) progressed using the 10 µ loss criterion. In glaucoma suspects, mean absolute RNFL attenuation was 8.6 µ (12.1 % of baseline) in those who progressed to glaucoma by visual fields. OCT was more useful to detect progression in early glaucoma, but performed poorly in advanced glaucoma. The 10 µ criterion appears to be closer to visual field progression. However, the ability to detect progression varies considerably between functional and structural tools depending upon the severity of the disease.

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Glaucoma Progression Detection: Agreement, Sensitivity, and Specificity of Expert Visual Field Evaluation, Event Analysis, and Trend Analysis

Cited by 26 publications

References 26 publications

Comparison of Glaucoma Progression Detection by Optical Coherence Tomography and Visual Field

Comparison of Glaucoma Progression Detection by Optical Coherence Tomography and Visual Field

Evaluation of Visual Field Progression in Glaucoma: Quasar Regression Program and Event Analysis

Comparison of event-based analysis of glaucoma progression assessed subjectively on visual fields and retinal nerve fibre layer attenuation measured by optical coherence tomography

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