Evaluation of Visual Field Progression in Glaucoma: Quasar Regression Program and Event Analysis

Díaz-Alemán, Valentín Tinguaro; González-Hernández, Marta; Perera-Sanz, Daniel; Armas-Dominguez, K

doi:10.3109/02713683.2015.1020169

Cited by 2 publications

(2 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It seems clear that glaucoma is multifactorial and that individual susceptibility plays a role in the development and progression of the disease. Although high IOP is still the only known modifiable risk factor [13], the translaminar pressure gradient, i.e., the difference between IOP and cerebrospinal fluid pressure, has been identified as a risk factor for glaucomatous damage. This gradient is important in ocular diseases where the pressure on one or both sides of the lamina cribrosa is abnormally high or abnormally low [14].…”

Section: Discussionmentioning

confidence: 99%

Age, Maximum Cup Depth, Central Corneal Thickness, Disc Area and Mean Defect in Patients with Open Angle Glaucoma and Ocular Hypertension

Díaz-Alemán¹,

González-Hernández²,

Ángel-Pereira³

et al. 2016

OJOph

View full text Add to dashboard Cite

Purpose: The main objective was to analyze the relationship between maximum cup depth (MCD), mean defect (MD), central corneal thickness (CCT), age and disc area, in patients with ocular hypertension (OHT) and primary open angle glaucoma (POAG). Methods: Cross-sectional study of patients diagnosed with OHT and POAG. Visual fields were obtained using an Octopus 300 analyzer, TOP strategy. MCD and disc area were obtained using a Heidelberg Retina Tomograph. Results: The study sample comprised 234 eyes of 143 patients, 91 women and 52 men, mean age 63.55 years (SD 10.49). Mean values were: MCD 0.52 mm (SD 0.27), MD 2.78 dB (SD 5.02), CCT 543.5 µm (SD 36.63), IOP 16. 73 mmHg (SD 2.93), and disc area 2.01 mm 2 (SD 0.39). A significant correlation was observed between MCD and age in patients under 60 years, between MCD and disc area, and between MD and disc area. Conclusions: Our study showed a correlation between MCD and age which was significant in patients under 60 years of age, between MCD and disc area and between MD and disc area, suggesting that the larger the disc area, the greater the MCD and the MD in patients with OHT and POAG.

show abstract

Section: Discussionmentioning

confidence: 99%

Age, Maximum Cup Depth, Central Corneal Thickness, Disc Area and Mean Defect in Patients with Open Angle Glaucoma and Ocular Hypertension

Díaz-Alemán¹,

González-Hernández²,

Ángel-Pereira³

et al. 2016

OJOph

View full text Add to dashboard Cite

show abstract

“…A linear function always has a straight-line graph, whereas an exponential function yields a curved graph. Previous studies on glaucoma progression have suggested that glaucoma damage progresses linearly, but the evidence supporting this is limited 10 – 12 .…”

Section: Introductionmentioning

confidence: 99%

Estimating functions for visual field progression in newly diagnosed exfoliation glaucoma patients in Sweden

Ayala

2023

Sci Rep

View full text Add to dashboard Cite

This study aimed to determine whether glaucoma progression was linear or not in newly diagnosed exfoliation glaucoma patients. A total of 96 patients with newly diagnosed exfoliation glaucoma were included. These patients were required to undergo at least seven visual field tests within 3 years (± 1 month), and all were treated at the time of inclusion. The study was a non-randomized, prospective cohort study. The outcome of the study was visual field progression. Progression was assessed based on mean deviation (MD), visual field index (VFI), and “Guided Progression Analysis”. The MD and VFI values were plotted against time, and distribution and curve fit were calculated. The results showed that the general rate of progression of the cohort was − 3.84 (± 2.61) dB for the MD values and 9.66 (± 6.25)% for the VFI values over 3 years. The best-fitted curve for MD and VFI values in the 36 months period was significant for both linear and exponential curves (p ≤ 0.001; p ≤ 0.001). However, in the MD group, the F and the R2 values were higher for exponential than for linear function (linear: F = 42.60, R2 = 0.059; exponential: F = 53.26, R2 = 0.073). The opposite results were found among VFI values. The F and the R2 values were slightly better for linear than for exponential (linear: F = 37.22, R2 = 0.052; exponential: F = 35.55, R2 = 0.050). In conclusion, the study found that visual field progression between diagnosis and 18 months seemed to be exponential. However, after 18 months, the IOP reduction effects probably ameliorated progression, making the curve linear.

show abstract

Evaluation of Visual Field Progression in Glaucoma: Quasar Regression Program and Event Analysis

Abstract: The combination of MD and PSD regression analysis in the Quasar program showed better agreement with the experts and higher sensitivity than GPA II.

Cited by 2 publications

References 19 publications

Age, Maximum Cup Depth, Central Corneal Thickness, Disc Area and Mean Defect in Patients with Open Angle Glaucoma and Ocular Hypertension

Age, Maximum Cup Depth, Central Corneal Thickness, Disc Area and Mean Defect in Patients with Open Angle Glaucoma and Ocular Hypertension

Estimating functions for visual field progression in newly diagnosed exfoliation glaucoma patients in Sweden

Contact Info

Product

Resources

About