Glass-Ceramic-Mediated, Magnetic-Field-Induced Localized Hyperthermia: Response of a Murine Mammary Carcinoma

Luderer, Albert A.; Borrelli, Nicholas F.; Panzarino, Joseph N.; Mansfield, Gerald R.; Hess, Donna M.; Brown, Jacklyn L.; Barnett, E. Harvey; Hahn, Eric

doi:10.2307/3575874

Cited by 103 publications

(36 citation statements)

References 15 publications

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“…Finally, mice bearing breast carcinoma and implanted with a glass-ceramic were exposed to an alternating magnetic field (500 Oe=50mT and 10 kHz) and the authors observed a significant tumor growth delay without determining the local temperature achieved [231]. The available data indicate not only the feasibility, but also the potential of hyperthermic implants to treat bone tumors, despite too frequent lacunar characterization of the heating parameters.…”

Section: Thermotherapy Through Intraosseous Implantsmentioning

confidence: 98%

In situ forming implants for local chemotherapy and hyperthermia of bone tumors

Mohamed

Borchard

Jordan

2012

Journal of Drug Delivery Science and Technology

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Hyperthermia, an established adjuvant in cancer treatment, potentiates the effects of anticancer drugs and synergetic combination can be obtained improving the therapeutic outcome. Bone metastases may benefit from this combination when treated through in situ forming implants. Once loaded with magnetizable (nano-) particles and antineoplastic agents, these implants allow for the local application of magnetically-induced hyperthermia and the release of an anticancer drug. The implant can be heated applying an external magnetic field, sensitizing the surrounding tumoral tissues, while releasing the chemotherapeutic agent.Moreover, bone implants provide mechanical support to the weakened bone and consequently relieve pain.This review gives an overview of the current knowledge as well as the rationale of combining locally both magnetic hyperthermia and chemotherapy using in situ forming implants in the field of bone metastases treatment. KeywordsInduced hyperthermia, chemotherapy, drug delivery systems, in situ forming implants, iron oxide nanoparticles, bone metastases, cementoplasty, vertebroplasty 3

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Section: Thermotherapy Through Intraosseous Implantsmentioning

confidence: 98%

In situ forming implants for local chemotherapy and hyperthermia of bone tumors

Mohamed

Borchard

Jordan

2012

Journal of Drug Delivery Science and Technology

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“…In the 1980s, Luderer et al 8 reported that the ferrimagnetic glass-ceramics containing lithium ferrite and hematite crystallites in the system Al 2 O 3 -SiO 2 -P 2 O 5 can be useful as a thermoseed for hyperthermia in vivo. The heat generation of the materials is not, however, enough to kill the malignant carcinoma.…”

Section: Introductionmentioning

confidence: 99%

Research on annihilation of cancer cells by glass-ceramics for cancer treatment with external magnetic field. I. Preparation and cytotoxicity

Choi

Lee

et al. 2000

J. Biomed. Mater. Res.

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Ferrimagnetic glass-ceramics were prepared as a heating mediator for hyperthermia in cancer treatment. We prepared glasses in the system 40Fe2O3-30CaO-30SiO2 and precipitated ferrimagnetic crystallites through controlled two-step heat treatment. To improve the heating capability of ferrimagnetic crystallites, i.e., magnetite, generation of other crystalline phases should be prohibited. The addition of each 1% of P2O5 and B2O3 led to lowering the crystallization temperature of magnetite, which was useful to suppress the other crystalline formation. The maximum nucleating and crystal growth rates were 20.47 x 10(6)/mm2 x s at 690 degrees C and 8.125 nm/min(0.5) at 940 degrees C, respectively. After nucleation at 690 degrees C for 60 min prior to crystal growth at 940 degrees C for 2 h, samples exhibited the following properties: crystallite size of 90.5 nm, the maximum volumetric fraction of 31.1%, and saturation magnetization of 100 emu/cm2. The coercive forces were ranged between 382.0 and 388.2 Oe in all heat-treatment conditions. As a result of a preclinical evaluation of biocompatibility by agar diffusion test with L929 cells, both as-quenched and heat-treated glasses could be biocompatible.

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“…[5][6][7] The concept of inducing intracellular hyperthermia was proposed by Luderer et al since 1983. 8 The magnetite particles were capable of producing localized hyperthermia by hysteresis heating upon exposure to an alternating magnetic field. 9 In these studies, it has been reported that elevated temperatures could be with a selective effect on cancer cells.…”

Section: Introductionmentioning

confidence: 99%

The development of magnetic degradable DP‐Bioglass for hyperthermia cancer therapy

Wang

et al. 2007

J Biomedical Materials Res

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In this study, a novel magnetic degradable material was developed by adding Fe ions into DP-Bioglass (Na(2)O-CaO-P(2)O(5)-SiO(2)) as thermoseed for hyperthermia cancer therapy under an alternating magnetic field. We have investigated the properties of developed magnetic DP-Bioglass including morphology, chemical composition, and magnetism. The degradability was conducted by measuring the released concentrations of Na, Ca, Si, P, and Fe ions. The biocompatibility was analyzed by biological assays, and the functional hyperthermia effect to cancer cells was evaluated by in vitro cell culture test. In the results, the morphology of synthesized magnetic DP-Bioglass was revealed in sphere and rod shape with particle size around 50-100 nm. From the hysteresis loop analysis, it showed that the group of Fe/Bioglass = 0.2 possessed the maximum magnetization property. When cultured with fibroblasts, the magnetic DP-Bioglass had no significant influence on cell viability and mediated low cytotoxicity. The thermal-induced property demonstrated that after exposure to an alternating magnetic field, the cell number of human Caucasian lung carcinoma cells (A549) was significantly decreased when temperature was increasing to 45 degrees C. In brief, successfully incorporated with Fe ions by sol-gel method, this magnetic degradable DP-Bioglass possessed the potential and properties of hyperthermia effect to lung carcinoma cells.

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Glass-Ceramic-Mediated, Magnetic-Field-Induced Localized Hyperthermia: Response of a Murine Mammary Carcinoma

Cited by 103 publications

References 15 publications

In situ forming implants for local chemotherapy and hyperthermia of bone tumors

In situ forming implants for local chemotherapy and hyperthermia of bone tumors

Research on annihilation of cancer cells by glass-ceramics for cancer treatment with external magnetic field. I. Preparation and cytotoxicity

The development of magnetic degradable DP‐Bioglass for hyperthermia cancer therapy

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